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Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered γ-aminobutyric acid (GABA)

Digestive Diseases and Sciences volume 34, pages 1211–1216 (1989)Cite this article

Abstract

Subcutaneous administration of a single dose of γ-aminobutyric acid (GABA, 10 mg/100 g) in conjunction with a pretreatment dose of aminooxyacetic acid (AOAA 2.5 mg/100 g subcutaneously) to prevent the degradation of GABA, significantly augmented the incidence and intensity of cysteamine HCl-induced duodenal ulceration in rats. This effect of GABA could be reduced by the GABA receptor antagonist, bicuculline (30 Μg/100 g subcutaneously). These results suggest peripheral GABA receptors can modulate cysteamine HCl-induced duodenal ulcer.

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Affiliations

  1. Digestive Diseases Research Group, Department of Physiology, University of Ottawa, 451 Smyth Road, K1H 8M5, Ottawa, Ontario, Canada

    Anthony Krantis PhD & Michelle Nicholson

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  1. Anthony Krantis PhD
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  2. Michelle Nicholson
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Krantis, A., Nicholson, M. Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered γ-aminobutyric acid (GABA). Digest Dis Sci 34, 1211–1216 (1989). https://doi.org/10.1007/BF01537269

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  • DOI: https://doi.org/10.1007/BF01537269

Key words

  • γ-aminobutyric acid
  • GABA
  • cysteamine HCl
  • duodenal ulcer
  • rat