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Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome

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Abstract

We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 μg/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1)pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.

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Authors and Affiliations

  1. Department of Medicine, Sections of Gastroenterology and Endocrinology, Tulane University Medical School, New Orleans, Louisiana

    Atilla Ertan MD, Ali Ozden MD, Ellen Golodner MD, Halil Degertekin MD & Akira Arimura MD

Authors
  1. Atilla Ertan MD
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  2. Ali Ozden MD
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  3. Ellen Golodner MD
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  4. Halil Degertekin MD
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  5. Akira Arimura MD
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This study was supported by the Gastroenterology Section Research Fund.

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Ertan, A., Ozden, A., Golodner, E. et al. Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome. Digest Dis Sci 33, 1596–1600 (1988). https://doi.org/10.1007/BF01535952

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  • DOI: https://doi.org/10.1007/BF01535952

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