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Assignment of retinoblastoma susceptibility gene to mouse chromosome 14

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Somatic Cell and Molecular Genetics

Abstract

A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.

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Authors and Affiliations

  1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78284, San Antonio, Texas

    Chih-Lin Hsieh, Ann M. Killary & Susan L. Naylor

  2. Department of Pathology M-102, School of Medicine, University of California at San Diego, 92093, La Jolla, California

    Wen-Hwa Lee & Eva Y. -H. P. Lee

  3. Center for Molecular Biology, Wayne State University, 48201, Detroit, Michigan

    Peter A. Lalley

Authors
  1. Chih-Lin Hsieh
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  2. Wen-Hwa Lee
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  3. Eva Y. -H. P. Lee
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  4. Ann M. Killary
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  5. Peter A. Lalley
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  6. Susan L. Naylor
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Hsieh, CL., Lee, WH., Lee, E.Y.H.P. et al. Assignment of retinoblastoma susceptibility gene to mouse chromosome 14. Somat Cell Mol Genet 15, 461–464 (1989). https://doi.org/10.1007/BF01534896

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  • DOI: https://doi.org/10.1007/BF01534896

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