European Archives of Oto-Rhino-Laryngology

, Volume 254, Issue 2, pp 95–100 | Cite as

Neuronal responses to vestibular stimulation in the guinea pig hypothalamic paraventricular nucleus

  • F. Liu
  • A. Inokuchi
  • S. Komiyama
Original Paper


We investigated the effects of caloric stimulation on neuronal activity in the hypothalamic paraventricular nucleus (PVN) in anesthetized guinea pigs. Hot water stimulation of the contralateral labyrinth produced excitation in 29.4% of the PVN neurons tested, while cold water produced excitation in 22.2% of the neurons. Hot water resulted in inhibition of 22.4% of the neurons and cold water inhibition of 24.7% of the neurons. Intracranial vestibular nerve section greatly reduced responsiveness of the PVN neurons to caloric stimulation, indicating that the majority of the responses observed were vestibular in origin. The response pattern of the individual PVN neurons was similar following hot and cold water stimulation and after stimulation of the contralateral and ipsilateral labyrinths. These results suggest that the PVN neurons receive vestibular afferents bilaterally according to the intensity of vestibular stimulation, with the information received probably integrated in the hypothalamus to participate in vestibulo-autonomic reflexes.

Key words

Hypothalamic paraventricular nucleus Caloric stimulation Vestibulo-autonomic reflex Guinea pig 


