Abstract
We have proposed that gastric contractile activity mechanically induces ulcers in the nonsteroid antiinflammatory drug (NSAID)-treated rat. This study examines first the relationship between number (dose) of peristaltic contractions applied to the mucosa and the ulcer score. Second, it examines the relative roles of: altered gastric myoelectrical activity (MEA) resulting from indomethacin (Indo) pretreatment, insulin-induced gastric peristalsis, and a combination of the two in the generation of mucosal lesions. Third, it examines the effect of exogenous prostaglandin on the Indo-altered MEA and relates it to ulcerogenesis. Indo pretreatment increased gastric tone and MEA. In such animals, the dose of peristaltic contractions applied to the gastric wall was related to the ulcer score in a dose-dependent manner. Exogenous prostaglandin (PG) reversed the MEA effect of Indo and reduced ulceration. It is postulated that an altered smooth muscle state secondary to inhibition of prostaglandin synthesis (PG-S) renders the mucosa vulnerable to injury by peristaltic action.
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Mersereau WA, Hinchey EJ: Prevention of phenylbutazone ulcer in the rat by glucose: Role of a glycoprivic receptor system. Am J Physiol 242(Gastrointest Liver Physiol 5):G429-G432, 1982
Mersereau WA, Hinchey EJ: Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat. Surgery 90:516–522, 1981
Watanabe K: Some pharmacological factors involved in formation and prevention of stress ulcer in rats. Chem Pharm Bull 14:101–107, 1966
Dai S, Ogle CW: Effects of stress and of autonomic blockers on gastric mucosal microcirculation in rats. Eur J Pharmacol 30:86–92, 1975
Mersereau WA, Hinchey EJ: The role of hypothermia induced gastric hypercontractility in the genesis of the restraint ulcer. Can J Surg 24:622–625, 1981
Mersereau WA, Hinchey EJ: Role of gastric mucosal folds in formation of focal ulcers in the rat. Surgery 91:150–155, 1982
Sanders KM, Szurszewski JH: Does endogenous prostaglandin affect gastric antral motility? Am J Physiol 241(Gastrointest Liver Physiol 4):G191-G195, 1981
Sanders KM, Ross G: Effect of endogenous prostaglandin E on intestinal motility. Am J Physiol 234(2):E204-E208, 1978
Szurszewski JH: Electrical basis for gastrointestinal motility.In Physiology of the Gastrointestinal Tract. LR Johnson (ed). New York, Raven Press, 1981, pp 1435–1466
Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (London), New Biol 231:232–235, 1971
Kim KS, Ridley PT, Tucgel C: Effect of insulin on gastric acid secretion, histamine formation, and on the incidence of gastric lesions. Life Sci 7:403–409, 1968
Koch KL, Dwyer H, Jeffries GH: Dose-response effects of indomethacin and PGE2 on electromechanical activity ofin vivo rabbit ileum. Am J Physiol 250(Gastrointest Liver Physiol 13):G135-G139, 1986
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This study was supported by the Fast Foundation.
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Mersereau, W.A., Hinchey, E.J. Relationship between the gastric myoelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin-treated rats. Digest Dis Sci 33, 200–208 (1988). https://doi.org/10.1007/BF01535734
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DOI: https://doi.org/10.1007/BF01535734