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Ovarian localization by embryonal teratocarcinoma cells derived from female germ gells

Somatic Cell Genetics volume 5, pages 763–780 (1979)Cite this article

Abstract

Embryonal carcinoma cells derived from several different spontaneous ovarian teratocarcinomas of strain LT mice form tumors that are located exclusively, in many cases, in the ovaries of female mice. Embryonal cells previously unselected for site specificity localize in the ovaries regardless of route of entry of the cells, and produce very few tumors in males following intraperitoneal injections. The ovary tumors have been verified as originating from the injected cells by chromosomal and drug resistance markers, as well as by general in vitro growth characteristics. Cell-cell adhesion studies suggest specificity at the level of tumor cell-ovary organ cell interaction.

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Literature cited

  1. Kleinsmith, L. J., and Pierce, G. B., Jr. (1964).Cancer Res. 24:1544–1552.

    Google Scholar 

  2. Kahan, B., and Ephrussi, B. (1970).J. Natl. Cancer Inst. 44:1015–1036.

    Google Scholar 

  3. Rosenthal, M. D., Wishnow, R. M., and Sato, G. H. (1970).J. Natl. Cancer Inst. 44:1001–1014.

    Google Scholar 

  4. Martin, G. R. (1978). InDevelopment in Mammals, Vol. 3, (ed.) Johnson, M. H. (North-Holland, Amsterdam), pp. 225–266.

    Google Scholar 

  5. Jacob, F. (1978).Proc. R. Soc. Land. B. 201:249–270.

    Google Scholar 

  6. Gachelin, G. (1978).Biochim. Biophys. Acta 516:27–60.

    Google Scholar 

  7. Solter, D., and Knowles, B. B. (1978).Proc. Natl. Acad. Sci. U.S.A. 75:5565–5569.

    Google Scholar 

  8. Kemler, R. (1978). InIII International Conference on Differentiation: Differentiation and Neaplasia, Minneapolis, Minnesota, Aug. 25–Sept. 1.

  9. Goodfellow, P., Levinson, J. R., Williams, V. E., and McDevitt, H. O. (1979).Proc. Natl. Acad. Sci. U.S.A. 76:377–380.

    Google Scholar 

  10. Stern, P. L., Willison, K. R., Lennox, E., Galfré, G., Milstein, C., Secher, D., and Ziegler, A. (1978).Cell 14:775–783.

    Google Scholar 

  11. Willison, K. R., and Stern, P. L. (1978).Cell 14:785–793.

    Google Scholar 

  12. Bechtol, K. B., Brown, S., and Kennett, R. H. (1979).Proc. Natl. Acad. Sci. U.S.A. 76:363–367.

    Google Scholar 

  13. Adamson, E. D., and Ayers, S. E. (1979).Cell 16: 953–965.

    Google Scholar 

  14. Wartiovaara, J., Leivo, I., Virtanen, I., Vaheri, A., and Graham, C. F. (1978).Nature 272:355–356.

    Google Scholar 

  15. Zetter, B. R., and Martin, G. R. (1978).Proc. Natl. Acad. Sci. U.S.A. 75:2324–2328.

    Google Scholar 

  16. Wolfe, J., Mautner, V., Hogan, B., and Tilly, R. (1979).Exp. Cell Res. 118:63–71.

    Google Scholar 

  17. Paulin, D., Nicolas, J. F., Yaniv, M., Jacob, F., Weber, K., and Osborn, M. (1978).Dev. Biol. 66:488–499.

    Google Scholar 

  18. Stevens, L. C., and Varnum, D. S. (1974).Dev. Biol. 37:369–380.

    Google Scholar 

  19. Eppig, J. J., Kozak, L. P., Eicher, E. M., and Stevens, L. C. (1977).Nature 269:517–518.

    Google Scholar 

  20. Mintz, B., and Illmensee, K. (1975).Proc. Natl. Acad. Sci. U.S.A. 72:3585–3589.

    Google Scholar 

  21. Illmensee, K. (1978). InGenetic Mosaics and Chimeras in Mammals, (ed.) Russell, L. B. (Plenum Press, New York), pp. 3–25.

