Summary
The usefulness of T antigen in the diagnosis of lung cancer (LCA), including early, was assessed by determining the in vitro delayed type hypersensitivity response to T(DTHR-T), and by measuring with a solid phase immunofluorescent assay the serum anti-T IgM response. Sensitivity of DTHR-T was 89% for 73 patients with LCA including 8/9 with Stage T1N0M0 disease, overall specificity was 95% for 212 healthy persons and those with non-CA disease. The humoral immune assay detected 31/35 (89%) LCA patients including 4/5 Stage T1N0M0 patients. Overall specificity was >90% among 116 persons without CA.
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References
Anglin JH Jr, Lerner MP, Nordquist RE (1977) Blood group-like activity released by human mammary carcinoma cells in culture. Nature 269:254–255
Bray J, Maclean GD, Dusel FJ, McPherson TA (1982) Decreased levels of circulating lytic anti-T in the serum of patients with metastatic gastrointestinal cancer: a correlation with disease burden. Clin Exp Immunol 47:176–182
Burnet FM, Anderson SG (1947) The “T” antigen of guinea-pig and human red cells. Austral J Exp Biol Med Sci 25:213–217
Friedenreich V (1930) The Thomsen hemagglutination phenomenon. Levin & Munksgaard, Copenhagen
Goodale RL, Springer GF, Shearen JG, Desai PR, Tegtmeyer H (1983) Delayed-type cutaneous hypersensitivity to Thomsen-Friedenreich (T) antigen in patients with pancreatic cancer. J Surg Res (in press)
Howard DR, Taylor CR (1980) An antitumor antibody in normal human serum: Reaction of anti-T with breast carcinoma cells. Oncology 37:142–148
Springer GF, Cheingsong-Popov R, Schirrmacher V, Desai PR, Tegtmeyer H (1983) Proposed molecular basis of murine tumor cell — hepatocyte interaction. J Biol Chem 258:5702–5708
Springer GF, Desai PR (1982) Detection of lung- and breast carcinoma by quantitating serum anti-T IgM levels with a sensitive solid-phase immunoassay. Naturwissenschaften 69:346–348
Springer GF, Desai PR, Banatwala I (1975) Blood group MN antigens and precursors in normal and malignant human breast glandular tissue. J Natl Cancer Inst 54:335–339
Springer GF, Desai PR, Murthy MS, Tegtmayer H, Scanlon EF (1979) Human carcinoma-associated precursor antigens of the blood group MN system and the host's immune responses to them. Prog Allergy 26:42–96
Springer GF, Desai PR, Scanlon EF (1976) Blood group MN precursors as human breast carcinoma-associated antigens and “naturally” occurring human cytotoxins against them. Cancer 37:169–176
Springer GF, Murthy MS, Desai PR, Scanlon EF (1980) Breast cancer patients' cell-mediated immune response to Thomsen-Friedenreich (T) antigen. Cancer 45:2949–2954
Summers JL, Coon JS, Ward RM, Falor WH, Miller AW III, Weinstein RS (1983) Prognosis in carcinoma of the urinary bladder based upon tissue blood group ABH and Thomsen-Friedenreich antigen status and karyotype of the initial tumor. Cancer Res 43:934–939
Vos GH, Brain P (1981) Heterophile antibodies, immunoglobulin levels, and the evaluation of anti-T activity in cancer patients and controls. South Afr Med J 60:133–136
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Supported by U.S. Public Health Service Grant CA 19083
Fellow, American College of Chest Surgeons
Julia S. Michels Investigator in Surgical Oncology
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Fry, W.A., Springer, G.F. & Desai, P.R. Lung cancer patients' autoimmune responses to thomsen-friedenreich (T) antigen: Diagnostic utility. Klin Wochenschr 61, 817–818 (1983). https://doi.org/10.1007/BF01496727
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DOI: https://doi.org/10.1007/BF01496727