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Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone

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Abstract

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters of sexual functions. Replacement of testosterone substitution therapy of agonadal men by dihydrotestosterone was likewise not associated with any change of sexual functioning. Administration of dihydrotestosterone to eugonadal men led to a transient increase of nocturnal sexual dreams and erections and irritability, waning after 3–4 weeks of dihydrotestosterone administration. It is concluded that aromatization of testosterone is not required and that dihydrotestosterone maintains sexual functions in the adult male with an established sex life.

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References

  • Davidson, J. M., Kwan, M., and Greenleaf, W. J. (1982). Hormonal replacement and sexuality in men. InClinics in Endocrinology and Metabolism 11, 599–625.

    PubMed  Google Scholar 

  • Emment, Y., Collins, W. P., and Sommerville, I. F. (1972). Radio-immunoassay of oestrone and oestradiol in human plasma.Acta Endocrinol. (Copenhagen) 69: 567–576.

    Google Scholar 

  • Gooren, L. J. G., van der Veen, E. A., van Kessel, H., and Harmsen-Louman, E. (1984a). Estrogens in the feedback regulation of gonadotropin secretion in men: Effects of administration of estrogen to agonadal subjects and the anti-estrogen tamoxifen and the aromatase inhibitor Δ′-testolactone to eugonadal subjects.Andrologia 16: 568–577.

    PubMed  Google Scholar 

  • Gooren, L J. G., van der Veen E. A., van Kessel, H., Harmsen-Louman, W., and Wiegel, A. R. (1984b). Androgens in the feedback regulation of gonadotropin secretion in men: Effects of administration of dihydrotestosterone to eugonadal and agonadal subjects and of spironolactone to eugonadal subjects.Andrologia 16: 289–298.

    PubMed  Google Scholar 

  • Kurl, R. N., and Morris, I. D. (1978). Differential depletion of cytoplasmatic high affinity oestrogen receptors afterin vivo administration of the antioestrogens clomiphene, MER-25.Brit. J. Pharmacol. 62: 487–493.

    Google Scholar 

  • Luisi, M., and Franchi, R. (1980). Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients.J. Endocrinol. Invest. 3: 305–308.

    Google Scholar 

  • MacLusky, N. L., and Naftolin, F. (1981). Sexual differentiation of the central nervous system.Science 211: 1294–1303.

    PubMed  Google Scholar 

  • McNair, L., Douglas, M., and Lorr, M. (1964). An analysis of mood in neurotics.J. Abnorm. Psychol. 69: 620–627.

    PubMed  Google Scholar 

  • Nieschlag, E., Mauss, J., Coert, A., and Kicovic, P. M. (1975). Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate.Acta Endocrinol. 79: 366–370.

    PubMed  Google Scholar 

  • Pratt, J. J., and Woldring, M. G. (1976). Radioimmunoassay specificity and the “first-come, first served” effect.Clin. Chim. Acta 68: 87–94.

    PubMed  Google Scholar 

  • Pratt, J. J., Wiegman, T., Lappöhn, R., and Woldring, M. G. (1975). Estimation of plasma testosterone without extraction and chromatography.Clin. Chim. Acta 59: 337–345.

    PubMed  Google Scholar 

  • Puri, V., Puri, C. P., and Anand Kumar, T. C. (1981). Serum levels of dihydrotestosterone in male rhesus monkeys estimated by a non-chromatographic radio-immunoassay method.J. Steroid Biochem. 14: 877–884.

    PubMed  Google Scholar 

  • Sachs, B. D., and Garinello, L. D. (1980). Hypothetical spinal pacemaker regulating penile reflexes in rats: Evidence from transsection of spinal cord and dorsal penile nerves.J. Comp. Physiol. Psychol. 94: 530–535.

    PubMed  Google Scholar 

  • Segaloff, A., Weeth, J. B., Meyer, K. K., Rongone, E. L., and Cunningham, M. E. (1962). Hormonal therapy in cancer of the breast: Effect of oral administration of Δ′-testolactone on clinical course and hormonal excretion.Cancer 22: 663–666.

    Google Scholar 

  • Skakkebaek, N. E., Bancroft, J., Davidson, D. W., and Warner, P. (1981). Androgen replacement with oral testosterone undecanoate in hypogonadal men: A double-blind controlled study.Clin. Endocrinol. 14: 49–61.

    Google Scholar 

  • Whitehead, A., and Matthews, A. (1976) Attitude change during behavioural treatment of sexual inadequacy.Brit. J. Soc. Clin. Psychol. 16: 275–281.

    Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology, Hospital of the Vrije Universiteit, Amsterdam, The Netherlands

    L. J. G. Gooren M.D.

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  1. L. J. G. Gooren M.D.
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Gooren, L.J.G. Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone. Arch Sex Behav 14, 539–548 (1985). https://doi.org/10.1007/BF01541754

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