Follow-up report on autism in congenital rubella

Abstract

A longitudinal study was conducted of 243 children with congenital rubella. In this sample a high rate of autism and a high rate of recovery were observed. Examination of the data suggested that the rubella virus was the primary etiologic agent. It is hypothesized that the course of autism was that of a chronic infection in which recovery, chronicity, improvement, worsening, and delayed appearance of the autistic syndrome all were found. Other rubella consequences such as blindness, deafness, and cardiac and neuromuscular defects remained present except as modified by operations and prostheses. Degree of mental retardation initially was related to the outcome of autism but shifts in mental retardation over time did not correlate significantly for the group with shift in the autistic symptoms.

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References

  1. Barr, D. G. D. Infections. In F. Cockburn & C. Drillien (Eds.),Neonatal medicine, London: Blackwell Scientific Publications, 1974. Pp. 656–659.

    Google Scholar 

  2. Chess, S. Autism in children with congenital rubella.Journal of Autism and Childhood Schizophrenia, 1971,1, 33–47.

    Google Scholar 

  3. Chess, S., Korn, S. J., & Fernandez, P.Psychiatric disorders of children with congenital rubella. New York: Brunner/Mazel, 1971.

    Google Scholar 

  4. Desmond, M., Wilson, G. S., Melnick, J. L., et al. Congenital rubella encephalitis.Journal of Pediatrics, 1967,71, 311–331.

    Google Scholar 

  5. Lotter, V. Services for a group of autistic children in Middlesex. In J. K. Wing (Ed.),Early childhood autism. Oxford: Pergamon Press, 1966. Pp. 241–256.

    Google Scholar 

  6. Mindel, E., & Vernon, M.They grow in silence. Silver Springs, Maryland: National Association of the Deaf, 1971.

    Google Scholar 

  7. Rutter, M. The development of infantile autism.Psychological Medicine, 1974,4, 147–163.

    Google Scholar 

  8. Townsend, J. J., Baringer, J. R., Wolinsky, J. S., et al. Progressive rubella panencephalitis: Late onset after congenital rubella.New England Journal of Medicine, 1975,292, 990–993.

    Google Scholar 

  9. Treffert, D. A. Epidemiology of infantile autism.Archives of General Psychiatry, 1970,22, 431–438.

    Google Scholar 

  10. Weil, M. L., Itabashi, H., & Cremer, N. E. Chronic progressive panencephalitis due to rubella virus simulating subacute sclerosing panencephalitis.New England Journal of Medicine, 1975,292, 994–998.

    Google Scholar 

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Chess, S. Follow-up report on autism in congenital rubella. J Autism Dev Disord 7, 69–81 (1977). https://doi.org/10.1007/BF01531116

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Keywords

  • Longitudinal Study
  • Mental Retardation
  • Blindness
  • Chronic Infection
  • Rubella