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Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice

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Somatic Cell and Molecular Genetics

Abstract

Analysis of mouse serum hyaluronidase by polyacrylamide gel electrophoresis, with the substrate high-molecular-weight hyaluronan (hyaluronic acid) included in the gel performed in mice of two different strains, BALB/cBy and C57BL/6By, reveals a pattern of multiple enzyme forms specific for each genotype. In BALB/c serum, seven different forms are present, only one of which is found in C57BL/6 serum. Segregation analysis of the enzyme polymorphism in backcross progeny and in recombinant inbred and bilineal congenic lines shows that the difference is due to a single locus, which we have designated as Hyal-1. Hyal-1 is linked to the histocompatibility locus H-7, on chromosome 9.

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Authors and Affiliations

  1. Institut Curie-Biologie, Centre Universitaire, Bât. 110, 91405, Orsay, France

    Berta Fiszer-Szafarz & Edward De Maeyer

Authors
  1. Berta Fiszer-Szafarz
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  2. Edward De Maeyer
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Fiszer-Szafarz, B., De Maeyer, E. Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet 15, 79–83 (1989). https://doi.org/10.1007/BF01534672

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  • DOI: https://doi.org/10.1007/BF01534672

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