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Local bacillus Calmette-Guérin therapy for bovine vulval papilloma and carcinoma

  • Original Articles
  • Immunotherapy, BCG, Bovine Vulval Papillomacarcinoma
  • Published:
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Abstract

Thirty cows from a pedigree Friesian dairy herd with bovine vulva papilloma and carcinoma were treated by intralesional injections of live bacillus Calmette-Guérin (BCG). This treatment induced total regression of all of six carcinomas. Whilst, after treatment, limited regression was also observed in advanced papillomas, BCG has little or no effect on the early stages of papillomas. This is the first study of BCG therapy in this type of cancer.

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References

  1. Brydon P (1960) The major causes for condemnation of meat in NSW. Aust Vet J 36: 113

    Google Scholar 

  2. Burdin ML (1964) Squamous-cell carcinoma of the vulva of cattle in Kenya. Res Vet Sci 5: 497

    Google Scholar 

  3. Catalona WJ, Hudson A, Gillen DP, Andriole GL, Ratliff (1987) Risks and benefits of repeated courses of intravesical bacillus Calmette Guérin therapy of superficial bladder cancer. J Urol 137: 220

    PubMed  Google Scholar 

  4. Hill FWG, Klein WR, Hoyer MH, Rutten VPMG, Kock N, Koten JW, Steerenberg PA, Ruitenberg EJ, Den Otter W (1994) Antitumor effect of locally injected low-doses of recombinant human interleukin-2 in bovine vulval papilloma and carcinoma Vet Immunol Immunopathol 41: 19–29

    PubMed  Google Scholar 

  5. Jarrett WFH (1985) The natural history of bovine papillomavirus infections. Adv Viral Oncol 5: 83–101

    Google Scholar 

  6. Jennings PA, Hoffman D, Wilson BE, (1979). Attempted immunotherapy and autotransplantation of bovine vulval squamous cell carcinoma. Aust Vet J 55: 604

    PubMed  Google Scholar 

  7. Klein WR, Ruitenberg EJ, De Jong WH, Kruizinga W, et al (1982) Immunotherapy by intralesional injection of BCG cell walls or live BCG in bovine ocular squamous cell carcinoma: a preliminary report. J Natl Cancer Inst 69: 1095

    PubMed  Google Scholar 

  8. Kleinschuster SJ, Rapp HJ, Leuker DC, Kainer RA (1977) Regression of bovine ocular squamous cell carcinoma by treatment with a mycobacterial vaccine. J Natl Cancer Inst 58: 1807

    PubMed  Google Scholar 

  9. Kleinschuster SJ, Rapp HJ, Green SB, Bier J, Van Kampen K (1981) Efficacy of intratumorally administered mycobacterial cell walls in the treatment of cattle with ocular carcinoma. J Natl Cancer Inst 67: 1165

    PubMed  Google Scholar 

  10. Rutten VPMG, Klein WR, De Jong WAC, Misdorp W, Den Otter W, Steerenberg PA, De Jong WH, Ruitenberg EJ (1989) Local IL-2 therapy in bovine ocular squamous cell carcinoma. A pilot study. Cancer Immunol Immunother 30: 165

    PubMed  Google Scholar 

  11. Rutten VPMG, Klein WR, De Jong WAC, Misdorp W, Steerenberg PA, De Jong WH, Den Otter W, Ruitenberg EJ (1991) Immunotherapy of bovine ocular squamous cell carcinoma (BOSCC) by repeated intralesional injections of live BCG or BCG cells walls. Cancer Immunol Immunother 34: 186

    PubMed  Google Scholar 

  12. Samuel JL (1989) Regression of bovine vulval squamous cell carcinoma after immunotherapy. Aust Vet J 66: 186

    PubMed  Google Scholar 

  13. Weltimuny SG de S (1974) Bovine vulval carcinoma in Ceylon. Zentralbl Veterinarmed [A] 21: 834

    Google Scholar 

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Authors and Affiliations

  1. Faculty of Veterinary Science, University of Zimbabwe, Mount Pleasant, P.O. Box MP 167, Harare, Zimbabwe

    F. W. G. Hill & M. H. Hoyer

  2. Department of Immunology, Faculty of Veterinary Medicine, Institute of Infectious Diseases and Immunology, Yalelaan 1, 3584 CL, Utrecht, The Netherlands

    V. P. M. G. Rutten & E. J. Ruitenberg

  3. Department of General and Large Animal Surgery, Faculty of Veterinary Medicine, P.O. Box 80.165, 3508 TD, Utrecht, The Netherlands

    W. R. Klein

  4. Department of Pathology, University Hospital Utrecht, P.O. Box. 85.500, 3508 GA, Utrecht, The Netherlands

    J. W. Koten & W. Den Otter

  5. National Institute of Public Health and Environmental Protection, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    P. A. Steerenberg & W. Den Otter

  6. Red Cross Blood Transfusion Service, Central Laboratory of the Netherlands, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    E. J. Ruitenberg

Authors
  1. F. W. G. Hill
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  2. V. P. M. G. Rutten
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  3. M. H. Hoyer
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  4. W. R. Klein
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  5. J. W. Koten
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  6. P. A. Steerenberg
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  7. E. J. Ruitenberg
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  8. W. Den Otter
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Hill, F.W.G., Rutten, V.P.M.G., Hoyer, M.H. et al. Local bacillus Calmette-Guérin therapy for bovine vulval papilloma and carcinoma. Cancer Immunol Immunother 39, 49–52 (1994). https://doi.org/10.1007/BF01517180

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  • DOI: https://doi.org/10.1007/BF01517180

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