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Effects of zincl-carnosine on gastric mucosal and cell damage caused by ethanol in rats

Correlation with endogenous prostaglandin E2

Abstract

The effects of zincl-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosain vivo andin vivo. When given either intragastrically or intraperitoneally, zincl-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zincl-carnosine was not inhibited by indomethacin. Histological assessment showed that zincl-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl-prostaglandin E2. Zincl-carnosine (10−6 or 10−5 M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosain vivo; this effect was not inhibited by indomethacin. The results suggested that zincl-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.

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Correspondence to Dr. Tetsuo Arakawa MD, PhD.

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Arakawa, T., Satoh, H., Nakamura, A. et al. Effects of zincl-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Digest Dis Sci 35, 559–566 (1990). https://doi.org/10.1007/BF01540402

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Key words

  • zinc
  • zincl-carnosine
  • gastric mucosa
  • prostaglandin
  • indomethacin
  • cytoprotection