Skip to main content
SpringerLink
Log in

Neurotensin changes the motor pattern in canine ileum from propulsive to segmenting

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Modulation of ileal propulsive motility by different doses of neurotensin has been determined in detail. In conscious dogs neurotensin (2.5, 5, and 10 pmol/kg/min) was intravenously infused during the propulsive motor pattern induced by an acaloric viscous meal. Motor patterns were recorded by seven closely spaced strain gauge transducers and analyzed by a computerized method. Luminal transit was measured fluoroscopically. Neurotensin changed the propulsive motor pattern induced by the acaloric meal into a segmenting pattern. Effects were dose-dependent and most striking at a dose of 10 pmol/kg/min. The transit of luminal contents decreased from 20 to 8 cm/min. This was achieved by the increase in the number of stationary contractions (31 vs 55%), the reduction in the length of contraction spread (3.8 vs 1.8 cm), and the decrease in the number of contractions (11.5 vs 9.2 contractions/min). The contraction force was enhanced from 67 to 107 mN. Because of the marked effects on ileal motor patterns, neurotensin might be involved in the regulation of digestive motility in the distal small intestine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Carraway R, Leemann SE: Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine and stomach. J Biol Chem 251:7045–7052, 1976

    PubMed  Google Scholar 

  2. Brown DR, Miller RJ: Neurotensin. Br Med Bull 38:239–245, 1982

    PubMed  Google Scholar 

  3. Buchan AMJ, Polak JM, Sullivan S, Bloom SR, Brown M, Pearse AGE. Neurotensin in the gut.In Gut Hormones. SR Bloom (ed). Edinburgh, Churchill Livingstone, 1978, pp 544–549

    Google Scholar 

  4. Al-Saffar A, Rosell S: Effects of neurotensin and neurotensin analogues on the migrating myoelectrical complexes in the small intestine of rats. Acta Physiol Scand 112:203–208, 1981

    PubMed  Google Scholar 

  5. Thor K, Rosell S, Rökaeus A, Kager L: (GLN4)-Neurotensin changes the motility pattern of the duodenum and proximal jejunum from a fasting-type to a fed-type. Gastroenterology 83:569–574, 1982

    PubMed  Google Scholar 

  6. Blackburn AM, Bloom SR, Long RG, Fletcher DR, Christofides ND, Fitzpatrick ML, Baron JH: Effect of neurotensin on gastric function in man. Lancet 1:987–989, 1980

    PubMed  Google Scholar 

  7. Hellström PM, Nylander G, Rosell S: Effects of neurotensin on the transit of gastrointestinal contents in the rat. Acta Physiol Scand 115:239–243, 1982

    PubMed  Google Scholar 

  8. Keinke O, Wulschke S, Ehrlein HJ: Neurotensin slow gastric emptying by a transient inhibition of gastric and a prolonged inhibition of duodenal motility. Digestion 34:281–288, 1986

    PubMed  Google Scholar 

  9. Mashford ML, Nilsson G, Rökaeus A, Rosell S: The effect of food ingestion on circulating neurotensin-like immunoreactivity (NTLI) in the human. Acta Physiol Scand 104: 244–246, 1978

    PubMed  Google Scholar 

  10. Rosell S, Rökaeus A: The effect of ingestion of amino acids, glucose and fat on circulating neurotensin-like immunoreactivity (NTLI) in man. Acta Physiol Scand 107:263–267, 1979

    PubMed  Google Scholar 

  11. Schemann M, Ehrlein HJ: Effects of neurohormonal agents on jejunal contraction spread and transit in the fed dog. Gastroenterology 90:1950–1955, 1986

    PubMed  Google Scholar 

  12. Thor PJ, Konturek JW, Sendur R, Konturek SJ: Comparison of neurotensin and fat on myoelectric activity pattern of the small bowel.In Gastrointestinal Motility. C Roman (ed). Lancaster, MTP Press, 1984, pp 343–348

