Abstract
Sexual activity was evaluated in 51 women with hirsutism associated with increased levels of circulating androgens before and while on combined treatment with the antiandrogen cyproterone acetate (CA) and ethinyl estradiol (EE2) and compared to a reference group of 52 subjects. The percentage of unbound testosterone (T) was higher (p < 0.001), the coital frequency lower (p < 0.05), and the masturbation frequency higher (p< 0.04) in hirsute women. Mean frequency of total activity (coitus plus masturbation) was similar in the two groups. Treatment with combination of CA and EE2 resulted in a decline of unbound T (p< 0.001). There was no change of total sexual activity, but coital frequency increased (p < 0.05) and masturbation frequency declined (p < 0.04). It is concluded that raised levels of circulating androgens, as judged by free T concentration, are not of crucial importance in the expression of sexual behavior in hirsute women.
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Anderson, D. C., Lasley, B. L., Fisher, R. A., Shepherd, J. H., Newman, L., and Hendrickx, A. G. (1976). Transplacental gradients of sex hormone binding globulin in human and simian pregnancy.Clin. Endocrinol. 5: 657–669.
Appelt, H., and Strauss, B. (1984). Effects of antiandrogen treatment on the sexuality of women with hyperandrogenism.Psychother. Psychosom. 42: 177–181.
Cittadini, E. and Barreca, P. (1977). Use of anti-androgens in gynecology. In: Matini, L., and Motta, M., (eds.),Androgens and Anti-Androgens Raven Press, New York, pp. 152–159.
Crown, S. R., and Crisp, A. H. (1970). A short clinical diagnostic self-rating scale for psychoneurotic patients.Br. J. Psychiat. 112: 917–923.
Davidson, J. M. (1983). Androgens, natural and therapeutic in Women's sexuality. In Burrows, G. D., Dennerstein, L., and Fraser, I. S. (eds.),Obstetrics, Gynecology and Psychiatry, Proc. Cong. Austr. Soc. Psychosom. Obst. Gynaec, pp. 41–47.
Dow, M. G., Hart, D. M., and Forrest C. A. (1983). Hormonal treatments of sexual unresponsiveness in postmenopausal women.Br. J. Obstet. Gynaecol. 90: 361–366.
Ferriman, D., and Gallwey, J. D. (1961). Clinical assessment of body hair growth in women.J. Clin. Endocrinol. Metab. 21: 1441–1447.
Greenblatt, R. B. (1942). Androgenic therapy in women.J. Clin. Endrocrinol. 2: 665–666.
Kennedy, B. J. (1973). Effect of massive doses of sex hormones on libido.Med. Aspects Hum. Sex. 7: 67–78.
Laschet, U. (1973). Antiandrogen in the treatment of sex offenders: mode of action and therapeutic outcome. In Zubin, J., and Money, J. (eds.),Contemporary Sexual Behaviour: Clinical Issues in the 1970's Johns Hopkins University Press, Baltimore, pp. 311–319.
Matthews, A., Whitehead, A., and Kellett, J. (1983). Psychological and Hormonal factors in the treatment of female sexual dysfunction.Psychol. Med. 13: 83–92.
Money, J. (1967). Sex hormones and other variables in human eroticism. In Young, W. C, (ed.),Sex and Internal Secretions, Vol. 2, 3rd Ed, Williams and Wilkins, Baltimore, MD, pp. 1383–1400.
Raboch, J., Kobilková, J., Raboch, J. and Stárka, L. (1985). Sexual life of women with the Stein-Leventhal syndrome.Arch. Sex. Behav. 14: 263–270.
Sanders, D., and Bancroft, J. (1982). Hormones and the sexuality of women—the menstrual cycle.Clin. Endocrinol. Metab. 11: 639–657.
Shorr, E., Papanicolaou, G. N., and Stimmel, B. F. (1938). Neutralization of ovarian follicular hormone in women by simultaneous administration of male sex hormone.Proc. Soc. Exp. Biol. 38: 759–762.
Walker, P. A., Meyer, W. J., Emory, L. E., and Rubin, A. L. (1984). Antiandrogenic treatment of the paraphilias. In Stancer, H. C., Garfinkel, P. E., and Rakoff, V. M., (eds.),Guidelines for the Use of Psychotropic Drugs Medical Science Books, New York, pp. 427–443.
Waxenberg, S. E., Finkbeiner, J. A., Drellich, M. G., and Sutherland, A. M. (1960). The role of hormones in human behaviour.Psychosom. Med. 22: 435–442.
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Adamopoulos, D.A., Kampyli, S., Georgiacodis, F. et al. Effects of antiandrogen-estrogen treatment on sexual and endocrine parameters in hirsute women. Arch Sex Behav 17, 421–429 (1988). https://doi.org/10.1007/BF01542482
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DOI: https://doi.org/10.1007/BF01542482