Abstract
Somatic cell hybrids produced between cercopithecoid monkey and Chinese hamster cells were used to assay susceptibility to SV40 viral infection in an attempt to define the primate factors that determine permissiveness to viral replication. These cell hybrids, which differed in their primate chromosome complement, were found to differ also in their ability to sustain viral replication. A correlation was found between an elevated SV40 viral replication and the presence of the chromosomes 11 in the rhesus monkey and 12 in the African green monkey which seem to be homologous to human 11. Preliminary studies also showed that the same chromosome seems to be responsible for the ability of the cell hybrids to rescue virus from rodent-transformed cells.
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Literature cited
Gerber, P. (1966).Virology 28:501.
Koprowski, H., and Knowles, B. (1974). InSomatic Cell Hybridisation, (ed.) Davidson, R., and de la Cruz, F. (Raven Press, New York), pp. 71–100.
Huebner, K., Shander, M., and Croce, C. (1977).Cell 11:25–33.
Westerveld, A., Visser, R.P.L.S., Meera Khan, P., and Bootsma, D. (1971).Nature (London), New Biol. 234:20–24.
Meera Khan, P. (1971).Arch. Biochem. Biophys. 145:470–483.
van Someren, H., Beyersbergen van Henegouwen, H., Los, W.R.T., Wurzer-Figurelli, E.M., Doppert, B.A., Vervloet, M., and Meera Khan, P. (1974).Hum. Genet. 25:189.
Bobrow, M., Madan, K., and Pearson, P.L. (1972).Nature (London), New Biol. 238:122–124.
Pearson, P.L., and van Egmond-Cowan, A.M.M. (1976). InNew Techniques in Biophysics and Cell Biology, Vol. 5, (ed.) Pain, R., and Smith, B. (Wiley & Sons, New York).
Hirt, B. (1967).J. Mol. Biol. 26:365.
Pagano, J. (1969). InFundamental Technique in Virology, (ed.) Habel, and Salzman. (Academic Press, New York).
Pope, J.H., and Rowe, W.P. (1964).J. Exp. Med. 120:121–127.
Hales, A. (1977).Somat. Cell Genet. 3(2):227–230.
Garver, J.J., Pearson, P.L., Estop, A., Dijksman, T., Wijnen, L., Westerveld, A., and Meera Khan, P. (1978).Cytogenet. Cell Genet. 22:564–569.
Pearson, P.L., Estop, A., Garver, J., Dijksman, T., Wijnen, L., and Meera Khan, P. (1978).Cytogenet. Cell Genet. 22:588–593.
Estop, A., Garver, J., Pearson, P.L., Dijksman, T., Wijnen, L., and Meera Khan, P. (1978).Cytogenet. Cell Genet. 22:558–563.
Estop, A., Garver, J., and Pearson, P.L. (1978).Genetica 49(2/3):131–138.
Croce, C., Huebner, K., and Koprowski, H. (1974).Proc. Natl. Acad. Sci. U.S.A. 71(10):4116–4119.
Sambrook, J., Westphal, H., Sprinivasan, P., and Dulbecco, R. (1968).Proc. Natl. Acad. Sci. U.S.A. 60:1288.
Black, P.H. (1966).Virology 28:760.
Righthand, V.F., and Bogshaw, J.C. (1978).Proceedings of the Fourth International Congress for Virology. The Hague, The Netherlands, p. 179.
Bootsma, D., and Ruddle, F. (1978).Cytogenet. Cell Genet. 22:74–91.
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Garver, J.J., Pearson, P.L., Abrahams, P.J. et al. Control of SV40 replication by a single chromosome in monkey-hamster cell hybrids. Somat Cell Mol Genet 6, 443–453 (1980). https://doi.org/10.1007/BF01539148
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DOI: https://doi.org/10.1007/BF01539148