Skip to main content
Log in

Effects of testosterone replacement on sexual behavior in hypogonadal men

  • Published:
Archives of Sexual Behavior Aims and scope Submit manuscript

Abstract

Fifteen patients with hypogonadism due to testicular, pituitary, or hypothalamic failure were studied. After a pretreatment period without substitution, patients received intramuscular injections of testosterone enanthate, equivalent to 25, 50, 100, and 250 mg testosterone, or placebo. Each dose was given for 4 weeks, with injections given every 2 weeks. All patients with plasma testosterone values below 2 ng/ml during the pretreatment period reported impaired sexual function. They responded to testosterone injections (50, 100, and 250 mg) with improvement of sexual behavior, as rated by sexual desire and frequency of erections and ejaculations. In the range between 2.0 and 4.5 ng testosterone per ml, four patients reported high frequencies of erections and ejaculations that did not change after testosterone treatment. Four other patients with testosterone values in the same range reported impaired sexual behavior and were successfully treated with testosterone enanthate. These data indicate that male sexual behavior is testosterone dependent and that the individual limit of plasma testosterone below which sexual behavior is impaired lies between 2.0 and 4.5 ng/ml.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bremer, J. (1959).Asexualization. A Follow-Up Study of 244 Cases. Macmillan, New York.

    Google Scholar 

  • Cornu, F. (1973).Katamnesen bei kastrierten Sittlichkeitsdelinquenten aus forensisch-psychiatrischer Sicht S. Karger, Basel, pp. 103–113.

    Google Scholar 

  • Davidson, J. M., Camargo, C. A., and Smith, E. R. (1979). Effects of androgen on sexual behavior in hypogonadal men.J. Clin. Endocrinol. Metab. 48(6): 955–958.

    PubMed  Google Scholar 

  • Langelüddecke, A. (1963).Die Entmannung von Sittlichkeitsverbrechern. Walter de Gruyter, Berlin, pp. 82–85.

    Google Scholar 

  • Odell, W. D., Rossa, G. T., and Rayford, P. L. (1967). Radioimmunoassay for luteinizing hormone in human plasma or serum-physiological studies.J. Clin. Invest. 46: 248.

    PubMed  Google Scholar 

  • Pirke, K. M. (1973). A comparison of three methods of measuring testosterone in plasma: Competitive protein binding, radioimmunoassay without and radioimmunoassay including thin layer chromatography.Acta Endocrinol. (Kbh.) 74: 168–176.

    Google Scholar 

  • Pirke, K. M., and Doerr, P. (1973). Age-related changes and interrelationships between plasma testosterone, oestradiol and testosterone-binding globulin in normal adult males.Acta Endocrinol. 74: 792.

    PubMed  Google Scholar 

  • von Zerssen, B., with Köller, B. M. (1976). Klinische Selbstbeurteilungs-Skalen (KSb-S) aus dem Münchener psychiatrischen Informations-System (PSY-CHIS-München). Manual: Die Befindlichkeits-Skala, Beltz, Weinheim.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salmimies, P., Kockott, G., Pirke, K.M. et al. Effects of testosterone replacement on sexual behavior in hypogonadal men. Arch Sex Behav 11, 345–353 (1982). https://doi.org/10.1007/BF01541595

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01541595

Key words

Navigation