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Effects of CD4+ and CD8+ T cells in tumor-bearing mice on antibody production

  • Short Communication
  • Tumor Bearing, Mice Anti-SRBC Antibody, CD4+ T Cell, CD8+ T Cell Immunosuppression
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Abstract

The function of T cell subsets in tumor-bearing mice was examined using an in vitro culture system of anti-(sheep red blood cell) antibody production, which is known to be dependent on T cells. The helper function of T cells of fibrosarcoma-MethA-bearing mice in antibody production decreased with the tumor stage of the mice. T cells were separated into CD4+ and CD8+ cells for further analysis of T cell subsets by the panning method using monoclonal antibodies. The helper function of CD4+ T cells in antibody production began to decrease significantly in tumor-bearing mice 1 week after the tumor transplantation. On the other hand, the suppressive function of CD8+ T cells was retained and had not decreased in the mice even 3 weeks after the transplantation. The same changes in function of CD4+ and CD8+ T cells were also observed in Methl-bearing mice. These results suggested that this tumor-associated immunosuppression in antibody production is attributable to the decrease in helper activity of CD4+ T cells and the maintenance of the suppressive activity of CD8+ T cells.

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  1. Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-ku, Tokyo, Japan

    Motomu Shimizu & Takao Iwaguchi

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  1. Motomu Shimizu
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  2. Takao Iwaguchi
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Shimizu, M., Iwaguchi, T. Effects of CD4+ and CD8+ T cells in tumor-bearing mice on antibody production. Cancer Immunol Immunother 38, 272–276 (1994). https://doi.org/10.1007/BF01533519

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  • DOI: https://doi.org/10.1007/BF01533519

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