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Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats

Digestive Diseases and Sciences volume 33, pages 209–216 (1988)Cite this article

Abstract

Effects of atropine, cimetidine, and 16,16-dimethyl prostaglandin E2 (16,16-dmPGE2) on indomethacin-induced gastric lesions were investigated in rats by correlating their effects on gastric acid and HCO}-3 secretion and motility. Subcutaneously administered indomethacin (25 mg/kg) produced gastric mucosal lesions within 4 hr. In parallel studies, an equivalent dose of indomethacin inhibited gastric HCO}-3 secretion, and stimulated gastric motor activity measured as intraluminal pressure recordings, whereas acid secretion was unaffected. The lesions induced by indomethacin were significantly prevented by three agents: cimetidine (100 mg/kg), which reduced acid secretion; atropine (1 mg/kg), which reduced acid secretion and gastric motility; and 16,16-dmPGE2 (10 μg/kg), which reduced acid secretion and motility and increased gastric HCO− 3 secretion. If acid (150 mM HCl) was infused into the stomach (1.2 ml/hr) during indomethacin treatment, only the latter two agents significantly prevented the formation of gastric lesions in response to indomethacin. Since only the effect on gastric motility was common to these two agents (atropine and 16,16-dmPGE2), the increased gastric motility may be an important pathogenetic factor in indomethacin-induced gastric lesions. The presence of acid as well as a deficiency of endogenous PGs may be prerequisite for later extension of the lesions but cannot account for the induction of mucosal lesions in rats following administration of indomethacin.

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Affiliations

  1. Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, 607, Kyoto, Japan

    Shigeru Ueki MA, Koji Takeuchi PhD & Susumu Okabe PhD

Authors
  1. Shigeru Ueki MA
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  2. Koji Takeuchi PhD
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  3. Susumu Okabe PhD
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Ueki, S., Takeuchi, K. & Okabe, S. Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Digest Dis Sci 33, 209–216 (1988). https://doi.org/10.1007/BF01535735

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  • DOI: https://doi.org/10.1007/BF01535735

Key words

  • indomethacin
  • gastric lesion
  • acid
  • motility
  • rat