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Significance of Australia antigen in patients after kidney transplantation

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Summary

In patients under immunosuppressive therapy after kidney transplantation, the presence of Australia antigen frequently correlated with elevated serum transaminases. Therefore, parenchymal liver damage in such patients may be caused by subclinical viral hepatitis taking a mild but prolonged course.

Zusammenfassung

Bei 13 Patienten wurde Australia Antigen vor und nach Nierentransplantation im Krankheitsverlauf verfolgt. 6 Patienten waren vor und nach der Transplantation Antigenträger, einer entwickelte eine Antigenämie nach der Transplantation, 2 Patienten hatten Antikörper gegen Australia Antigen. Bei 4 Patienten wurden weder Au/SH-Antigen noch Antikörper gegen Australia Antigen gefunden. Bei 5 der 7 Australia Antigen-positiven Patienten und einem Patienten mit Antikörper, nicht dagegen bei 4 Australia Antigennegativen Patienten, wurden unter immunsuppressiver Therapie erhöhte Transaminaswerte im Serum festgestellt. Als Ursache der Leberparenchymschädigung bei diesen Patienten kann daher eine subklinisch aber protrahiert verlaufende akute Virushepatitis angenommen werden.

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Authors and Affiliations

  1. Department Innere Medizin, Department Chirurgie und Department für Pathologie der Medizinischen Hochschule Hannover, Germany

    R. Müller, K. Wonigeit, J. Bahlmann, F. W. Schmidt, R. Pichlmayr, H. Ostertag & H. Deicher

Authors
  1. R. Müller
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  2. K. Wonigeit
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  3. J. Bahlmann
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  4. F. W. Schmidt
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  5. R. Pichlmayr
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  6. H. Ostertag
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  7. H. Deicher
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Additional information

A preliminary report was read at the Vth International Congress of Infectious Diseases, Vienna, 31. 8.–5. 9. 1970.

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Müller, R., Wonigeit, K., Bahlmann, J. et al. Significance of Australia antigen in patients after kidney transplantation. Klin Wochenschr 49, 768–769 (1971). https://doi.org/10.1007/BF01495501

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  • DOI: https://doi.org/10.1007/BF01495501

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