Skip to main content
SpringerLink
Log in

A single-blind evaluation of thiothixene with outpatient schizophrenic children

  • Published:
Journal of autism and childhood schizophrenia Aims and scope Submit manuscript

Abstract

The results of a single-blind study assessing the effectiveness of thiothixene in a group of severely ill, outpatient schizophrenic children are presented with details pertaining to procedure and side effects. The subjects, 17 boys and one girl, ranged in age from 5 to 13 years. Thiothixene proved effective in all of the 18 schizophrenic children, as indicated by the psychiatrist's global impressions. Further evaluation of behavioral change, using a 23-item psychiatric rating scale, indicated significant improvement in motor activity, stereotyped behavior, coordination, sleeping, affect, exploratory behavior, concentration, eating habits, and range of communication. Despite relatively high dosages (10 to 24 mg per day) few side effects were noted during the course of the treatment period. It is suggested that thiothixene is a safe and effective antipsychotic agent for the treatment of schizophrenic children on an outpatient basis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Campbell, M., Fish, B., Shapiro, T., & Floyd, A., Jr. Thiothixene in young disturbed children.Archives of General Psychiatry, 1970,23, 70–72.

    PubMed  Google Scholar 

  • Creak, M. Schizophrenic syndrome in childhood: Progress report of a working party.Cerebral Palsy Bulletin, 1961,3, 501–504.

    Google Scholar 

  • Engelhardt, D. M., Polizos, P., & Margolis, R. A. The drug treatment of childhood psychosis. In W. L. Smith (Ed.),Drugs, development and cerebral function. Springfield, Ill.: Charles C Thomas, 1972.

    Google Scholar 

  • Silberstein, R. M., Mandell, W., Dalack, J. D., & Cooper, A. Avoiding institutionalization of psychotic children.Archives of General Psychiatry, 1968,19, 17–21.

    PubMed  Google Scholar 

  • Wolpert, A., Hagamen, M. B., & Merlis, S. A comparative study of thiothixene and trifluoperazine in childhood schizophrenia.Current Therapeutic Research, 1967,9, 482–485.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Psychopharmacology Research Unit, Department of Psychiatry, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, 11203, Brooklyn, New York

    Jonas Waizer, Polizoes Polizos, Stanley P. Hoffman,  David M. Engelhardt & Reuben A. Margolis

Authors
  1. Jonas Waizer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Polizoes Polizos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stanley P. Hoffman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David M. Engelhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Reuben A. Margolis
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by Grant MH 18180 from The National Institute of Mental Health, United States Public Health Service.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waizer, J., Polizos, P., Hoffman, S.P. et al. A single-blind evaluation of thiothixene with outpatient schizophrenic children. J Autism Dev Disord 2, 378–386 (1972). https://doi.org/10.1007/BF01538170

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01538170

Keywords

Search

Navigation