Summary
A panel of monoclonal antibodies that identify various antigens present on T and B cells was used to characterize circulating blood lymphocyte subsets in multiple myeloma [(MM) - 13 patients] and benign monoclonal gammopathy [(BMG) - 5 patients]. In MM and BMG an increase in B cell proportions (BA 1 positive cells) was observed, whereas T cells (Lyt 3 positive cells) were reduced compared to normal controls. However, with respect to the T cell subset distribution, a marked diversity between MM and BMG was noted. This may help to differentiate BMG from MM. In MM a relative decrease in inducer/helper T cells (OKT 4 positive cells) and increase in suppressor/cytotoxic T cells (OKT 8 positive cells) as well as in NK/K T cells (Leu 7 positive cells) was observed. On the other hand, in BMG the relative T cell subset distribution was comparable to those seen in normal subjects.
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Supported in parts by the Deutsche Forschungsgemeinschaft (Ru 215/2)
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Herrmann, F., Lochner, A., Jauer, B. et al. Lymphocyte subsets in the peripheral blood of patients with multiple myeloma and benign monoclonal gammopathy. Klin Wochenschr 61, 819–821 (1983). https://doi.org/10.1007/BF01496728
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DOI: https://doi.org/10.1007/BF01496728