Abstract
Collagen is the most abundant protein in the animal world and a principal component, of the extracellular matrix of tissues. Type I collagen is composed of two α 1 chains and one α2 chain. The human α2(I) locus (COL1A2)has been assigned to human chromosome 7q21.3–q22.1. Here, we report the mapping of its murine counterpart Colla-2to mouse chromosome 6 (MMU6) by Southern blotting using somatic cell hybrids. This result disagrees with the previously reported mapping of Colla-2to MMU16 by immunochemical techniques. Our results are supported by comparative mapping data showing conserved homology between regions of human chromosome 7 and mouse chromosome 6.
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Sundaresan, S., Francke, U. Gene forα2(I) collagen is on mouse chromosome 6 not 16. Somat Cell Mol Genet 15, 471–473 (1989). https://doi.org/10.1007/BF01534898
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DOI: https://doi.org/10.1007/BF01534898