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Gene for glutathione S-transferase-1 (GST1) is on human chromosome 11

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Somatic Cell Genetics

Abstract

The glutathione S-transferases (GST) are a group of related enzymes that can detoxify potentially carcinogenic electrophiles by conjugating them with reduced glutathione (GSH). The chromosomal location of one of the enzyme forms, GST1,reported recently to be polymorphic, was determined utilizing man-mouse somatic cell hybrids segregating human chromosomes. The expression of GST1by hybrid clones was compared with that of 34 enzyme markers representing 23 chromosomes, and karyotypes of selected cell hybrids were analyzed. The evidence indicated that GST1is assigned to chromosome 11 in humans. Utilizing an X/11 translocation segregating in hybrids, GST1was localized to the p13→ qter region of chromosome 11.

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Authors and Affiliations

  1. Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, 14263, Buffalo, New York

    David L. Silberstein & Thomas B. Shows

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  1. David L. Silberstein
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  2. Thomas B. Shows
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Silberstein, D.L., Shows, T.B. Gene for glutathione S-transferase-1 (GST1) is on human chromosome 11. Somat Cell Mol Genet 8, 667–675 (1982). https://doi.org/10.1007/BF01542859

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  • DOI: https://doi.org/10.1007/BF01542859

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