Summary
A new positive inotropic and vasodilator drug, AR-L 115 BS, a phenyl-imidazopyridine derivative was used for interventional ventriculography (VG) in 20 patients with coronary heart disease (CHD) and in 6 patients with dilated cardiomyopathy (CMP). Ejection fraction (EF) according to Simpsons rule was measured after biplane VG using 40–50 ml contrast medium (Urografin 76%). Ten min after IV application of 0.7 mg/kg body weight AR-L 115 BS a second VG was performed to evaluate possible improvement of wall motion. Pressures were recorded 1 and 4 min after each contrast injection and 1 and 4 min after injection of the drug. Results showed in the mean a significant increase of EF in the CHD group from 45% to 52% (P<0.01) and in the CMP group from 37% to 48% (P<0.05). Left ventricular enddiastolic pressure (LVEDP) decreased from 24±9.8 mm Hg to 15.4±9 mm Hg after 1 min and to 13.3±8.6 mm Hg after 4 min (P<0.001). Heart rate did not change significantly and systolic pressure decreased by 10% (P<0.01). Comparing LVEDP after the first to that taken after the second VG revealed a consistently lower pressure after the second contrast injection. In two patients a marked spontaneous angina could promptly be relieved by injection of AR-L 115 BS which brought about an accompanying strong decrease in filling pressure. It is concluded that AR-L 115 BS is a positive inotropic agent with a marked vasodilator effect leading to an improvement of ventricular function in patients with CMP as well as with CHD, Propagation of angina was not observed, probably due to the decrease of myocardial oxygen demand, arising from the agent's vasodilator effect, more than compensating for a possible increase from the inotropic effect.
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Stauch, M., Sigel, H., Scibold, H. et al. The effect of AR-L 115 BS on left ventricular function in patients with coronary heart disease and dilated cardiomyopathy. Klin Wochenschr 61, 759–764 (1983). https://doi.org/10.1007/BF01497403
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DOI: https://doi.org/10.1007/BF01497403