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Infantile autism associated with the Fragile-X syndrome

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Abstract

A 6-year-old mentally retarded child presented with a clinical picture consistent with the diagnosis of childhood autism. Chromosomal studies revealed a male karyotype with approximately 11% of the cells counted containing a fragile site on the X chromosome. The possibility of a syndrome of autism occurring in children with the Fragile-X syndrome is discussed.

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Reference notes

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Authors and Affiliations

  1. Harvard Medical School, USA

    David L. Meryash,  Ludwik S. Szymanski & Park S. Gerald

Authors
  1. David L. Meryash
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  2. Ludwik S. Szymanski
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  3. Park S. Gerald
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Additional information

This work was supported in part by the U.S. Department of Health and Human Services, Maternal and Child Health Project No. 928, the Administration on Developmental Disabilities grant No. 59-P-05163, NIH grant HD-04807, and the Children's Hospital Mental Retardation Center CORE grant HD-06276. Our sincere thanks to Dr. Edward Ritvo for his permission to refer to his as yet unpublished data. Appreciation is expessed to Dr. Allen Crocker, director; Dr. Leslie Rubin, staff pediatrician; and the team members of the Developmental Evaluation Clinic for their help in evaluating this patient and in preparation of this paper.

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Meryash, D.L., Szymanski, L.S. & Gerald, P.S. Infantile autism associated with the Fragile-X syndrome. J Autism Dev Disord 12, 295–301 (1982). https://doi.org/10.1007/BF01531374

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