Summary
We report two cases of malignant pleural and pericardial effusion respectively secondary to bronchogenic carcinomas. In both effusions, a significant elevation of the Salivary-type-amylase fraction was found, while the corresponding values were normal in serum and urine. Electronmicroscopy of the malignant tumor cells from the pleural effusion showed typical electron-dense granules, suggesting zymogen granules. It is concluded that the high amylase content of the effusions was due to secretion of S-type-isoamylase by the tumor cells.
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References
Ammann RW, Berk JE, Fridhandler L, Ueda M, Wegmann W (1973) Hyperamylasemia with carcinoma of the lung. Ann Intern Med 78:521–525
Berk JE, Shimamura J, Fridhandler L (1978) Amylase changes in disorders of the lung. Gastroenterology 74:1313–1317
Colette B, Dratch M, Sorger K (1978) Amylase elevation attributable to an ovarian neoplasm. Gastroenterology 74:907–909
Cramer SF, Bruns DE (1979) Amylase-producing ovarian neoplasm with Pseudo-Meigs'Syndrome and elevated pleural fluid amylase. Cancer 44:1715–1721
Ende N (1960) Studies of amylase activity in pleural effusions and ascites. Cancer 13:283–287
Flege JB (1960) Ruptured tubal pregnancy with elevated serum amylase levels. Arch Surg 92:397–398
Hanafy HM, Gursel EO, Veenema RJ (1973) Increased serum amylase levels in prostatic diseases. Urology 1:372–373
Hankins JR, McLaughlin JS (1977) Pericarditis with effusion complicating esophageal perforation. J Thorac Cardiovasc Surg 73:225–230
Jam I, Shoham M, Wolf R, Mishkin S (1978) Elevated serum amylase activity in the absence of clinical pancreatic or salivary gland disease. Am J Gastroenterol 70:480–488
Lühr K (1951) Die Erhöhung des glykolytischen Ferments Diastase im Serum bei Bronchialkarzinom als Frühsymptom. MMW 48:2407
O'Donell MD, FitzGerald O, McGeeney KF (1977) Differential serum amylase determination by use of an inhibitor and design of an routine procedure. Clin Chem 23:560–566
Polowe D (1943) Blood amylase. Am J Clin Pathol 13:288–301
Salt WB, Schenker S (1976) Amylase-its clinical significance: A review of the literature. Medicine 55:269–289
Sawyers JL, Lane CE, Foster JH, Rollin AD (1975) Esophageal perforation. Ann Thoracic Surg 19:233–238
Susumu I (1977) The pancreas. In: Histology. McGraw-Hill Book Company, 4th edn, p 747
Ueda M, Kobayashi M, Taketa K, Sato J (1977) Ectopic production of a salyvary type amylase by adenocarcinoma cells: Demonstration by a culture technique. Clin Chim Acta 80:105–111
Weiss MJ, Edmonson HA, Wertmann M (1951) Elevated serum amylase associated with bronchogenic carcinoma. Am J Clin Pathol 21:1057–1061
Yokoyama M, Natsuizaka T, Ishii Y, Ohshima S, Kasagi A, Tateno S (1977) Amylase-producing lung cancer. Cancer 40:766–722
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Satz, N., Münch, R., Kuhlmann, U. et al. High amylase content of neoplastic pleural and pericardial effusion probably secondary to amylase producing tumor cells: Report of 2 cases. Klin Wochenschr 61, 91–94 (1983). https://doi.org/10.1007/BF01496660
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DOI: https://doi.org/10.1007/BF01496660