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Immune reconstitution following bone marrow transplantation

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  • Immune Reconstitution, Bone Marrow Transplantation
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References

  1. Agah R, Mazumder A (1989) The potential usefulness of interleukin-2 activated bone marrow cells as an active therapeutic tool against cytomegalovirus infection in a bone marrow transplant setting. J Clin Immunol 9: 223

    PubMed  Google Scholar 

  2. Agah R, Malloy B, Kerner M, Mazumder A (1989) Generation and characterization of IL-2 activated bone marrow cells as a potent graft vs leukemia effector in transplantation. J Immunol 143: 3093

    PubMed  Google Scholar 

  3. Agah R, Malloy B, Kerner M, Girgis E, Bean P, Twoney P, Mazumder A (1989) Potent graft antitumor effect in natural killerresistant disseminated tumors by transplantation of interleukin-2 activated syngeneic bone marrow in mice. Cancer Res 49: 5959

    PubMed  Google Scholar 

  4. Antin JH, Ault KA, Rappeport JM, Smith BR (1987) Blymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes. J Clin Invest 80: 325

    PubMed  Google Scholar 

  5. Atkinson K (1990) Reconstitution of the hemopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 5: 2091

    Google Scholar 

  6. Atkinson K, Storb R, Prentiss RL, Witherspoon RP, Sullivan K, Noel D, Thomas ED (1979) Analysis of late infections in 89 long term survivors of bone marrow transplantation. Blood 53: 7201

    Google Scholar 

  7. Atkinson K, Hanson JA, Storb R, Goehle S, Goldstein G, Thomas ED (1992) T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets. Blood 59: 1292

    Google Scholar 

  8. Ault KA, Antin JH, Ginsberg D, Orkin SH, Rapperport JM, Keohan ML, Martin P, Smith BR (1985) Phenotype of recovering lymphoid cell populations after marrow transplantation. J Exp Med 161: 1483

    PubMed  Google Scholar 

  9. Bar BMAM, Schattenberg A, Mensink EJBM, Kessel AGV, Smetsers TFCM, Knops GHJN, Linders EHP, Witte TD (1993) Donor leukocyte infusions for chronic myeloid leukemia relapsed after allogeneic bone marrow transplantation. J Clin Oncol 11: 513

    PubMed  Google Scholar 

  10. Bengtsson M, Gordan J, Flores-Romo L, Cairns JA, Smedmyr B, Oberg G, Simonsson B, Totterman TH (1989) B-cell reconstitution after autologous bone marrow transplantation: increase in serum CD23 (“IgE-binding factor”) precedes IgE and B-cell regeneration. Blood 73: 2139

    PubMed  Google Scholar 

  11. Bengtsson M, Smedmyr B, Festin R, Oberg S, Simonson B, Totterman TA (1989) B-lymphocyte regeneration in marrow and blood after autologous BMT: increased numbers of B-cells carrying activation and progression markers. Leuk Res 13: 791

    PubMed  Google Scholar 

  12. Bensinger WI, Price TH, Dale DC, Appelbaum FR, Clift R, Lilleby K, Williams B, Storb R, Thomas ED, Buckner CD (1993) The effects of daily recombinant human granulocyte colony stimulating factor administration on normal granulocyte donors undergoing leukapheresis. Blood 81: 1883

    PubMed  Google Scholar 

  13. Blaise D, Olive D, Stoppa AM, Viens P, Poureau C, Lopez M, Attal M, Jasmin C, Monges G, Mawas C, Mannoni P, Palmer P, Franks C, Philip T, Maraninchi D (1990) Hematologie and immunological effects of the systemic administration of recombinant interleukin-2 after autologous bone marrow transplantation. Blood 76: 1092

    PubMed  Google Scholar 

  14. Bortin MM, Rimm AA (1977) Severe combined immunodeficiency disease. Characterization of the disease and results of transplantation. JAMA 238: 591

    PubMed  Google Scholar 

  15. Bosserman LD, Murray C, Takvorian T, Anderson KC, Freedman AS, Fitzsimmons J, Coral F, Madler LM, Schlossman SF, Ritz J (1989) Mechanism of graft failure in HLA matched and HLA mismatched bone marrow transplant recipients. Bone Marrow Transplant 4: 239

    PubMed  Google Scholar 

  16. Bowden RA, Day LM, Amos DE, Meyers JD (1986) Natural cytotoxic activity against cytomegalovirus-infected target cells following marrow transplantation. Transplantation 44: 504

    Google Scholar 

  17. Brandwein JM, Nayer R, Baker MA, Sutton DM, Scott JG, Sutcliffe SB, Keating A (1991) GM-CSF therapy for delayed engraftment after autologous bone marrow transplantation. Exp Hematol 19: 191

    PubMed  Google Scholar 

  18. Brenner MK, Wimperis JZ, Reittie JE, Patterson J, Asherson GL, Hoffbrand AV, Prentice HG (1986) Recovery of immunoglobulin isotypes following T-cell-depleted allogeneic bone marrow transplantation. Br J Haematol 64: 125

