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In situ localization of murinec-Ki-ras-2 oncogene: Preliminary evidence for conservation of telomeric territory of oncogenes?

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Somatic Cell and Molecular Genetics

Abstract

The use of a human cDNA probe and a Robertsonian translocation marker allowed us to localize the murinec-Ki-ras-2 oncogene to 6F-G at the telomere. Our finding provides support for the hypothesis that oncogenes have a preferred telomeric territory that is evolutionarily conserved. Given our physical mapping ofc-Ki-ras-2 to 6F-G, the role of this oncogene in the genesis and/or maintenance of granulocytic leukemias can now be explored by correlating the oncogenic site to that of the structural rearrangement of chromosome 6 seen in the tumors.

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Literature cited

  1. Klein, G. (1981.Nature 294:313–318.

    PubMed  Google Scholar 

  2. Rowley, J.D. (1982).Science 216:749–751.

    PubMed  Google Scholar 

  3. Erickson, J., ar-Rushdi, A., Drwinga, H.L., Nowell, P.C., and Croce, C.M. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:820–824.

    PubMed  Google Scholar 

  4. Croce, C.M., Theirfelder, W., Erickson, J., Nishikara, K., Finan, J., Lenoir, G.M., and Nowell, P.C. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:6922–6926.

    PubMed  Google Scholar 

  5. Erickson, J., Nishikura, K., ar-Rushdi, A., Finan, J., Emanuel, B., Lenoir, G., Nowell, P.C., and Croce, C.M. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:7581–7585.

    PubMed  Google Scholar 

  6. Heisterkamp, N., Stephenson, J.R., Groffen, J., Hansen, P.F., deKlein, A., Bartram, C.R., and Grosveld, G. (1983).Nature 306:239–242.

    PubMed  Google Scholar 

  7. Shtivelman, E., Lifshitz, B., Gale, R.P., and Canaani, E. (1985).Nature 315:550–554.

    PubMed  Google Scholar 

  8. Konopka, J.B., Watanabe, S.M., Singer, J.W., Collins, S.J., and Witte, O.N. (1985).Proc. Natl. Acad. Sci. U.S.A. 82:1810–1814.

    PubMed  Google Scholar 

  9. Lalley, P.A., and McKusick, V.A. (1985). Report of the committee on comparative gene mapping. Eighth International Workshop on Human Gene Mapping.Cytogenet. Cell Genet. 40:536–566.

    PubMed  Google Scholar 

  10. Weiner, F., Spira, J., Banerjee, M., and Klein, G. (1985).Somat. Cell Mol. Genet. 11:493–498.

    PubMed  Google Scholar 

  11. Cheng, Z.Y., Lovett, M., Epstein, L.B., and Epstein, C.J. (1986).Cytogenet. Cell Genet. 41:101–106.

    PubMed  Google Scholar 

  12. Baranov, V.S., Schwartzman, A.L., Gorbunova, V.N., Gaifskhoki, V.S., and Neifakh, S.A. (1985).Genetika 21:409–419.

    PubMed  Google Scholar 

  13. Lima-de-Faria, A., and Mitelman, F. (1986).Biosci. Rep. 6:349–354.

    PubMed  Google Scholar 

  14. Eicher, E.M., and Washburn, L.L. (1978).Proc. Natl. Acad. Sci. U.S.A. 75:946–950.

    PubMed  Google Scholar 

  15. Harper, M.E., and Saunders, G.F. (1981).Chromosoma 83:431–439.

    PubMed  Google Scholar 

  16. Martin-DeLeon, P.A., Wolf, S.F., Persico, G., Toniolo, D., Martini, G., and Migeon, B.R. (1985).Cytogenet. Cell Genet. 39:87–92.

    PubMed  Google Scholar 

  17. Cannizzaro, L.A., and Emanuel, B.S. (1984).Cytogenet. Cell Genet. 38:308–309.

    PubMed  Google Scholar 

  18. Davisson, M.T., and Roderick, T.H. (1986).Mouse News Lett. 75:11–15.

    Google Scholar 

  19. Cahilly, L.A., and George, D.L. (1985).Cytogenet. Cell Genet. 39:140–144.

    PubMed  Google Scholar 

  20. Dexter, T.M., Allen, T.D., Scott D., and Teich, N.M. (1979).Nature 277:471–474.

    PubMed  Google Scholar 

  21. Scolnick, E.M., Weeks, M.O., Shih, T.Y., Ruscetti, S.K., and Dexter, T.M. (1981).Mol. Cell. Biol. 1:66–74.

    PubMed  Google Scholar 

  22. Popescu, N.C., Amsbaugh, S.C., DiPaolo, J.A., Tronick, S.R., Aaronson, S.A., and Swan, D.C. (1985).Somat. Cell Mol. Genet. 11:149–155.

    PubMed  Google Scholar 

  23. Grzeschik, K.-H., and Kazazian, H.H. (1985). Report of the Committee on the Genetic Constitution of Chromosomes 10, 11, and 12. Eighth International Workshop on Human Gene Mapping.Cytogenet. Cell Genet. 40:179–205.

    PubMed  Google Scholar 

  24. Francke, U., and Taggart, R.T. (1980).Proc. Natl. Acad. Sci. U.S.A. 77:3595–3599.

    PubMed  Google Scholar 

  25. Migeon, B.R., Brown, T.R., Axelman, J., and Migeon, C.J. (1981).Proc. Natl. Acad. Sci. U.S.A. 78:6339–6343.

    PubMed  Google Scholar 

  26. Nadeau, J.H., Franklin, G.B., Kelly, K.A., Pitha, P.M., Sidman, C.L., and Worrall, N. (1986).Genetics 104:1239–1255.

    Google Scholar 

  27. Adolph, S., Bartram, C.R., and Hameister, H. (1987).Cytogenet Cell Genet. 44:65–68.

    PubMed  Google Scholar 

  28. Nesbitt, M.N., and Francke, U. (1973).Chromosoma 41:145–158.

    PubMed  Google Scholar 

  29. Hayata, I., Seki, M., Yoshida, K., Hirashima, K., Sado, T., Yamagiwa, J., and Ishihara, T. (1983).Cancer Res. 43:367–373.

    PubMed  Google Scholar 

  30. Sakaguchi, A.Y., Lalley, P.A., Zabel, B.U., Ellis, R.W., Scolnick, E.M., and Naylor, S.L. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:525–529.

    PubMed  Google Scholar 

  31. Schwab, M., Alitalo, K., Varmus, H.E., Bishop, J.M., and George, D. (1983).Nature 303:497–501.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Life and Health Sciences, University of Delaware, 19716, Newark, Delaware

    Patricia A. Martin-DeLeon & Sheila R. Picciano

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  1. Patricia A. Martin-DeLeon
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  2. Sheila R. Picciano
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Martin-DeLeon, P.A., Picciano, S.R. In situ localization of murinec-Ki-ras-2 oncogene: Preliminary evidence for conservation of telomeric territory of oncogenes?. Somat Cell Mol Genet 14, 205–210 (1988). https://doi.org/10.1007/BF01534405

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  • DOI: https://doi.org/10.1007/BF01534405

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