Autism in children with congenital rubella

  • Stella Chess


In the course of studying the behavioral characteristics of 243 preschool children with congenital rubella, we identified the syndrome of autism in 10 children and a partial syndrome of autism in an additional 8. These findings are discussed against the background of the behavioral investigations of rubella children. The methodology of our psychiatric study and the criteria for a diagnosis of autism are presented. The incidence of autism is considered with regard to the prevalence of other psychiatric disorders in this group and the physical status of the children. Two case histories of autistic rubella children are given and their behavioral characteristics are contrasted with nonautistic rubella children with matching sensory and other defects. The prevalence rate is compared with that found in two epidemiological studies and also with the rate indicated by other centers studying rubella children. Etiological implications of these findings are discussed. It is argued that these data support the concept of organic causation of the syndrome of autism.


Physical Status Epidemiological Study Psychiatric Disorder Prevalence Rate Preschool Child 
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  1. Bender, L. The life course of children with autism and mental retardation. In F. J. Menolascino (Ed.),Psychiatric approaches to mental retardation. New York: Basic Books, 1970.Google Scholar
  2. Bindon, D. M. Personality characteristics of rubella deaf children.American Annals of the Deaf, 1957,102, 264–270.Google Scholar
  3. Chess, S. Behavioral study of children with congenital rubella. Final Report to Children's Bureau, HEW. No. H-220 (C2), 1970.Google Scholar
  4. Chess, S., and Hassibi, M. Behavior deviations in mentally retarded children.Journal of the American Academy of Child Psychiatry, 1970,9, 282–297.PubMedGoogle Scholar
  5. Cooper, L. Z., & Krugman, S. Congenital rubella: Diagnosis and management.Journal of Pediatrics, 1966,37, 335.Google Scholar
  6. Cooper, L. Z., & Krugman, S. Clinical manifestations of postnatal and congenital rubella.Archives of Ophthalmology, 1967,77, 434–439.PubMedGoogle Scholar
  7. Creak, M. Schizophrenic syndrome in childhood: Progress report of a working party.Cerebral Palsy Bulletin, 1961,3, 501–504.Google Scholar
  8. Desmond, M. M., Wilson, G. S., Melnick, J. L., Singer, D. B., Zion, T. E., Rudolph, A. J., Pineda, R. G., & Ziai, M.H. Congenital rubella encephalitis.Journal of Pediatrics, 1967,71, 311–331.PubMedGoogle Scholar
  9. Desmond, M. M., Wilson, G. S., Verniaud, W. M., Melnick, J. L., & Rawls, W. E. The early growth and development of infants with congenital rubella.Advances in Teratology, 1970,4, 39–63.Google Scholar
  10. Freedman, D. A., Fox-Kolenda, B. J., & Brown, S. L. A multihandicapped rubella baby: The first 18 months.Journal of the American Academy of Child Psychiatry, 1970,9, 298–317.PubMedGoogle Scholar
  11. Gregg, N. M., Congenital cataract following German measles in the mother.Journal of the Ophthalmological Society of Australia, 1941,3, 35.Google Scholar
  12. Gubbay, S. S., Lobascher, M., & Kingerlee, P. A neurological appraisal of autistic children: Results of a Western Australian survey.Developmental Medicine and Child Neurology, 1970,12, 422–429.PubMedGoogle Scholar
  13. Hardy, J. B. Rubella and its aftermath.Children, 1970,16, 90–96.Google Scholar
  14. Hardy, J. B., Monif, G. R. G., & Sever, J. L. Studies in congenital rubella, Baltimore, 1964–1965. II. Clinical and virologie.Bulletin of The Johns Hopkins Hospital, 1966,118, 97–108.Google Scholar
  15. Kirman, B. H. Rubella as a cause of mental deficiency.Lancet, 1955,2, 1113–1115.Google Scholar
  16. Levine, E. S. Psychoeducational study of children born deaf following maternal rubella in pregnancy.American Journal of Diseases of Children, 1951,81, 627–635.PubMedGoogle Scholar
  17. Lotter, V. Services for a group of autistic children in Middlesex. In J. K. Wing (Ed.),Early childhood autism. Oxford: Pergamon Press, 1966.Google Scholar
  18. Lundstrom, R., & Ahnsjo, S. Mental development following maternal rubella: A follow-up study of children born in 1951–1952.Acta Paediatrica, 1962,51 (Suppl. 135), 153–159.Google Scholar
  19. Menser, M. A., Dods, L., & Harley, J. D. A twenty-five year follow-up of congenital rubella.Lancet, 1967,2, 1347.PubMedGoogle Scholar
  20. Rimland, B.Infantile autism. New York: Appleton-Century-Crofts, 1964.Google Scholar
  21. Rutter, M. Concepts of autism: A review of research.Journal of Child Psychology and Psychiatry, 1968,9, 1–25.PubMedGoogle Scholar
  22. Sheridan, M. D. Final report of a prospective study of children whose mothers had rubella in early pregnancy.British Medical Journal, 1964,2, 536–539.Google Scholar
  23. Swan, C., Tostevin, A. L., Moore, B., Mayo, H., & Black, G. H. B. Congenital defects in infants following infectious diseases during pregnancy.Medical Journal of Australia, 1943,21, 201–210.Google Scholar
  24. Treffert, D. A. Epidemiology of infantile autism.Archives of General Psychiatry, 1970,22, 431–438.PubMedGoogle Scholar
  25. Wing, L. The handicaps of autistic children—a comparative study.Journal of Child Psychology and Psychiatry, 1969,10, 1–40.PubMedGoogle Scholar

Copyright information

© Scripta Publishing Corporation 1971

Authors and Affiliations

  • Stella Chess
    • 1
  1. 1.New York University Medical CenterNew York

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