    PubMed  Google Scholar 

  19. Brkic S, Tsoi M-S, Mori T, Lactiman L, Gillis S, Thomas ED, Storb R (1985) Cellular interaction in marrow grafted patients. III. Normal interleukin 1 and defective interleukin 2 production in short term and in those with chronic graft-versus-host disease. Transplantation 39: 30

    PubMed  Google Scholar 

  20. Buckley RH, Schiff SE, Sampson HA, Shiff RI, Markert ML, Knutsen AP, Hershfield MS, Huang AT, Mickey GH, Ward FE (1986) Development of immunity in human severe primary T-cell deficiency following haploidentical bone marrow stem cell transplantation. J Immunol 136: 2398

    PubMed  Google Scholar 

  21. Butturini A, Seeger RC, Gale RP (1986) Recipient immune-competent T-lymphocytes can survive intensive conditioning for bone marrow transplantation. Blood 68: 954

    PubMed  Google Scholar 

  22. Carney WP, Rubin RH, Hoffman RA, Hansen WP, Healey K, Hirsch MS (1981) Analysis of lymphocyte subsets in cytomegalovirus mononucleosis. J Immunol 126: 2114

    PubMed  Google Scholar 

  23. Cayeux S, Meuer S, Pezzutto A, Korbling M, Haas R, Schulz R, Dorken B (1989) T-cell ontogeny after autologous bone marrow transplantation: failure to synthesize interleukin-2 (IL-2) and lack of CD2- and CD3-mediated proliferation by both CD4+ and CD8+ cells even in the presence of exogenous IL-2. Blood 74: 2270

    PubMed  Google Scholar 

  24. Champlin R (1990) T-cell-depletion to prevent graft-versus-host disease after bone marrow transplantation. Hematol Oncol Clin North Am 4: 687

    PubMed  Google Scholar 

  25. Champlin R (1992) Graft-versus-leukemia without graft-versushost disease: an elusive goal of bone marrow transplantation. Semin Hematol 29: 46

    PubMed  Google Scholar 

  26. Champlin R, Ho W, Gajewski J, Feig S, Burnison M, Holley G, Greenberg P, Lee K, Schmid I, Giorgi J, Yam P, Petz L, Winston D, Warner N, Reichert T (1990) Selective depletion of CD8+ T-lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood 76: 418

    PubMed  Google Scholar 

  27. Charak BS, Byrnes RK, Groshen S, Chen S-C, Mazumder A (1990) Bone marrow transplantation with interleukin-2 activated bone marrow followed by interleukin-2 therapy for acute myeloid leukemia in mice. Blood 76: 2187

    PubMed  Google Scholar 

  28. Charak BS, Choudhary GD, Tefft M, Mazumder A (1992) Interleukin-2 in bone marrow transplantation: preclinical studies. Bone Marrow Transplant 10: 103

    PubMed  Google Scholar 

  29. Charak BS, Agah R, Mazumder A (1992) Synergism of interleukin-2 and cyclosporine A in induction of graft versus host disease after syngeneic bone marrow transplantation. Blood 79: 179

    Google Scholar 

  30. Chen W, Peace DJ, Rovira DK, You SG, Cheever MA (1992) T-cell immunity to the joining region of p210BCR-ABL protein. Proc Natl Acad Sci USA 89: 1468

    PubMed  Google Scholar 

  31. Clark RA, Johnson FL, Klebanoff SJ, Thomas ED (1976) Defective neutrophil chemotaxis in marrow transplant patients. J Clin Invest 58: 22

    PubMed  Google Scholar 

  32. Conley Me (1991) X-linked severe combined immunodeficiency. Clin Immunol Immunopathol 61: S94

    Google Scholar 

  33. Cooley MA, Atkinson K, Adamthwaite D (1991) In vitro function of CD4+ cells of naive and memory phenotype in bone marrow transplant recipients. Transplant Proc 23: 165

    PubMed  Google Scholar 

  34. De Bruin HG, Astaldi A, Leupers T, Grind RJ van de, Doreen LJ, Schelleken PTA, Tanke HJ, Roos M, Vossen JM (1981) T-lymphocyte characteristics in bone marrow transplanted patients. II. Analysis with monoclonal antibodies. J Immunol 127: 244

    PubMed  Google Scholar 

  35. Deeg HJ, Storb R (1984) Graft versus host disease: pathophysiological and clinical aspects. Annu Rev Med 35: 11

    PubMed  Google Scholar 

  36. Delmon L, Ythier P, Moingeon P, Nowill A, Bayle C, Pico JL, Hayat M, Ritz J, Hercand TH (1986) Characterization of antileukemia cells' cytotoxic effector function: implication for monitoring natural killer responses following allogeneic bone marrow transplantation. Transplantation 42: 252

