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Metabolism of a polychlorinated biphenyl (Aroclor® 1254) mixture in the rat

Summary

Male rats were orally dosed with Aroclor 1254 and residues were found in all tissues analyzed, with the greatest concentration in the fat. The GLC-EC pattern of the residues was different from the standard mixture administered, indicating that all components were not metabolized at the same rate. Higher residues were found in the carbon tetrachloride-treated rats. Aroclor 1254 residues in the brain, spleen, blood, testes, heart, kidney and fat were reduced by 90, 84, 80, 79, 78, 76, 64 and 33% respectively in 20 days. Aroclor 1254 significantly increased the size of the liver and also the percent lipid in the liver. Aroclor 1254 was found to potentiate the toxicity of carbon tetrachloride in the rat.

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References

  1. 1.

    von Oettingen, W.F., Public Health Service Publication No. 414, 306 (1955).

    Google Scholar 

  2. 2.

    Meigs, J.W., Albom, J.J., and Kartin, B.L., J. Am. Med. Assoc.154, 1417 (1954).

    Google Scholar 

  3. 3.

    Risebrough, R.W., Reiche, P., Peakall, D.B., Herman, S.G., and Kirven, M.N., Nature220, 1098 (1968).

    Google Scholar 

  4. 4.

    Jensen, New Scientist32, 612 (1966).

    Google Scholar 

  5. 5.

    Holmes, D.C., Simmons, J.H., Tatton, J.O'G., Nature216, 227 (1967).

    Google Scholar 

  6. 6.

    Holden A.V., and Marsden, K., Mature216, 1274 (1967).

    Google Scholar 

  7. 7.

    Koeman, J.H., Ten Noever De Brauw, M.C., and DeVos, R.H., Nature221, 1126 (1969).

    Google Scholar 

  8. 8.

    Jensen, S., Johnels, A.G., Olsson, M., and Otterlind, G., Nature224, 247 (1969).

    Google Scholar 

  9. 9.

    Duke, T.W., Lowe, J.I., and Wilson, A.J., Jr., Bulletin Environmental Contamination and Toxicology5, 171 (1970).

    Google Scholar 

  10. 10.

    Bagley, G. E., Reichel, W. L., and Cromartie, E., J. Assoc. Offic. Anal. Chem.53, 251 (1970).

    Google Scholar 

  11. 11.

    Westoo, G., Norén, K., and Andersson, M., Varfoda22, 9 (1970).

    Google Scholar 

  12. 12.

    Bligh, E.G., and Dyer, W.J., Can. J. Biochem. and Physiol.37, 911 (1959).

    Google Scholar 

  13. 13.

    McLean A.E.M. and McLean, E.K., Biochem. J.100, 564 (1966).

    Google Scholar 

  14. 14.

    Farber, T.M., Heider, A., Peters, E.L., Ritter, D.L., Disraely, M., and Van Loon, E.J., Ninth Annual Meeting, Society of Toxicology, Atlanta, Georgia, March 15–19 (1970).

  15. 15.

    Cawthorne, M.A., Bunyan, J., Sennitt, M.V., and Green, J., Br. J. Nutr.24, 357 (1970).

    Google Scholar 

  16. 16.

    Tanaka, K., Fujita, S., Komatsu, P., and Tamura, N., FukuokaIgaku-Zasshi60, 544 (1969).

    Google Scholar 

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Grant, D.L., Phillips, W.E.J. & Villeneuve, D.C. Metabolism of a polychlorinated biphenyl (Aroclor® 1254) mixture in the rat. Bull. Environ. Contam. Toxicol. 6, 102–112 (1971). https://doi.org/10.1007/BF01540090

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Keywords

  • Lipid
  • Toxicity
  • Waste Water
  • Water Management
  • Water Pollution