Abstract
The cytoprotective effects of liquid sucralfate and a synthetic analog of prostaglandin E1 (PGE1) on acid-induced esophagitis in cats were studied. Esophagitis was induced in adult cats using a constant infusion of 0.1 N HCl at 1 ml/min for 20 min. Animals were infused for either one or three days. Mucosal lesions were evaluated by blinded investigators using both fiberoptic endoscopy and light microscopy. Histologic changes included basal cell hyperplasia, intraepithelial leukocytosis, and subepithelial leukocytosis. Liquid sucralfate given prior to acid infusion consistently prevented acid-induced lesions in both one- and three-day infusions, demonstrated by both endoscopy and quantitative histologic scoring. Indomethacin (200 μg/kg) given prior to sucralfate and acid did not affect sucralfate cytoprotection. Synthetic PGE1, given in doses of 5 μg/kg and 100 μg/kg, afforded no esophageal cytoprotection. These studies indicate that sucralfate is cytoprotective against acid-induced esophageal injury in cats, an effect that does not appear to be mediated by prostaglandin. In addition, synthetic PGE1 does not confer protection in this animal model.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761–767, 1979
Hollander D, Tarnawski A, Krause WJ, Gergely H: Protective effect of sucralfate against gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural and functional time sequence analysis. Gastroenterology 88(1):366–374, 1985
Hollander D: Efficacy of sucralfate for duodenal ulcers: A multicenter double blind trial. J Clin Gastroenterol 3(suppl 2):147–52, 1981
Sontag SJ, Mazure PA, Pontes JF, Beker SG, Dajani EZ: Misoprostil in the treatment of duodenal ulcer. A multicenter double-blind placebo controlled study. Dig Dis Sci 30(suppl):1595–1635, 1985
Schweitzer EJ, Barr BL, Johnson LF, Harmon JW: Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology 88(3):611–619, 1985
Orlando RC, Powell DW: Effect of sucralfate on esophageal epithelial resistance to acid in the rabbit. Gastroenterology 86(5):1201 1984 (abstract)
Eastwood GL, Beck BD, Castell DO, Brown FC, Fletcher JR: Beneficial effect of indomethacin on acid induced esophagitis in cats. Dig Dis Sci 26(7):601–608, 1981
Northway MG, Lipshitz HI, Osborne BM, Feldman MS, Mamel JJ, West JH, Szwarc IA: Radiation esophagitis in the opossum: Radioprotection with indomethacin. Gastroenterology 78(5):883–897, 1980
Hollander D, Tarnawski A, Gergely H, Zipser RD: Sucralfate protection of gastric mucosa against ethanol-induced injury: A prostaglandin-mediated process? Scand J Gastroenterology 101(suppl):97–102, 1984
Danesh BJZ, Duncan A, Mitchell G, Russell RI: Effect of sucralfate on the occurrence of mucosal damage induced in rats by acetylsalicylic acid (ASA) alone and when combined with taurodeoxycholic acid (TDCA) at different pH Values. Gastroenterology 88(5):1359, 1985 (abstract)
Okabe S, Takeuchi K, Kunimi H, Kanno M, Kawashima M: Effect of an antiulcer drug, sucralfate (a basic aluminum salt of sulfate disaccharide), on experimental gastric lesions and gastric secretion in rats. Dig Dis Sci 28:1304–1042, 1983
Borrero E, Margolis I, Bank S, Shulman N, Chardavoyne R: Antacid versus sucralfate in preventing acute gastrointestinal bleeding. A randomized trial on critically ill patients. Am J Surg 148(12):809–812, 1984
Caspary WF: The influence of glycocholic acid and sucralfate on transmural difference of the human stomach.In Duodenal Ulcer, Gastric Ulcer. Sucralfate: A New Therapeutic Concept. WF Caspary (ed). Sucralfate Symposium, 11th International Congress of Gastroenterology, Hamburg, June 1980. Munich, Urban and Schwarzenberg, 1981, pp 22–27
Tesler MA, Lim ES: Protection of gastric mucosa by sucralfate from aspirin-induced erosions. J Clin Gastroenterol 3(suppl 2):171–175, 1983
Caldwell JR: Sucralfate in the relief of gastrointestinal symptoms associated with nonsteroidal antiinflammatory drugs. South Med J 78(8):938–940, 1985
Tarnawski A, Blick ME, Stachura J, Hollander D, Fox LN: Comparison of sucralfate versus cimetidine in protection of the human gastric mucosa against alcohol injury. An endoscopic, histologic and ultrastructural assessment. Gastroenterology 88(5):1609, 1985 (abstract)
Geisinger KR, Wu WC: Endoscopy and biopsy.In Gastroesophageal Reflux Disease: Pathogenesis, Diagnosis and Therapy. DO Castell, WC Wu, DJ Ott, (eds). Mt. Kisco, New York, Futura Publishing, 1985, pp 154–165
Szabo S, Trier JS, Brown A, Schmoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228–236, 1985
Tarnawski A, Hollander D, Krause WJ, Zipser RD, Stachura J, Gergely H: Does sucralfate affect the normal gastric mucosa? Histologic, ultrastructural and functional assessment in the rat. Gastroenterology 90:893–905, 1986
Northway MG, Bennett A, Carroll M, Feldman MS, Mamel JJ, Lipshitz HI, Szwarc IA, Eastwood G: Comparative effects of antiinflammatory agents and radiotherapy on normal esophagus and tumors in animals. Gastroenterology 78(5):1229, 1980 (abstract)
Author information
Authors and Affiliations
Additional information
This study was supported by an educational grant from Marion Laboratories, Kansas City, Missouri.
Dr. Geisinger is an American Cancer Society Junior Faculty Clinical Scholar.
Rights and permissions
About this article
Cite this article
Katz, P.O., Geisinger, K.R., Hassan, M. et al. Acid-induced esophagitis in cats is prevented by sucralfate but not synthetic prostaglandin E. Digest Dis Sci 33, 217–224 (1988). https://doi.org/10.1007/BF01535736
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01535736