    PubMed  Google Scholar 

  37. Elfenbein GJ, Anderson PN, Humphrey RL, Mullens GM, Sensenbrenner LL, Wands JR, Santos GW (1976) Immune system reconstitution following allogeneic bone marrow transplantation in man: A multiparameter analysis. Transplant Proc 8: 641

    PubMed  Google Scholar 

  38. Elfenbein GJ, Adams JS, Bellis MM, Santos GW, Smith KA (1984) Role of interleukin-2 in depressed T-cell mitogenesis after allogeneic marrow transplantation in man. Leuk Res 8: 417

    PubMed  Google Scholar 

  39. Engelhard D, Nagler A, Hardan I, Morag A, Aker M, Baciu H, Strauss N, Parag G, Naparstek E, Ravid Z, Or R, Slavin S, Zakay-Rones Z (1993) Antibody response to a two dose regimen of influenza vaccine in allogeneic T-cell-depleted and autologous BMT recipients. Bone Marrow Transplant 11: 1

    Google Scholar 

  40. Fass L, Ochs HD, Thomas ED, Mickelson E, Storb R, Fefer A (1973) Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man. Transplantation 16: 630

    PubMed  Google Scholar 

  41. Filipovich AH, Shapiro RS, Ramsay NKC, Kim T, Blazar B, Kersey J, McGlave P (1992) Untelated donor bone marrow tansplantation for correction of lethal congenital immunodeficiencies. Blood 80: 270

    PubMed  Google Scholar 

  42. Fisher A, Landais B, Friedrich W, Morgan G, Gerritsen B, Fasth A. Porta F, Criscelli C, Goldman SF, Levinsky R, Vossen J (1990) European experience of bone marrow transplantation for SCID. Lancet 336: 850

    PubMed  Google Scholar 

  43. Fox R, McMillan R, Spruce W, Tani P, Mason D (1982) Analysis of T-lymphocytes after bone marrow transplantation using monoclonal antibodies. Blood 60: 578

    PubMed  Google Scholar 

  44. Friedrich W, O'Reilly RJ, Koziner B, Gebhard DF Jr, Good RA, Evans RL (1982) T-lymphocyte reconstitution in recipients of bone marrow transplants with and without GVHD: imbalances of T-cell subpopulation having unique regulatory and cognitive functions. Blood 59: 696

    PubMed  Google Scholar 

  45. Gabrilove J (1992) The development of granulocyte colony-stimulating factor in its various clinical applications. Blood 80: 1382

    PubMed  Google Scholar 

  46. Gale RP, Champlin RE (1984) How does bone marrow transplantation cure leukemia? Lancet II: 28

    Google Scholar 

  47. Gale RP, Sparkes RS, Golde DW (1978) Bone marrow origin of hepatic macrophages (Kupffer cells) in human. Science 201: 937

    PubMed  Google Scholar 

  48. Glazier A, Tutschka PJ, Farmer ER, Santos GW (1983) Graft-versus host disease in cyclosporine A rats after syngeneic and autologous bone marrow reconstitution. J Exp Med 158: 1

    PubMed  Google Scholar 

  49. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft versus host disease in human recipients of marrow from MHC-matched sibling donors. Transplantation 18: 295

    PubMed  Google Scholar 

  50. Graham-Pole J, Camitta B, Casper J, Elfenbein G, Gross S, Herzig R, Koch P, Mahoney R, Marcus R, Munoz L, Pick T, Spruce W, Steuber P, Weiner R (1988) IVIG may lessen all forms of infections in patients receiving allogeneic BMT for acute lymphoblastic leukemia: a pediatric oncology group study. Bone Marrow Transplant 3: 559

    PubMed  Google Scholar 

  51. Grebe SC, Streilein JW (1976) Graft-versus-host disease. Adv Immunol 22: 119

    PubMed  Google Scholar 

  52. Halterman RH, Graw RG Jr, Fuccilo DA, Leventhal BG (1972) Immunocompetence following allogeneic bone marrow transplantation in man. Transplantation 14: 689

    PubMed  Google Scholar 

  53. Hamon MD, Prentice HG, Gottlieb DJ, Macdonald ID, Cunningham JM, Smith OP, Gilmore M, Gandhi L, Collis C (1993) Immunotherapy with interleukin 2 after ABMT in AML. Bone Marrow Transplant 11: 399

    PubMed  Google Scholar 

  54. Hercand T, Takvorian T, Nowill A, Tantravahi R, Moingeon P, Anderson KC, Murray C, Bohuon C, Ythier A, Ritz J (1986) Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation. Blood 67: 722

    PubMed  Google Scholar 

  55. Heslop HE, Gottlieb DJ, Reittie JE, Bello-Fernandez C, Meager A, Prentice HG, Brenner MK (1989) Spontaneous and interleukin-2 induced secretion of tumor necrosis factor and gamma interferon following autologous bone marrow transplantation or chemotherapy. Br J Hematol 72: 122