    Google Scholar 

  22. Fidler, I. J. (1975).Cancer Res. 35:218–224.

    Google Scholar 

  23. DeMars, R., and Held, K. (1972).Humangenetik 16:87–110.

    Google Scholar 

  24. Artzt, K., Dubois, P., Bennett, D., Condamine, H., Babinet, C., and Jacob, F. (1973).Proc. Natl. Acad. Sci. U.S.A. 70:2988–2992.

    Google Scholar 

  25. Lehman, J. M., Speers, W. C., Swartzendruber, D. E., and Pierce, G. B. (1974).J. Cell. Physiol. 84:13–28.

    Google Scholar 

  26. Martin, G. R., and Evans, M. J. (1975). InRoche Symposium on Teratomas and Differentiation, (eds.) Solter, D., and Sherman, M. (Academic Press, New York), pp. 169–187.

    Google Scholar 

  27. Kahan, B., Held, K. R., and DeMars, R. (1974).Genetics 78:1143–1156.

    Google Scholar 

  28. Walther, B. T., Öhman, R., and Roseman, S. (1973).Proc. Natl. Acad. Sci. U.S.A. 70:1569–1573.

    Google Scholar 

  29. Youniss, S. T. (1976). BA thesis, University of Wisconsin, Madison.

    Google Scholar 

  30. Nicholson, G. L., and Winkelhake, J. L. (1975).Nature 255:230–232.

    Google Scholar 

  31. Winkelhake, J. L., and Nicholson, G. L. (1976)J. Natl. Cancer Inst. 56:285–291.

    Google Scholar 

  32. Auerbach, R. (1977). InCell and Tissue Interactions, (eds.) Lash, J. W., and Burger, M. M. (Raven Press, New York), pp. 47–55.

    Google Scholar 

  33. Conklin, J., and Abell, M. R. (1967).Cancer 20:2105–2117.

    Google Scholar 

  34. Peters, H. (1970)Phil. Trans. R. Soc. Land. B. 259:91–101.

    Google Scholar 

  35. Ciccarese, S., and Ohno, S. (1978).Cell 13:643–650.

    Google Scholar 

  36. Scheid, M., Boyse, E. A., Carswell, E. A., and Old, L. J. (1972).J. Exp. Med. 135:938–955.

    Google Scholar 

  37. Ohno, S. (1977).Immunol. Rev. 33:59–69.

    Google Scholar 

  38. Wachtel, S. S., and Hall, J. L. (1979).Cell 17:327–329.

    Google Scholar 

  39. Hoover, R. L., Briggs, R. T., and Karnovsky, M. J. (1978).Cell 14:423–428.

    Google Scholar 

  40. Oshima, R. (1978).Differentiation 11:149–155.

    Google Scholar 

  41. Kahan, B. (1978). InGenetic Mosaics and Chimeras in Mammals, (ed.) Russell, L. B. (Plenum Press, New York), pp. 297–328.

    Google Scholar 

  42. Ohno, S. (1964). InProc. 2nd. Int. Conf. Congenital Malformations Natl. Found., pp. 36–40.

  43. Stevens, L. C. (1970).Dev. Biol. 21:364–382.

    Google Scholar 

  44. Nicolas, J. F., Avner, P., Gaillard, J., Guénet, J. L., Jakob, H., and Jacob, F. (1976).Cancer Res. 36:4224–4231.

    Google Scholar 

  45. Gooding, L. R., and Edidin, M. (1974).J. Exp. Med. 140:61–78.

    Google Scholar 

  46. Heath, J. K. (1978).Cell 15:299–306.

    Google Scholar 

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Affiliations

  1. Zoology Department, University of Wisconsin, 53706, Madison, Wisconsin

    Brenda Kahan

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  1. Brenda Kahan
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This paper is dedicated to the memory of Boris Ephrussi, whose warm personal concern and wise tutelage during my graduate studies engendered a deep affection for him and for the areas of mammalian somatic genetics and embryology he pioneered.

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Kahan, B. Ovarian localization by embryonal teratocarcinoma cells derived from female germ gells. Somat Cell Mol Genet 5, 763–780 (1979). https://doi.org/10.1007/BF01542640

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  • DOI: https://doi.org/10.1007/BF01542640

Keywords

  • Drug Resistance
  • Intraperitoneal Injection
  • Female Mouse
  • Ovary Tumor
  • Growth Characteristic