Riassunto
La messa a punto di un metodo radioimmunologico per la determinazione dell'insulina ha permesso di rivedere tutta la patogenesi del diabete. Questa metodica inoltre fornisce dei preziosi ragguagli sull'evoluzione ed il trattamento dei casi di diabete.
Resume
Le développement d'une méthode radioimmunologique de détermination de l'insuline a permis de revoir toute la pathogénèse du diabète. Cette méthode apporte également des renseignements précieux sur l'évolution et le traitement des cas de diabète.
Resumen
El perfeccionamiento de un método radioinmunológico para la determinación de la insulina ha permitido reexaminar toda la patogénesis de la diabetes. Este método proporciona, además, valiosos datos sobre la evolución y el tratamiento de los casos de diabetes.
Zusammenfassung
Die Ueberarbeitung einer radioimmunologischen Methode fuer die Bestimmung des Insulins erlaubte die neue Durchsicht der gesamten Pathogenese des Diabetes. Diese Methode liefert ferner wertvolle Hinweise betr. die Entwicklung und Behandlung der Diabetesfaelle.
Summary
The setting-up of a radio-immunologic method for insulin assay enables us to put under discussion all the diabetes pathogenesis. This method supplies precious news about the course and the treatment of diabetes.
Bibliografia
Antoniades H. N., Beigelman P. M., Tranquada R. B., Gundersen K.: Studies on the State of Insulin in Blood: «Free» Insulin and Insulin Complexes in Human Sera and their in vitro Biological Properties - Endocrinology69 46, 1961.
Bermond P.: Connaissance de l'insulinémie et déductions thérapeutiques - Ann. Méd. de Reims3 107, 1966.
Felber J.-P., Moody A. J., Vannotti A.: Acides gras et diabète - Helv. med. Acta32 323, 1965.
Felber J.-P., Vannotti A.: Effet du taux des acides gras libres (NEFA) plasmatiques sur la glycémie et l'insulinémie - Helv. physiol. Acta22 13, 1964.
Felber J.-P., Vannotti A.: Effects of Fat Infusion on Glucose Tolerance and Insulin Plasma Levels - Med. exp. (Basel)10 153, 1966.
Felber J.-P., Zaragoza N., Grassi L., Moody A. J., Vannotti A.: Utilisation diminuée du glucose et accumulation de graisse chez l'obèse diabétique - Schweiz. med. Wschr. (in corso di stampa).
Floyd J. C. Jr.,Fajans S. S., Conn J. W., Knopf R. F., Rull J.: Stimulation of Insulin Secretion by Amino Acids - J. clin. Invest.45 1487, 1966.
Hales C. N., Randle P. J.: Immunoassay of Insulin with Insulin-Antibody Precipitate -Biochem. J.88 137, 1963.
Hugget A. St. G., Nixon D. A.: Enzymatic Determination of Blood Glucose- Biochem. J.66 12, 1956.
Karam J. H., Grodsky G. M., Forsham P. H.: Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay - Diabetes12 197, 1963.
Moody A. J., Felber J.-P.: A Diaphragm Bioassay for the Measurement of Total «Insulin-Like Activity» and of «Antigenic Insulin» in Serum - Experientia20 105, 1964.
Pfeiffer E. F., Ditschuneit H., Ziegler R.: Untersuchungen zur Pathogenese des menschlichen Altersdiabetes: Die Dynamik der Insulin-Sekretion des Stoffwechselgesunden und des Altersdiabetikers - Siebentes Symposium d. Dtsch. Ges. f. Endokr., Homburg (Saar) 1961. Springer, 1961, pag. 206.
Randle P. J., Garland P. B., Hales C. N., Newsholme E. A.: The Glucose Fatty Acid Cycle. Its Role in Insulin Sensitivity and the Metabolic Disturbances of Diabetes Mellitus -Lancet1 785, 1963.
Renold A. E., Martin D. B., Dagenais Y. M., Steinke J., Nickerson R. J., Sheps M. C.: Measurement of Small Quantities of Insulin-Like Activity Using Rat Adipose Tissue - J. clin. Invest.39 1487, 1960.
Samols E., Marri G., Marks V.: Promotion of Insulin Secretion by Glucagon - Lancet2 415, 1965.
Schalch D. S., Kipnis D. M.: Abnormalities in Carbohydrate Tolerance Associated with Elevated Plasma Nonesterified Fatty Acids - J. clin. Invest.44 2010, 1965.
Seltzer H. S., Harris V. L.: Exhaustion of Insulinogenic Reserve in Maturity-Onset Diabetic Patients during Prolonged and Continuous Hyperglycemic Stress - Diabetes13 6, 1964.
Unger R. H., Ketterer H., Eisentraut A., Dupé J.: Effect of Secretin on Insulin Secretion -Lancet2 24, 1966.
Vallance-Owen J.: Synalbumin Insulin Antagonism and Diabetes - Ciba Found. Coll. Endocr.15 217, 1964.
Williamson J. R., Krebs H. A.: Acetoacetate as fuel of Respiration in the Perfused Rat Heart - Biochem. J.80 540, 1961.
Yalow R. S., Berson S. A.: Plasma Insulin Concentrations in Nondiabetic and Early Diabetic Subjects - Diabetes9 254, 1960.
Yalow R. S., Berson S. A.: Immunoassay of Endogenous Plasma Insulin in Man - J. clin. Invest.39 1157, 1960.
Zaragoza N., Felber J.-P.: (in corso di stampa).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Felber, JP., Moody, AJ., Zaragoza, N. et al. Importance de la mesure radioimmunologique de l'insuline dans l'étude de la pathogénèse du diabète. Acta diabet. lat 4, 45–56 (1967). https://doi.org/10.1007/BF01543814
Issue Date:
DOI: https://doi.org/10.1007/BF01543814