    Google Scholar 

  56. Hess AD, Horwitz L, Beschorner WE, Santos GW (1985) Development of graft-vs-host disease-like syndrome in cyclosporine treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T-lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity. J Exp Med 161: 718

    PubMed  Google Scholar 

  57. Holland HK, Wingard JR, Beschorner WE, Saral R, Santos J (1988) Broncholitis obliterans in bone marrow transplantation and its relationship to chronic graft-vs-host disease and low serum IgG. Blood 72: 621

    PubMed  Google Scholar 

  58. Hooton JWL, Miller CL, Melgrasen CD, Bleackley RC, Gillis S, Paetkau V (1990) Development of precytotoxic T-cells in cyclosporine-suppressed mixed lymphocytes reactions. J Immunol 144: 816

    PubMed  Google Scholar 

  59. Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb H-J, Rimm AA, Ringden O, Rozman C, Speck B, Truitt RL, Zwaan FE, Bortin MM (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75: 555

    PubMed  Google Scholar 

  60. Jacobs R, Stoll M, Stratman G, Leo R, Rink H, Schmidt RE (1992) CD16-CD56+ natural killer cells after bone marrow transplantation. Blood 79: 3239

    PubMed  Google Scholar 

  61. Janossy G, Prentice HG, Grob JP, Ivory K, Tidman N, Grundy J, Favrot M, Brenner M, Campana D, Blacklok HA, Gilmore MJML, Patterson J, Griffiths PH, Hoffband AV (1986) T lymphocyte regeneration after transplantation of T-cell depleted allogeneic bone marrow. Clin Exp Immunol 63: 577

    PubMed  Google Scholar 

  62. Jin N, Lum LG (1987) IgG anti-tetanus toxoid antibody production induced by Epstein-Barr virus from B-cells of human marrow transplant recipients. Cell Immunol 101: 266

    Google Scholar 

  63. Kagan J, Champlin RE, Saxon A (1989) B-cell dysfunction following human bone marrow transplantation: functional-phenotypic dissociation in the early post transplant period. Blood 74: 777

    PubMed  Google Scholar 

  64. Keable H, Bourhis JH, Brison O, Lehn P, Schenmetzler C, Devergie A, Gluckman E (1989) Long term study of chimerism in bone marrow transplant recipients for severe aplastic anemia. Br J Haematol 71: 525

    PubMed  Google Scholar 

  65. Keever CA, Small TN, Flomenberg N, Heller G, Pekle K, Black P, Pecora A, Gillio A, Kerman NA, O'Reilly RJ (1989) Immune reconstitution following bone marrow transplantation: comparison of recipients of T-cell depleted marrow with recipients of conventional marrow grafts. Blood 73: 1340

    PubMed  Google Scholar 

  66. Keever CA, Pekle K, Gazzola MV, Collins NH, Gillio A (1990) NK and LAK activities from human marrow progenitors. I. The effects of interleukin-2 and interleukin-1. Cell Immunol 126: 211

    PubMed  Google Scholar 

  67. Kolb HJ, Mittermuler J, Clemm Ch, Holler E, Ledderrose G, Brehm G, Heim M, Wilmanns W (1990) donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76: 2462

    PubMed  Google Scholar 

  68. Korngold R, Sprent J (1987) T-cell subsets and graft-versus-host disease. Rransplantation 44: 335

    Google Scholar 

  69. Kwak LW, Campbell MJ, Levy R (1992) Tumor resistance induced by syngeneic bone marrow transplantation and enhanced by interleukin 2: a model for the graft versus leukemia reaction. Cancer Res 52: 4117

    PubMed  Google Scholar 

  70. Kwak LW, Campwell MJ, Czerwinski DK, Hart S, Miller RA, Levy R (1992) Induction of immune responses in patients with B-cell-lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Eng J Med 327: 1209

    Google Scholar 

  71. Linch DC, Knott LJ, Thomas RM, Harper P, Goldstone AH, Davis EG, Levinsky RJ (1983) T-cell regeneration after allogeneic and autologous bone marrow transplantation. Br J haematol 53: 451

    PubMed  Google Scholar 

  72. Livnat S, Seigneuret M, Storb R, Prentice R (1980) Analysis of cytotoxic effector cell function in patients with leukemia or aplastic anemia before and after bone marrow transplantation. J Immunol 124: 481

    PubMed  Google Scholar 

  73. Ljungman P, Fridell E, Lonnqvist B, Bolme P, Bottiger M, Gahrton G, Linde A, Ringden O, Wahren B (1989) Efficacy and safety of vaccination on marrow transplant recipients with live attenuated measles, mumps and rubella vaccine. J Infect Dis 159: 610

    PubMed  Google Scholar 

  74. Ljungman P, Wiklund-Hammarsten M, Duraj V, Hammarstrom L, Lonnqvist B, Paulin T, Ringden O, Pepe MS, Gahrton G (1990) Response to tetanus toxoid immunization after allogeneic bone marrow transplantation. J Infect Dis 162: 496

