We studied a bulk laxative containing methylcellulose in a group of normal subjects as well as in a group of chronically constipated individuals. The initial study in normal subjects was performed to show that the compound could increase fecal weight without significant side effects. Fifty healthy subjects were studied. Methylcellulose in daily doses of 4 g demonstrated a statistically significant increase in fecal frequency, fecal water, and fecal solids. In the second phase, we studied a group of 59 chronically constipated individuals treated with daily doses of the laxative containing either 1, 2, or 4 g of methylcellulose or 3.4 g psyllium. All of these doses resulted in statistically significant increases in stool frequency, water content, and fecal solids. There was no increase in individual stool weight from any of the laxative doses. Methylcellulose, in a daily dose as low as 1 g, is an effective laxative.
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Tainter ML: Methylcellulose as a colloid laxative. Proc Soc Exp Biol Med 54:77–79, 1943
Knight HF, Hodge HC, Samsei EP, DeLap RE, McCallister DD: Studies on single oral doses of a high gel point methylcellulose. J Am Pharm Assoc 41:427–429, 1953
Lehman AJ: The colloidal laxative. Modern Hosp 64:98–102, 1945
Laxative drug products for over-the-counter human use: Tentative final monograph. Fed Regist 50:2124-2158, 1985
Bass P, Dennis S: The laxative effects of lactulose in normal and constipated subjects. J Clin Gastroenterol 3:23–28, 1981
Marlett JA, Li BUK, Patrow CJ, Bass P: Comparative laxation of psyllium with and without senna in an ambulatory constipated population. Am J Gastroenterol 82:333–337, 1987
Johnson EJ, Marlett JA: A simple method to estimate neutral detergent fiber (NDF) content in typical daily menus. Am J Clin Nutr 44:127–134, 1986
Devroede G: Constipation: Mechanisms and management.In Gastrointestinal Disease, (eds). MH Sleisenger, JS Fordtran. Philadelphia, WB Saunders, 1983, pp 288–308
Berger FM; Ludwig BS; Wielich KH: The hydrophilic and acid binding properties of Alginates. Am J Dig Dis 20:39–42, 1953
Connell AM, Hilton C, Irvine G, Lennard-Jones JE, Misiewicz JJ: Variation in bowel habit in two population samples. Br Med J 2:1095–1099, 1965
Rentorff RC, Kashgarian M: Stool parameters of healthy adult males. Dis Colon Rectum 10:222–228, 1967
Shoulder P, Keighley MRB: Changes in colorectal function in severe idiopathic chronic constipation. Gastroenterology 90:414–420, 1986
Martelli H, Devroede G, Arhan P, Dugway C, Dornic C, Faverdin C: Some parameters of large bowel motility in normal man. Gastroenterology 75:612–618, 1978
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Hamilton, J.W., Wagner, J., Burdick, B.B. et al. Clinical evaluation of methylcellulose as a bulk laxative. Digest Dis Sci 33, 993–998 (1988). https://doi.org/10.1007/BF01535996
- methyl cellulose
- bulk laxative