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The effect of solvent dielectric constant on micellisation by lecithin

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Summary

Light-scattering, viscosity, and diffusion techniques have been used to study lecithin in solvents of dielectric constant varying from 2.3 to 42.8. Where two solvent components were present the molecular weights obtained from light-scattering were checked by diffusion-viscosity measurements (using a modifiedHilger-Rayleigh interferometer). As the dielectric constant is increased from that of benzene, the micelle size decreases, until at ε≏30, monomers are present; further increase of dielectric constant towards the value for water increases the micellar size. The small micelles on each side of the minimum in theε-micellar weight curve are likely to be monomolecular leaflets, while the larger micelles are bimolecular leaflets. Where water is present cmc.'s develop, and the micelles appear to be solvated. A few results for a synthetic dipalmitoyl lecithin are given. The relationship between cell membrane permeability and these results is discussed.

Zusammenfassung

Lichtstreuung, Viskosität und Diffusion wurden gemessen, um Lecithin in Lösungsmitteln im DK-Bereich von 2,3–42,8 zu untersuchen. Wenn zwei Lösungsmittelkomponenten verwendet wurden, wurden die aus der Lichtstreuung erhaltenen Molekulargewichte durch Diffusions-Viskositäts-Messungen nachgeprüft unter Verwendung eines modifiziertenHilger-Rayleigh-Interferrometers. Vergrößert sich die DK von der des Benzols an, so nimmt die Mycellengröße ab, bis bei ε ≈ 30 Monomere vorliegen. Weitere Vergrößerung der DK in Richtung auf den Wert für Wasser erhöht die Mycellengröße. Die kleinen Mycellen zu Seiten des Minimums der DK-Mycellgewicht-Kurve sind ähnlich wie molekulare Plättchen, während die größeren bimolekularen entsprechen. Bei Anwesenheit von Wasser treten kritische Mycellkonzentrationen auf und die Mycellen scheinen solvatisiert zu werden. Einige Resultate für synthetisches Dipalmitoyl-Lecithin sind ebenfalls angegeben. Die Beziehung zwischen der Zellmembran-Durchlässigkeit und diesen Ergebnissen wird diskutiert.

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  1. P. H. Elworthy & D. S. McIntosh

    Present address: School of Pharmacy, Royal College of Science and Technology, Glasgow, C. 1, UK

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    1. P. H. Elworthy
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    2. D. S. McIntosh
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    Elworthy, P.H., McIntosh, D.S. The effect of solvent dielectric constant on micellisation by lecithin. Kolloid-Z.u.Z.Polymere 195, 27–34 (1964). https://doi.org/10.1007/BF01500881

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