    PubMed  Google Scholar 

  75. Ljungman P, Duraj V, Magnius L (1991) Response to immunization against polio after allogeneic marrow transplantation. Bone Marrow Transplant 7: 89

    PubMed  Google Scholar 

  76. Lum LG (1987) The kinetics of immune reconstitution after human marrow transplantation. Blood 69: 369

    PubMed  Google Scholar 

  77. Lum LG, Ueda M (1992) Immunodeficiency and the role of suppressor cells after human bone marrow transplantation. Clin Immunol Immunopathol 63: 103

    PubMed  Google Scholar 

  78. Lum LG, Orcutt-Thordarson N, Sergneuret MC, Storb R (1982) The regulation of Ig synthesis after marrow transplantation. IV. T4 and T8 subset function in patients with chronic graft-versus-host disease. J Immunol 129: 113

    PubMed  Google Scholar 

  79. Maraninchi D, Gluckman E, Blaise D, Maraninchi D, Gluckman E, Blaise D, Guyotat D, Rio B, Pico JL, Leblond V, Michallet M, Dreyfus E, Ifrah N (1987) Impact of T-cell depletion on outcome of allogeneic bone marrow transplantation for standard-risk leukemias. Lancet II: 175

    Google Scholar 

  80. Marmont AM, Horowitz MM, Gale RP, Sobocinski K, Ash RC, Bekkum DW van, Champlin RE, Dicke KA, Goldman JM, Good RA, Herzig RH, Hong R, Masaoka T, Rimm AA, Ringden O, Speck B, Weiner RS, Bortin MM (1991) T-cell depletion of HLA-identical transplants in leukemia. Blood 78: 2120

    PubMed  Google Scholar 

  81. Matsue K, Lum LG, Witherspoon RP, Storb R (1987) Proliferative and differentiative response of B-cells from human marrow graft recipients to T-cell-derived factors. Blood 69: 208

    Google Scholar 

  82. Meyers JD, Flournoy N, Thomas ED (1980) Cytomegalovirus infection and specific cell mediated immunity after marrow transplant. J Infect Dis 142: 816

    PubMed  Google Scholar 

  83. Meyers JD, Flournoy N, Thomas ED (1986) Risk factor for cytomegalovirus infections after human marrow transplantation. J Infect Dis 153: 478

    PubMed  Google Scholar 

  84. Mitsuyasu RT, Champlin RE, Gale RP, Ho WG, Lenarsky C, Winston D, Selch M, Elashoff R, Giorgi JV, Wells J, Terasaki P, Billing R, Feig S (1986) Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graftversus-host disease: a prospective randomized double-blind trial. Ann Intern Med 105: 20

    PubMed  Google Scholar 

  85. Mitus AJ, Stein R, Rappeport JM, Antin JH, Weinstein HJ, Alper CA, Smith BR (1989) Monoclonal oligoclonal gammopathy after bone marrow transplantation. Blood 74: 2764

    PubMed  Google Scholar 

  86. Moller J, Dickmeiss E, Ryder LP, Jacobsen N, Svejgaard A (1991) Increased frequencies of the CD29 and CD57 markers and decreased frequency of CD45RA within CD4+ and CD8+ subsets after allogeneic bone marrow transplantation in man. Scan J Immunol 33: 499

    Google Scholar 

  87. Mori T, Tsoi M-S, Gillis S, Santos E, Thomas ED, Storb R (1983) Cellular interaction in marrow grafted patients. I. Impairment of cell mediated lympholysis associated with graft-vs-host disease and the effect of interleukin 2. J Immunol 130: 712

    PubMed  Google Scholar 

  88. Mutter W, Reddehase MJ, Busch FW, Buhring HJ, Koszinowski UH (1988) Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host. J Exp Med 167: 1645

    PubMed  Google Scholar 

  89. Neiderwieser D, Gastl G, Rumpold H, Marth C, Kraft D, Huber C (1987) Rapid reappearance of large granular lymphocytes (LGL) with concomitant reconstitution of natural killer (NK) activity after human bone marrow transplantation (BMT). Br J Haematol 65: 301

    PubMed  Google Scholar 

  90. Newhouse M, Sanchis J, Bienenstock J (1976) Lung defense mechanisms. N Engl J Med 295: 990

    PubMed  Google Scholar 

  91. Noel DR, Witherspoon RP, Storb A, Atkinson K, Doney K, Mickelson EM, Ochs HD, Warren RP, Weiden PL, Thomas ED (1978) Does graft-versus-host disease influence the tempo of immunologic recovery after allogeneic human marrow transplantation? An observation on 56 long term survivors. Blood 51: 1087