    Google Scholar 

  13. Siegle ML, Ehrlein HJ: Interdigestive contractile patterns of the ileum in dogs. Am J Physiol 253:G452-G460, 1987

    PubMed  Google Scholar 

  14. Siegle ML, Ehrlein HJ: Digestive motor patterns and transit of luminal contents in the canine ileum. Am J Physiol 254: G552-G559, 1988

    PubMed  Google Scholar 

  15. Schemann M, Ehrlein HJ: Mechanical characteristics of phase II and phase III of the interdigestive migrating motor complex in dogs. Gastroenterology 91:117–123, 1986

    PubMed  Google Scholar 

  16. Schemann M, Ehrlein HJ: Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology 90:991–1000, 1986

    PubMed  Google Scholar 

  17. Wulschke S, Ehrlein HJ, Tsiamitas C: The control mechanisms of gastric emptying are not overridden by motor stimulants. Am J Physiol 251:G744-G751, 1986

    PubMed  Google Scholar 

  18. Schemann M, Siegle ML, Sahyoun H, Ehrlein HJ: Computer analysis of intestinal motility: Effects of cholecystokinin and neurotensin on jejunal contraction patterns. Z Gastroenterol 24:262–268, 1986

    PubMed  Google Scholar 

  19. Shaw C, Buchanan KD: Intact neurotensin (NT) in human plasma: Response to oral feeding. Regul Pept 7:145–153, 1983

    PubMed  Google Scholar 

  20. Wood JD: Intrinsic neural control of intestinal motility. Annu Rev Physiol 43:33–51, 1981

    PubMed  Google Scholar 

  21. Sakai Y, Daniel EE, Jury J, Fox JET: Neurotensin inhibition of canine intestinal motilityin vivo via α-adrenoceptors. Can J Physiol Pharmacol 62:403–411, 1984

    PubMed  Google Scholar 

  22. Williams JT, Katayama Y, North RA: The action of neurotensin on single myenteric neurones. Eur J Pharmacol 59:181–186, 1979

    PubMed  Google Scholar 

  23. Bueno L, Fioramonti J, Fargeas MJ, Primi MP: Neurotensin: A central neuromodulator of gastrointestinal motility in dogs. Am J Physiol 248:G15-G19, 1985

    PubMed  Google Scholar 

  24. Hellström PM: Vagotomy inhibits the effect of neurotensin of gastrointestinal transit in the rat. Acta Physiol Scand 128:47–55, 1986

    PubMed  Google Scholar 

  25. Fox JET, McLean J, Daniel EE, Sakai Y, Jury J: Neurotensin, evidence for multiple receptors for gastrointestinal motility action in dogs. Gastroenterology 82:1060, 1982

    Google Scholar 

  26. Huidobro-Toro JP, Zhu YX: Neurotensin receptors on the ileum of the guinea-pig: Evidence for the coexistence of inhibitory and excitatory receptors. Eur J Pharmacol 102:237–250, 1984

    PubMed  Google Scholar 

  27. Wood JD: Physiology of the enteric nervous system.In Physiology of the Gastrointestinal Tract, Vol 1, LR Johnson (ed). New York, Raven Press, 1987, pp 67

    Google Scholar 

  28. Siegle ML: Die interdigestive und digestive Motorik des Ileums beim Hund sowie die Wirkung verschiedener Hormone und Pharmaka auf die digestive Motorik. Dissertation, University of Hohenheim, 1988

Download references

Author information

Authors and Affiliations

  1. Institute of Zoophysiology, Division of Gastrointestinal Physiology, University of Hohenheim, Garbenstr. 30, D-7000, Stuttgart 70, FRG

    Marie-Luise Siegle &  Hans-Jörg Ehrlein

Authors
  1. Marie-Luise Siegle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hans-Jörg Ehrlein
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by the Deutsche Forschungsgemeinschaft Grant Eh 64/4-2.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siegle, ML., Ehrlein, HJ. Neurotensin changes the motor pattern in canine ileum from propulsive to segmenting. Digest Dis Sci 34, 1521–1527 (1989). https://doi.org/10.1007/BF01537104

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01537104

Key words

Search

Navigation