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Hyaluronan and myeloperoxidase in human peritoneal fluid during genital inflammation

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Abstract

The changes in concentration of hyaluronan (HYA) and myeloperoxidase in peritoneal fluid (PF) were studied during genital intraperitoneal inflammation. PF were collected from 111 women undergoing laparatomy for adhesiolysis and reconstructive surgery of the fallopian tubes, or laparoscopy in search of causes of infertility or low abdominal pain. When the number of leukocytes in the PF had been counted, the fluid samples were centrifuged and the supernatants analyzed for the concentrations of HYA and of myeloperoxidase. During genital inflammation, whether postoperative or postinfectious, leukocytosis and elevated levels of HYA and myeloperoxidase were found in the PF. Concentrations of these substances in the PF may be usable as clinical markers for genital inflammation.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Uppsala University, S-751 85, Uppsala, Sweden

    Greta A. B. Edelstam & Örjan Lundkvist

  2. Department of Clinical Chemistry, Uppsala University, S-751 85, Uppsala, Sweden

    Per Venge

  3. Department of Medical and Physiological Chemistry, Uppsala University, S-751 85, Uppsala, Sweden

    Torvard C. Laurent

Authors
  1. Greta A. B. Edelstam
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  2. Örjan Lundkvist
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  3. Per Venge
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  4. Torvard C. Laurent
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Additional information

Supported by grants from the Swedish Medical Research Council (03X-4, 17X-3495, 03X-4954) and from “Förenade Liv” Mutual Group Life Insurance Company, Stockholm, Sweden.

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Edelstam, G.A.B., Lundkvist, Ö., Venge, P. et al. Hyaluronan and myeloperoxidase in human peritoneal fluid during genital inflammation. Inflammation 18, 141–149 (1994). https://doi.org/10.1007/BF01534555

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