    PubMed  Google Scholar 

  92. Ohsaka A, Kitagawa S, Sakamoto S, Miura Y, Takanashi N, Takaku F, Saito M (1989) In vivo activation of human neutrophil functions by administration of human granulocyte colony stimulating factor in patients with malignant lymphoma. Blood 74: 743

    PubMed  Google Scholar 

  93. O'Reilly RJ, Brochstein J, Collins N, Kecver C, Kapoor N, Kirkpatrick D, Kernan N, Dupont B, Burns J, Reisner Y (1986) Evaluation of HLA-haplotype disparate parental marrow grafts depleted of T-lymphocytes by differential agglutination with a soybean lectin and E-rosette depletion for the treatment of severe combined immunodeficiency. Vox Sang 51: 81

    Google Scholar 

  94. Parisch JD, Maki DG (1986) Infectious complications in adults with bone marrow transplantation and T-cell depletion of donor marrow. Ann Intern Med 104: 619

    PubMed  Google Scholar 

  95. Parkman R (1991) The biology of bone marrow transplantation for severe combined immune deficiency. Adv Immunol 49: 381

    PubMed  Google Scholar 

  96. Parreira A, Smith J, Hows JM, Smithers SS, Apperley J, Rombos Y, Goldman JM, Gordan-Smith EC, Catovsky D (1987) Immunological reconstitution after bone marrow transplant with campath-1 treated bone marrow. Clin Exp Immunol 67: 142

    PubMed  Google Scholar 

  97. Paulin T, Ringden O, Lonnqvist B (1985) Faster Immunological recovery after bone marrow transplantation in patients without cytomegalovirus infection. Transplantation 39: 377

    PubMed  Google Scholar 

  98. Pedrazzini A, Freeman AS, Anderson J, Heflin L, Anderson K, Takavorian T, Canellos GP, Whitman J, Coral F, Ritz J, Nadler LM (1989) Anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation for B-cell non-Hodgkin's lymphoma: phenotypic reconstitution and B-cell function. Blood 74: 2203

    PubMed  Google Scholar 

  99. Peters WP (1991) The myeloid colony-stimulating factors: introduction and overview. Semin Hematol 28: 1

    Google Scholar 

  100. Rechumer H, Leinisch E, Bender-Gotze C, Ziegler-Heitbrock HW (1991) Recovery of monocytes after bone marrow transplantation-rapid reappearance of tumor necrosis factor alpha and interleukin 6 production. Transplantation 52: 698

    PubMed  Google Scholar 

  101. Reddehase MJ, Weiland F, Munch K, Jonjik S, Luske A, Koszinowski UH (1985) Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. J Virol 55: 264

    PubMed  Google Scholar 

  102. Reddehase MJ, Mutter W, Munch K, Buhring H-J, Koszinowski UH (1987) CD8-positive T-lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J Virol 61: 3102

    PubMed  Google Scholar 

  103. Reichert U, Saint LD, Schaeffer H (1982) Skin surface chemistry and microbial infection. Semin Dermatol 1: 91

    Google Scholar 

  104. Reusser P, Riddell SR, Meyers JD, Greenberg PD (1991) Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 78: 1373

    PubMed  Google Scholar 

  105. Rinaldo CR, Carney WP, Richter BS, Black PH, Hirsch MS (1980) Mechanism of immunosuppression in cytomegalovirus mononucleosis. J Infect Dis 141: 488

    PubMed  Google Scholar 

  106. Sanders ME, Makgoba MW, Shaw S (1988) Human naive and memory T-cells: reinterpretation of helper-inducer and suppressorinducer subsets. Immunol Today 9: 195

    PubMed  Google Scholar 

  107. Santos GW (1983) History of bone marrow transplantation. Clin Hematol 12: 611

    Google Scholar 

  108. Saxon A, Mitsuyasu R, Stevens R, Champlin RE, Kimata H, Gale RP (1986) Designed transfer of specific immune responses with bone marrow transplantation. J Clin Invest 78: 959

    PubMed  Google Scholar 

  109. Schroff RW, Gale RP, Fahey JL (1982) Regeneration of T-cell subpopulation after bone marrow transplantation: cytomegalovirus infection and lymphoid subset imbalance. J Immunol 129: 1926

    PubMed  Google Scholar 

  110. Schubert MM, Sullivan KM, Izutsu KT, Truelove EL (1983) Oral complication of bone marrow transplantation. In: Peterson DE, Sonis ST (eds) Oral complications of cancer chemotherapy. Nijhoff, The Hague, p. 93

    Google Scholar 

  111. Sheridan JF, Tutschka PJ, Sedmack DD, Copelan EA (1990) IgG subclass deficiency and pneumococcal infection after allogeneic BMT. Blood 75: 1583

    PubMed  Google Scholar 

  112. Sheridan WP, Morstyn G, Wolf M, Dodds A, Lusk J, Maher D, Layton JE, Green MD, Souza L, Fox RM (1989) Granulocyte colony-stimulating factor and neutrophil recovery after high dose chemotherapy and autologous bone marrow transplantation. Lancet II: 891

