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Metabolism of a polychlorinated biphenyl (Aroclor® 1254) mixture in the rat


Male rats were orally dosed with Aroclor 1254 and residues were found in all tissues analyzed, with the greatest concentration in the fat. The GLC-EC pattern of the residues was different from the standard mixture administered, indicating that all components were not metabolized at the same rate. Higher residues were found in the carbon tetrachloride-treated rats. Aroclor 1254 residues in the brain, spleen, blood, testes, heart, kidney and fat were reduced by 90, 84, 80, 79, 78, 76, 64 and 33% respectively in 20 days. Aroclor 1254 significantly increased the size of the liver and also the percent lipid in the liver. Aroclor 1254 was found to potentiate the toxicity of carbon tetrachloride in the rat.

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Grant, D.L., Phillips, W.E.J. & Villeneuve, D.C. Metabolism of a polychlorinated biphenyl (Aroclor® 1254) mixture in the rat. Bull. Environ. Contam. Toxicol. 6, 102–112 (1971).

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  • Lipid
  • Toxicity
  • Waste Water
  • Water Management
  • Water Pollution