Abstract
We have noted that colons of patients prepared for colonoscopy with Golytely, a nonabsorbable electrolyte lavage solution, frequently contain foam which may obscure small mucosal lesions. Therefore, a randomized, blinded controlled trial was performed to determine the prevalence of Golytely-induced foam and the effect of supplemental simethicone in decreasing the prevalence of foam. Foam was present in 32% of colons prepared with Golytely alone but in none of the colons prepared with Golytely supplemented with simethicone. In addition, only 5% of colons prepared with supplemental simethicone had residual stool noted at the time of colonoscopy, a significant improvement over the 39% prevalence of residual stool in colons prepared with Golytely alone. Addition of simethicone to Golytely lavage decreases the prevalence of colonic foam and residual stool.
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References
Thomas G, Brozinsky S, Isenberg JI: Patient acceptance and effectiveness of a balanced lavage solution (Golytely) versus the standard preparation for colonoscopy. Gastroenterology 82:435–437, 1982
Goldman J, Reichelderfer M: Evaluation of rapid colonoscopy preparation using a new gut lavage solution. Gastrointest Endosc 28:9–11, 1982
Adler M, Quenon M, Even-Adin P, Jeanmart J, VanGossum A, Bourgeois N, Cremer M: Whole gut lavage for colonoscopy-a comparison between two solutions. Gastrointest Endosc 30:65–67, 1984
DiPalma JA, Brady CE, Stewart DL, Karlin DA, McKinney MK, Clement DJ, Coleman TW, Pierson WP: Comparison of colon cleansing methods in preparation for colonoscopy. Gastroenterology 86:856–860, 1984
Ernstoff JJ, DeGrasia A, Marshall JB, Jumshyd A, Mc-Cullough AJ: A randomized blinded clinical trial of a rapid colonic lavage solution (Golytely) compared with standard preparation for colonoscopy and barium enema. Gastroenterology 84:1512–1516, 1983
Hirschowitz BI, Bolt RJ, Pollard HM: Defoaming in gastroscopy with silicone. Gastroenterology 27:649–651, 1954
Gasster M, Westwater JO, Molle WE: Use of a defoaming agent in gastroscopy. Gastroenterology 27:652–655, 1954
Lane N, Kaplan H, Pascal RR: Minute adenomatous and hyperplastic polyps of the colon: Divergent patterns of epithelial growth with specific associated mesenchymal changes. Gastroenterology 60:537–551, 1971
Wayne JD, Frankel A, Braunfeld SF: The histopathology of small colon polyps. Gastrointest Endosc 26:80, 1980 (abstract)
Tedesco FJ, Hendrix JG, Pickens CA, Brady PG, Mills LR: Diminutive polyps: Histopathology, spatial distribution, and clinical significance. Gastrointest Endosc 28:1–5, 1982
Feczko PJ, Bernstein MA, Halpert RD, Ackerman LV: Small colonic polyps: A reappraisal of their significance. Radiology 152:301–303, 1984
Shinya H, Wolff WI: Morphology, anatomic distribution and cancer potential of colonie polyps; an analysis of 7000 polyps endoscopically removed. Ann Surg 190:679–683, 1979
Spencer RJ, Melton LJ, Ready RL, Ilstrup DM: Treatment of small colorectal polyps: A population-based study of the risk of subsequent carcinoma. Mayo Clin Proc 59:305–310, 1984
Wright HK, Pelliccia O, Higgins E, Sreenivas V, Gupta A: Controlled, semielective, segmental resection for massive colonic hemorrhage. Am J Surg 139:535–538, 1980
Richter JM, Hedberg SE, Athanasoulis CA, Schapiro RH: Angiodysplasia: Clinical presentation and colonoscopic diagnosis. Dig Dis Sci 29:481–485, 1984
Hochter W, Weingart J, Kuhner E, Frimberger E, Ottenjam R: Angiodysplasia in the colon and rectum. Endoscopic morphology, localization and frequency. Endoscopy 17:182–185, 1985
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Shaver, W.A., Storms, P. & Peterson, W.L. Improvement of oral colonic lavage with supplemental simethicone. Digest Dis Sci 33, 185–188 (1988). https://doi.org/10.1007/BF01535731
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DOI: https://doi.org/10.1007/BF01535731