    Google Scholar 

  113. Shiobara S, Harada M, Mori T (1982) Difference in posttransplant recovery of immune reactivity between allogeneic and autologous bone marrow transplantation. Transplant Proc 14: 429

    PubMed  Google Scholar 

  114. Silber GM, Winkelstein JA, Moen RC, Horowitz SD, Trigg M, Hong R (1987) Reconstitution of T- and B-cell function after T-cell depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency. Clin Immunol Immunopathol 44: 317

    PubMed  Google Scholar 

  115. Small TN, Keever Ca, Weiner-Fedus S, Heller G, O'rilly RJ, Flomenberg N (1990) B-cell differentiation following autologous, conventional, or T-cell depleted bone marrow transplantation: a recapitulation of normal B-cell ontogeny. Blood 76: 1647

    PubMed  Google Scholar 

  116. Soiffer RJ, Bosserman L, Murray C, Cochran K, Daley J, Ritz J (1990) Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation. Blood 75: 2076

    PubMed  Google Scholar 

  117. Sosa R, Weiden PL, Storb R, Syrotuck J, Thomas ED (1980) Granulocyte function in human allogeneic bone marrow graft recipients. Exp Hematol 8: 1183

    PubMed  Google Scholar 

  118. Storek J, Saxon A (1992) Reconstitution of B-cell immunity following bone marrow transplantation. Bone Marrow Transplant 9: 395

    PubMed  Google Scholar 

  119. Strauss RG (1993) Therapeutic granulocyte transfusions in 1993. Blood 81: 1675

    PubMed  Google Scholar 

  120. Sullivan KM, Weiden PL, Storb R, Witherspoon RP, Fefer A, Fisher L, Buckner CD, Anasetti C, Appelbaum FR, Badger C, Beatty P, Besinger W, Berenson R, Bigelo C, Cheever MA, Clift R, Deeg HJ, Doney K, Greenberg P, Hansen JA, Hill R, Laughran T, Martin P, Neiman P, Peterson FB, Sanders J, Singer J, Stewart P, Thomas ED (1989) Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 73: 1720

    PubMed  Google Scholar 

  121. Sullivan KM, Kopecky KJ, Jocum J, Fisher L, Buckner CD, Meyers JD, Counts GW, Bowden RA, Petersen FB, Witherspoon RP, Budinger MD, Schwartz RS, Appelbaum FR, Clift RA, Hansen JA, Sanders JE, Thomas ED, Storb R (1990) Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. N Engl J Med 323: 705

    PubMed  Google Scholar 

  122. Sykes M, Bukhari Z, Sachs DH (1989) Graft-versus-leukemia effect using mixed allogeneic bone marrow transplantation. Bone Marrow Transplant 4: 465

    PubMed  Google Scholar 

  123. Sykes M, Romick ML, Sacks DL (1990) Interleukin-2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T-cells. Proc Natl Acad Sci USA 87: 5633

    PubMed  Google Scholar 

  124. Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone marrow transplantation. N Engl J Med 292: 895

    PubMed  Google Scholar 

  125. Thomas ED, Ramberg RE, Sale GE, Sparkes RS, Golde DW (1976) Direct evidence for a bone marrow origin of the alveolar macrophages in man. Science 192: 1016

    PubMed  Google Scholar 

  126. Truitt RL, Horowitz MM, Atasoylu AA, Drobyski WR, Johnson BD, LeFever AV (1992) Graft-versus-leukemia effect of allogeneic bone marrow transplantation: clinical and experimental aspects of late leukemia relapse. In: Stewart THM, Wheelock EF (eds) Cellular immune mechanisms and tumor dormancy. CRC, Boca Raton, Fla, p 111

    Google Scholar 

  127. Tsoi MS, Storb R, Dobbs S, Kopecky KJ, Santos E, Weiden PL, Thomas ED (1979) Nonspecific suppressor cells in patients with chronic graft versus host disease after marrow grafting. J Immunol 123: 1970

    PubMed  Google Scholar 

  128. Tsoi M-S, Dobbs S, Brkic S, Ramberg R, Thomas ED (1984) Cellular interaction in marrow-grafted patients. II. Normal monocyte antigen-presenting and defective T-cell proliferative functions early after grafting and during chronic graft-versus-host disease. Transplantation 37: 552

    PubMed  Google Scholar 

  129. Ueda M, Harada M, Shiobara S, Nakao S, Kondo K, Odaka K, Matsue K, Mori T, Hattori K-I (1984) T-lymphocyte reconstitution in long term survivors after allogeneic and autologous marrow transplantation. Transplantation 37: 552

    PubMed  Google Scholar 

  130. Velardi A, Terenzi A, Cucciaioni S, Millo R, Grossi CE, Grignani F, Martelli MF (1988) Imbalances within the peripheral blood T-helper (CD4+) and T-suppressor (CD8+) cell populations in the reconstitution phase after human bone marrow transplantation. Blood 71: 1196

