Abstract
Orocecal transit time was assessed with lactulose hydrogen breath test in 12 obese patients during intravenous infusion of placebo or naloxone 40 μg/kg/hr given in randomized order and in double-blind conditions. Transit time was also evaluated in 22 healthy controls. Orocecal transit was significantly (P<0.01) longer in the obese patients during placebo treatment (median 130, range 100–200 min) than in the healthy controls (median 75, range 40–170 min). Compared with placebo, transit time in the obese subjects was delayed (P<0.05) during naloxone treatment (median 150, range 100–230 min).
Similar content being viewed by others
References
Atkinson RL: Naloxone decreases food intake in obese humans. J Clin Endocrinol Metab 55:196–198, 1982
Wolkowitz OM, Doran AR, Cohen MR, Cohen RM, Wise TN, Pickar D: Effects of naloxone on food consumption in obesity. N Engl J Med 313:327, 1985
Atkinson RL, Berke LK, Drake CR, Bibbs ML, Williams FL, Kaiser DL: Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther 38:419–422, 1985
Givens JR, Wiedemann E, Andersen RN, Kitabchi AE: β-endorphin and β-lipotropin plasma levels in hirsute women: Correlation with body weight. J Clin Endocrinol Metab 50:975–976, 1980
Genazzani AR, Facchinetti F, Petraglia F, Pintor C, Corda R: Hyperendorphinemia in obese children and adolescents. J Clin Endocrinol Metab 62:36–40, 1986
Sninsky CA, Davis RH, Clench MH, Thomas KD, Mathias JR: Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A doubleblind study. Gastroenterology 90:68–73, 1986
Basilisco G, Bozzani A, Camboni G, Recchia M, Quatrini M, Conte D, Penagini R, Bianchi PA: Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test. Gut 26:700–703, 1985
Basilisco G, Camboni G, Bozzani A, Paravicini M, Bianchi PA: Oral naloxone antagonizes loperamide-induced delay of orocecal transit. Dig Dis Sci 32:829–832, 1987
Metz G, Gassul MA, Leeds AR, Blendis LM, Jenkis DJA: A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med 50:237–240, 1976
Zuccato E, Andreoletti M, Bozzani A, Marcucci F, Velio P, Bianchi PA: Respiratory excretion of hydrogen and methane in Italian subjects after ingestion of lactose and milk. Eur J Clin Invest 13:261–266, 1983
Lentner C (ed): Geigy Scientific Tables. Basle, Ciba-Geigy Limited, 1984, 3, p 326
Horowitz M, Collins PJ, Cook DJ, Harding PE, Shearman DJC: Abnormalities of gastric emptying in obese patients. Int J Obesity 7:415–421, 1983
Horowitz M, Collins PJ, Tuckwell V, Vernon-Roberts J, Shearman DJC: Fenfluramine delays gastric emptying of solid food. Br J Clin Pharmacol 19:849–851, 1985
Wright RA, Krinsky S, Fleeman C, Trujillo J, Teague E: Gastric emptying and obesity. Gastroenterology 84:747–751, 1983
Sasaki H, Nagulesparan M, Dubois A, Straus E, Samloff IM, Lawrence WH, Johnson GC, Sievers ML, Unger RH: Hypergastrinemia in obese noninsulin-dependent diabetes: A possible reflection of high prevalence of vagal dysfunction. J Clin Endocrinol Metab 56:744–750, 1983
Campbell IW, Heading C, Tothill P, Buist TAS, Ewing DJ, Clarke BF: Gastric emptying in diabetic autonomic neuropathy. Gut 18:462–467, 1977
Snape WJ Jr, Battle WM, Schwartz SS, Braunstein SN, Goldstein HA, Alavi A: Metoclopramide to treat gastroparesis due to diabetes mellitus. A double-blind, controlled trial. Ann Intern Med 96:444–446, 1982
Sasaki H, Nagulesparan M, Dubois A, Vasquez B, Johnson GC, Sievers ML, Unger RH: Hyperinsulinemia in obesity: Lack of relation to gastric emptying of glucose solution or to plasma somatostatin levels. Metabolism 32:701–705, 1983
Sasaki H, Nagulesparan M, Dubois A, Samloff IM, Straus E, Sievers ML, Unger RH: Gastric function and obesity: Gastric emptying, gastric acid secretion and plasma pepsinogen. Int J Obesity 8:183–190, 1984
Borody TJ, Quigley EMM, Phillips SF, Wienbeck M, Tucker RL, Haddad A, Zinsmeister AR: Effects of morphine and atropine on motility and transit in the human ileum. Gastroenterology 89:562–570, 1985
Feldman M, Walsh JH, Taylor IL: Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polipeptide concentrations in humans. Gastroenterology 79:294–298, 1980
Mittal RK, Frank EB, Lange RC, McCallum RW: Effects of morphine and naloxone on esophageal motility and gastric emptying in man. Dig Dis Sci 31:936–942, 1986
Camilleri M, Malagelada JR, Stanghellini V, Zinsmeister AR, Kao PC, Li CH: Dose related effects of synthetic human β-endorphin and naloxone on fed gastrointestinal motility. Am J Physiol 251:G147-G154, 1986
Kinsman RI, Read NW: Effect of naloxone on feedback regulation of small bowel transit by fat. Gastroenterology 87:335–337, 1984
Morley JE, Levine AS, Yamada T, Gebhard RL, Prigge WF, Shafer RB, Goetz FC, Silvis SE: Effect of exorphins on gatrointestinal function, hormonal release, and appetite. Gastroenterology 84:1517–1523, 1983
Schang JC, Devroede G: Beneficial effects of naloxone in a patient with intestinal pseudoobstruction. Am J Gastroenterol 80:407–411, 1985
Sharpe GR, Rees WDW, Adrian TE, Christofides ND, Bloom SR: Effect of naloxone on the antral motor response to solid food in man. Eur J Clin Invest 17:95–99, 1987
Champion MCC, Sullivan SN, Chamberlain M, Vezina W: Naloxone and morphine inhibit gastric emptying of solids. Can J Physiol Pharmacol 60:732–734, 1982
Sawynok J, Pinsky C, LaBella FS: Minireview on the specificity of naloxone as an opiate antagonist. Life Sci 25:1621–1632, 1979
Chapman RW, Sillery JK, Graham MM, Saunders DR: Absorption of starch by healthy ileostomates: Effect of transit time and of carbohydrate load. Am J Clin Nutr 41:1244–1248, 1985
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Basilisco, G., Camboni, G., Bozzani, A. et al. Orocecal transit delay in obese patients. Digest Dis Sci 34, 509–512 (1989). https://doi.org/10.1007/BF01536325
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01536325