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  1. 1.
    Akert K, Gernandt BE (1962) Neurophysiological study of vestibular and limbic influences upon vagal outflow. Electroencephalogr Clin Neurophysiol 14:904–914PubMedGoogle Scholar
  2. 2.
    Azzena GB, Melis F, Caria MA, Teatini GP, Bozzo G (1993) Vestibular projection to hypothalamic supraoptic and paraventricular nuclei. Arch Ital Biol 131:127–136PubMedGoogle Scholar
  3. 3.
    Büttner U, Buettner UW (1978) Parietal cortex (2v) neuronal activity in the alert monkey during natural vestibular and optokinetic stimulation. Brain Res 153:392–397PubMedGoogle Scholar
  4. 4.
    Büttner U, Hann V, Oswald HP (1977) Vestibular-related neuronal activity in the thalamus of the alert monkey during sinusoidal rotation in the dark. Exp Brain Res 30:435–444PubMedGoogle Scholar
  5. 5.
    Cobbold AF, Megirian D, Sherrey JH (1968) Vestibular evoked activity in autonomic motor outflows. Arch Ital Biol 106:113–123PubMedGoogle Scholar
  6. 6.
    Cowings PS, Suter S, Toscano WB, Kamiya J, Naifeh K (1986) General autonomic components of motion sickness. Psychophysiology 23:542–551PubMedGoogle Scholar
  7. 7.
    Furuya N, Kawano K, Shimazu H (1975) Functional organization of vestibulofastigial projection in the horizontal semicircular canal system in the cat. Exp Brain Res 24:75–87PubMedGoogle Scholar
  8. 8.
    Gardner EP, Fuchs AF (1974) Single-unit responses to natural vestibular stimuli and eye movement in deep cerebellar nuclei of the alert rhesus monkey. J Neurophysiol 38:627–649Google Scholar
  9. 9.
    Grüsser OJ, Pause M, Schreiter U (1982) Neuronal responses in the parieto-insular vestibular cortex of alert java monkeys (Maccaca fascicularis). In: Roucoux A, Crommelinck M (eds) Physiological and pathological aspects of eye movements. Junk, The Hague, pp 251–270Google Scholar
  10. 10.
    Horii A, Takeda N, Matsunaga T, Yamatodani A, Mochizuki T (1993) Effect of unilateral vestibular stimulation on histamine release from the hypothalamus of rats in vivo. J Neurophysiol 70:1822–1826PubMedGoogle Scholar
  11. 11.
    Inenaga K, Osaka T, Yamashita H (1987) Thermosensitivity of the paraventricular nucleus of the rat slice preparation. Brain Res 424:126–132PubMedGoogle Scholar
  12. 12.
    Inokuchi A, Liu F, Komiyama S (1994) Effects of vestibular stimulations on guinea pig posterior hypothalamic neuron activity. Otol Fukuoka 40:885–892Google Scholar
  13. 13.
    Ito J, Honjo I (1990) Central fiber connections of the vestibuloautonomic reflex arc in cats. Acta Otolaryngol (Stockh) 110:379–385Google Scholar
  14. 14.
    Kannan H, Hayashida Y, Yamashita H (1989) Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am J Physiol 256:R1325-R1330PubMedGoogle Scholar
  15. 15.
    Katafuchi T, Oomura Y, Aoyagi K (1987) Single neuron activity of rat hypothalamic paraventricular nucleus during body suspension. Neurosci Lett 78:301–306PubMedGoogle Scholar
  16. 16.
    Katafuchi T, Puthuraya KP, Yoshimatsu H, Oomura Y (1987) Responses of rat hypothalamic neuron activity to vestibular nuclei stimulation. Brain Res 400:62–69PubMedGoogle Scholar
  17. 17.
    Luiten PGM, Horst GJ ter, Karst H, Steffens AB (1985) The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res 329:374–378PubMedGoogle Scholar
  18. 18.
    Magnin M, Putkonen PTS (1978) A new vestibular thalamic area: electrophysiological study of the thalamic reticular nucleus and of the ventral lateral geniculate complex of the cat. Exp Brain Res 32:91–104PubMedGoogle Scholar
  19. 19.
    Mano T, Iwase S, Saito M, Koga K, Abe H, Inamura K, Matsukawa Y, Hashiba M (1988) Somatosensory vestibular sympathetic interactions in man under weightlessness stimulated by head-out water immersion. In: Hwang JC, Daunton NG, Wilson VJ (eds) Basic and applied aspects of vestibular function. Hong Kong University Press, Hong Kong, pp 193–203Google Scholar
  20. 20.
    Matsumura K, Nakayama T, Ishikawa Y (1983) Effects of preoptic thermal stimulation on electrical activities of neurosecretory cells in paraventricular and periventricular nuclei of the hypothalamus. Brain Res 289:330–333PubMedGoogle Scholar
  21. 21.
    Matsuoka I (1969) The responses of a single neuron of the vestibular nuclei to caloric stimulation of ipsilateral and contralateral labyrinth in the cat. Pract Otol (Kyoto) 62:91–100Google Scholar
  22. 22.
    Megirian D, Manning JW (1967) Input-output relations of the vestibular system. Arch Ital Biol 105:15–30PubMedGoogle Scholar
  23. 23.
    Money KE (1970) Motion sickness. Physiol Rev 50:1–39PubMedGoogle Scholar
  24. 24.
    Peterson BW, Filion M, Felpel LP, Abzug C (1975) Responses of medial reticular neurons to stimulation of the vestibular nerve. Exp Brain Res 22:335–350Google Scholar
  25. 25.
    Rössner W von (1965) Stereotaktischer Himatlas vom Meerschweinchen. Pallas, MunichGoogle Scholar
  26. 26.
    Saper CB, Loewy AD, Swanson LW, Cowan WM (1976) Direct hypothalamic autonomic connections. Brain Res 117:305–312PubMedGoogle Scholar
  27. 27.
    Shimazu H, Precht W (1965) Tonic and kinetic responses of cat's vestibular neurons to horizontal angular acceleration. J Neurophysiol 28:991–1013PubMedGoogle Scholar
  28. 28.
    Shimazu H, Precht W (1966) Inhibition of central vestibular neurons from the contralateral labyrinth and its mediating pathway. J Neurophysiol 29:467–492PubMedGoogle Scholar
  29. 29.
    Shinoda Y, Yoshida K (1974) Dynamic characteristics of responses to horizontal head angular acceleration in vestibular pathway in the cat. J Neurophysiol 37:653–673PubMedGoogle Scholar
  30. 30.
    Strack AM, Sawyer WB, Hughes JH, Platt KB, Loewy AD (1989) A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res 491:156–162PubMedGoogle Scholar
  31. 31.
    Tang PC, Gernandt BE (1969) Autonomic responses to vestibular stimulation. Exp Neurol 24:558–578PubMedGoogle Scholar
  32. 32.
    Yates BJ, Jakus J, Miller AD (1993) Vestibular effects on respiratory outflow in the decerebrate cat. Brain Res 629:209–217PubMedGoogle Scholar
  33. 33.
    Yoshimatsu H, Niijima A, Oomura Y, Yamabe K, Katafuchi T (1984) Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. Brain Res 303:147–152PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • F. Liu
    • 1
  • A. Inokuchi
    • 1
  • S. Komiyama
    • 1
  1. 1.Department of Otorhinolaryngology, Faculty of MedicineKyushu UniversityFukuokaJapan

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