    PubMed  Google Scholar 

  131. Verdonck LF, Gast GC de (1984) Is cytomegalovirus infection a major cause of T-cell alterations after (autologous) bone marrow transplantation? Lancet 1: 933

    Google Scholar 

  132. Verdonck LF, Linden JA van der, Bast BJEG, Meyling FHJG, Gast GC de (1987) Influence of cytomegalovirus infection on the recovery of humoral immunity after autologous bone marrow transplantation. Exp Hematol 15: 864

    PubMed  Google Scholar 

  133. Verlardi A, Speranza C, Terenzi A, Quinti I, Aversa F, Grossi CE, Grignani F, Martelli MF (1988) Acquisition of Ig isotype diversity after bone marrow transplantation in adults. A recapitulation of normal B-cell ontogeny. J Immunol 141: 815

    PubMed  Google Scholar 

  134. Walker RI, Owen RL (1990) Intestinal barriers to bacteria and their toxins. Annu Rev Med 41: 393

    PubMed  Google Scholar 

  135. Warren H, Atkinson K, Pembrey R, Biggs JC (1983) Human bone marrow allograft recipients: production of, and responsiveness to, interleukin 2. J Immunol 131: 1771

    PubMed  Google Scholar 

  136. Welte K, Ciobanu N, Moore MAS, Gulati S, O'Reilly RJ, Mertelsmann R (1984) Defective interleukin 2 production in patients after bone marrow transplantation and in vitro restoration of defective T lymphocyte proliferation by highly purified interleukin 2. Blood 64: 380

    PubMed  Google Scholar 

  137. Welte K, Keever CA, Levick J, Bonilla MA, Merluzzi VJ, Mertelsman R, Evans R, O'Reilly RJ (1987) Interleukin-2 production and response to interleukin-2 by peripheral blood mononuclear cells from patients after bone marrow transplantation. II. Patients receiving soybean lectin-seperated and T-cell-depleted bone marrow. Blood 70: 1595

    PubMed  Google Scholar 

  138. Winston DJ, Gale RP, Meyer DV, Young LS, UCLA Bone Marrow Transplant Group (1979) Infectious complications of human bone marrow transplantation. Medicine 58: 1

    PubMed  Google Scholar 

  139. Winston DJ, Territo MC, Miller MJ, Gale RP, Golde DW (1982) Alveolar macrophage dysfunction in bone marrow transplant recipients. Am J Med 73: 859

    PubMed  Google Scholar 

  140. Winston DJ, Ho WG, Champlin RE (1990) Cytomegalovirus infections after allogeneic bone marrow transplantation. Rev Infect Dis 12: 776

    Google Scholar 

  141. Witherspoon RP, Storb R, Ochs HD, Flournoy N, Kopecky KJ, Sullivan KM, Deeg HJ, Sosa R, Noel DR, Atkinson K, Thomas ED (1981) Recovery of antibody production in human allogeneic marrow graft recipients: influence of time post transplantation, the presence or absence of chronic graft versus host disease and antithymocyte globulin treatment. Blood 58: 360

    PubMed  Google Scholar 

  142. Witherspoon RP, Kopecky K, Storb R, Flournoy N, Sullivan KM, Sosa R, Deeg HJ, Ochs HD, Cheever MA, Fefer A, Thomas ED (1982) Immunological recovery in 48 patients following syngeneic marrow transplantation for hematological malignancy. Transplantation 33: 143

    PubMed  Google Scholar 

  143. Witherspoon RP, Mathews D, Storb R, Atkinson K, Cheever M, Deeg HJ, Doney K, Kalbfleisch J, Noel D, Prentice R, Sullivan KM, Thomas ED (1984) Recovery of in vivo cellular immunity after human marrow grafting: influence of time postgrafting and acute graft-versus-host disease. Transplantation 37: 145

    PubMed  Google Scholar 

  144. Witherspoon RP, Lum LG, Storb R (1984) Immunologic reconstitution after human marrow grafting. Semin Hematol 21: 2

    PubMed  Google Scholar 

  145. Zander AR, Reuben JM, Johnston D, Vellekoop L, Dicke KA, Yau JC, Hersch EM (1985) Influence recovery following allogeneic bone marrow transplantation. Transplantation 40: 177

    PubMed  Google Scholar 

  146. Zimmerli W, Zarth A, Gratwohl A, Speck B (1991) Neutrophil function and pyogenic infections in bone marrow transplant recipients. Blood 77: 393

    PubMed  Google Scholar 

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  1. Bone Marrow Transplantation Program, Georgetown University, 20007, Washington DC, USA

    Udit N. Verma & Amitabha Mazumder

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Verma, U.N., Mazumder, A. Immune reconstitution following bone marrow transplantation. Cancer Immunol Immunother 37, 351–360 (1993). https://doi.org/10.1007/BF01526790

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