Abstract
The hormonally responsive prolactin-inducible protein (PIP), gene is expressed in benign and malignant breast tumor tissues and in such normal exocrine organs as sweat, salivary, and lacrimal glands. In this communication we report the regional chromosome localization of the PIPgene locus to chromosome 7 by Southern hybridization to DNA from human-hamster somatic cell hybrids, and to 7q32–36 by in situ hybridization.
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Literature cited
Welsch, C.W., and Nagasawa, H. (1977).Cancer Res. 37:951–963.
Shiu, R.P.C., and Iwasiow, B.M. (1985).J. Biol. Chem. 260:11307–11313.
Murphy, L.C., Tsuyuki, D., Myal, Y., and Shiu, R.P.C. (1987).J. Biol. Chem. 262:15236–15341.
Murphy, L.C., Lee-Wing, M., Goldenberg, G.J., and Shiu, R.P.C. (1987).Cancer Res 47:4160–4164.
Haagensen, D.E., Jr., and Mazoujian, G. (1986). InDiseases of the Breast, 3rd ed., (ed.) Haagenson, C.D. (W.B. Saunders, Philadelphia), pp. 474–500.
Riddell, D.C., Mallonee, R., Phillips, J.A., Parks, J.S., Sexton, L.A., and Hamerton, J.L. (1985).Somat. Cell Mol. Genet. 2:189–195.
Royle, N.J., Fung, M.R., MacGillavary, R.J.A., and Hamerton, J.L. (1986).Cytogenet Cell. Genet. 41:185–188.
Maniatis, T., Kee, S.G., Efsradiatis, A., and Kafatos, F.C. (1976).Cell 27:583–591.
Lin, C.C., Draper, P.N., and De Brackeleer, M. (1985).Cytogenet. Cell Genet. 39:269–274.
Arrand, J. (1985). InNucleic Acid Hybridization: A Practical Approach, 3rd ed., (eds.) Hames, B.D., and Higgins, S.J. (IRL Press, Washington, D.C.), pp. 21–22.
Reed, K.C., and Mann, D.A. (1985).Nucleic Acids Res. 13:7207–7221.
Wang, H., Riddell, D.C., Guinto, E.R., MacGillivary, R.T.A., and Hamerton, J.L. (1988).Genomics 2:324–328.
Harper, M.A., and Saunders, G.T. (1981).Chromosoma 83:431–439.
Robertson, M., Boyajian, M., Patterson, K., and Robertson, W.V.B. (1986).Endocrinology 119:2439–2443.
Beaudet, A., Bowcock, A., Buchwald, M., Cavalli, P., Sforza, L., Farral, M., King, M.C., Klinger, K., Lalouel, J.M., Lathrop, G., Naylor, S., Ott, J., Tsui, L., Watkins, P., White, R., and Williamson, R., (1986).Am. J. Hum. Genet. 39:681–693.
Quinton, P.M. (1983).Nature 301:421–422.
Knowles, M.R., Gatzy, J.T., and Boucher, R.C. (1983).J. Clin. Invest. 71:1410–1417.
Bell, D.R., Trent, J.M., Willard, H.F., Riodan, J.R., and Ling, V. (1987).Cancer Genet. Cytogenet 25:141–148.
Fairchild, C.R., Ivy, S.P., Kao-Shan, C.S., Whang-Peng, J., Rosen, N., Israel, M.A., Melera, P.W., Cowan, K.H., and Goldsmith, M.E. (1987).Cancer Res. 47:5141–5148.
Berger, R., Bloomfield, C.D., and Sutherland, G.R. (1985).Cytogenet. Cell Genet. 40:490–535.
Yunis, J.J., Soreng, A.L., and Bowe, A.E. (1987).Oncogene 1:59–69.
Le Beau, M.M. (1986).Blood 67:849–858.
Yunis, J.J., and Soreng, A.L. (1984).Science 226:1199–1204.
De Braekeleer, M., Smith, B., and Lin, C.C. (1985).Hum. Genet. 69:112–116.
Gebhart, E., Bruderlein, S., Augustus, M., Siebert, E., Feldner, J., and Schmidt, W. (1986).Treatment Res. 8:125–138.
Rodgers, C.S., Hill, S.M., and Hulten, M.A. (1984).Cancer Genet. Cytogenet 13:95–119.
Wong, Z., Wilson, V., Patel, I., Povey, S., and Jeffreys, A.J. (1987).Ann. Hum. Genet. 51:269–288.
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Myal, Y., Gregory, C., Wang, H. et al. The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. Somat Cell Mol Genet 15, 265–270 (1989). https://doi.org/10.1007/BF01534877
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DOI: https://doi.org/10.1007/BF01534877