Skip to main content
SpringerLink
Log in

Gastric mucosal PGE2 levels in gastric nonulcer and ulcer patients with chronic renal failure or without renal diseases and in healthy subjects

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

PGE2-like immunoactivity in mucosal specimens from gastric corpus and antrum was measured in individuals with chronic uremia or without renal diseases in absence or presence of gastric ulcerations and in healthy subjects. Regardless the group of patients, compared to normal mucosa, a significant decrease in PGE2-like immunoactivity (50–70%) was found in mucosa from atrophic, but not from superficial gastritis. Whenever patients of the control group or patients with renal diseases suffered from ulcers, PGE2-like immunoactivity, compared to nonulcer subjects, revealed a decrease of about 60–70% in the nonulcerated mucosa. Compared to nonulcerated mucosa, the tissue of the ulcer rim in all patients with gastric ulcer showed a relative increase in PGE2-like immunoactivity, eg, PGE2-like immunoactivity was twice as high in tissue from the ulcer rim. The outpout of PGE2-like immunoactivity into the gastric juice of subjects without renal diseases was comparable to that found in patients with chronic uremia in both basal and pentagastrin-stimulated conditions. We therefore conclude that gastric mucosal formation is probably not influenced by chronic uremia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ketterer A, Ritz E: Funktionelle Störungen und klinische Komplikationen am Magen-Darm-Trakt bei terminaler Nieren-insuffizienz.In Klinische Nephrologie, Vol I. H. Losse, E. Renner (eds). Stuttgart, Thieme, 1982, pp 445–451

    Google Scholar 

  2. Peskar BM, Weiler H, Meyer CH: Inhibition of prostaglandin production in the gastrointestinal tract by antiinflammatory drugs. Adv Inflam Res 6:40–49, 1984

    Google Scholar 

  3. Konturek SJ, Pawlik W: Physiology and pharmacology of prostaglandins. Dig Dis Sci 31(suppl):65–195, 1986

    PubMed  Google Scholar 

  4. Orczyk GP, Behrman HR: Ovulation blockade by aspirin or indomethacin—in vivo evidence for a role of prostaglandin in gonotropin secretion. Prostaglandins 1:3, 1972

    PubMed  Google Scholar 

  5. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275, 1951

    PubMed  Google Scholar 

  6. Jaffe BM, Behrman HR: Methods of Hormone Radioimmunoassays, 2nd ed. New York, Academic Press, 1979

    Google Scholar 

  7. Wormsley KG, Mahoney MP, Kay G: Gastric response to subcutaneous injection of a gastrin-like pentapeptide. Gut 8:475, 1967

    PubMed  Google Scholar 

  8. Arakawa T, Satoh H, Fukuda T, Nakamura H, Kobayashi K: Endogenous prostaglandin E2 in gastric mucosa of patients with alcoholic cirrhosis and portal hypertension. Gastroenterology 93:135–140, 1987

    PubMed  Google Scholar 

  9. Weiler H, Moser U, Weiler Ch, Gerok W: Studies on the effect of aminopterin and methotrexate on the release of prostaglandin PGE2, PGD2 and PGI2 from small intestine in the ratin vivo. Cancer 3:206–212, 1990

    Google Scholar 

  10. Whitehead R: Mucosal Biopsy of the Gastrointestinal Tract, 2nd ed. Philadelphia, WB Saunders, 1979

    Google Scholar 

  11. Scheffé H: A method for judging all contrasts in the analysis of variance. Biometrika 40:87–104, 1953

    Google Scholar 

  12. Kruskal WH, Wallis WA: Use of ranks in the one criterion variance analysis. J Am Statist Assoc 47:562–583, 1952

    Google Scholar 

  13. Wright JP, Young GO, Klaff LJ, Weers LA, Price SK, Morks JN: Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma. Gastroenterology 82:263–267, 1982

    PubMed  Google Scholar 

  14. Ligumsky M, Sharon P, Karmeli F, Rachmilewitz D: Prostaglandins and the pathogenesis of duodenal ulcer, no correlation with the gastric mucosal PGE2 content. Isr J Med Sci 15:171, 1979

    PubMed  Google Scholar 

  15. Weiler H, Weiler Ch, Gerok W: Gastric mucosal PGE2 levels in cirrhosis and portal hypertension. J Hepatology 11:58–64, 1990

    Google Scholar 

  16. Hawkey CJ: Synthesis of prostaglandin E2, thromboxane B2, and prostaglandin catabolism in gastritis and gastric ulcer. Gut 27:1484–1492, 1986

    PubMed  Google Scholar 

  17. Schlegel W, Wenk K, Dollinger HC, Raptis S: Concentrations of prostaglandin A-, E- and F-like substances in gastric mucosa of normal subjects and of patients with various diseases. Clin Sci Mol Med 52:255–258, 1977

    PubMed  Google Scholar 

  18. Andriulli A, Malfi B, Recchia S, Ponti V, Triolo G, Sogolini G: Patients with chronic renal failure are not a risk of developing chronic peptic ulcers. Clin Nephrol 23:245–248, 1985

    PubMed  Google Scholar 

  19. Poll M, Huber W, Werner J, Hoerr PW, Willig F: Endoskopische und histologische Veränderungen der Magenschleimhaut bei Patienten mit chronischer Niereninsuffizienz. Z Gastroenterol 19:33–38, 1981

    PubMed  Google Scholar 

  20. Morley J, Bray MA, Jones RW, Nugteren DM, Van Dorp DA: Prostaglandin and thromboxane production by human and guinea pig macrophages and leucocytes. Prostaglandins 17:730–736, 1979

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Freiburg, Hugstetter Str. 55, D-7800, Freiburg, FRG

    H. Weiler MD, Ch. Weiler & W. Gerok

Authors
  1. H. Weiler MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ch. Weiler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Gerok
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weiler, H., Weiler, C. & Gerok, W. Gastric mucosal PGE2 levels in gastric nonulcer and ulcer patients with chronic renal failure or without renal diseases and in healthy subjects. Digest Dis Sci 35, 1488–1493 (1990). https://doi.org/10.1007/BF01540566

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01540566

Key words

Search

Navigation