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Effect of low-dose exogenous secretin on pentagastrin- and meal-stimulated gastric acid secretion in humans

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Abstract

Intravenous infusion of secretin in a dose of 0.05 CU/kg/hr inhibited pentagastrin-stimulated (100 ng/kg/hr) acid secretion by 42% (P<0.05) abd meal-stimulated (10% peptone, pH 5.5) acid secretion by 33% (P<0.05) in 10 healthy subjects. Median serum gastrin concentration during peptone stimulation was reduced by 24% (P<0.05) during secretin infusion. Median plasma secretin concentrations were 6.0 and 5.2 pmol/liter, respectively. Since these secretin concentrations are of the same magnitude as those seen after duodenal acidification, it is concluded that secretin may participate in the physiological inhibition of gastric acid secretion.

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Authors and Affiliations

  1. Department of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark

    John Christiansen MD, Bjarne Hansen MD, Linda Hilsted MD & Ove B. Schaffalitzky De Muckadell MD

  2. Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

    John Christiansen MD, Bjarne Hansen MD, Linda Hilsted MD & Ove B. Schaffalitzky De Muckadell MD

  3. Department of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    John Christiansen MD, Bjarne Hansen MD, Linda Hilsted MD & Ove B. Schaffalitzky De Muckadell MD

Authors
  1. John Christiansen MD
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  2. Bjarne Hansen MD
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  3. Linda Hilsted MD
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  4. Ove B. Schaffalitzky De Muckadell MD
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Supported by grant 12-4525, Danish Medical Research Council

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Christiansen, J., Hansen, B., Hilsted, L. et al. Effect of low-dose exogenous secretin on pentagastrin- and meal-stimulated gastric acid secretion in humans. Digest Dis Sci 33, 1277–1281 (1988). https://doi.org/10.1007/BF01536680

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  • DOI: https://doi.org/10.1007/BF01536680

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