Immune abnormalities in patients with autism
We have begun an investigation on the immune systems of patients with autism in attempt to determine if immune mechanisms are involved in the development of this severe developmental disorder. A study of 31 autistic patients has revealed several immune-system abnormalities, including reduced responsiveness in the lymphocyte blastogenesis assay to phytohemagglutinin, concanavalin A, and pokeweed mitogen; decreased numbers of T lymphocytes; and an altered ratio of helper to suppressor T cells. Immune-system abnormalities may be directly related to underlying biologic processes of autism, or these changes may be an indirect reflection of the actual pathologic mechanism.
Unable to display preview. Download preview PDF.
- Renoux, G. (1984). Brain neocortex and the immune system.Immunology Today, 5, 218.Google Scholar
- Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L., & Stein, M. (1985). Depression and immunity: Lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients and patients hospitalized for herniorrhaphy.Archives of General Psychiatry, 42, 129–133.PubMedGoogle Scholar
- Thomas, Y., Rogozinski, L., Irgoyen, O. H., Friedman, S. H., Kung, P. C., & Schess, L. (1981). Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4 + population.Journal of Experimental Medicine, 154, 459–467.PubMedGoogle Scholar
- Waksman, B. H. (1981). Current trends in multiple sclerosis research.Immunology Today, 2, 87–93.Google Scholar
- Yates, A. (1984). Autism: The case for left hemispheric damage.Arizona Medicine, 16, 395–397.Google Scholar