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Reversible Thrombopenie bei klinischer Anwendung von Anti-lymphocytenserum

Reversible thrombopenia in the clinical use of anti-lymphocyte serum

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Summary

Some batches of antilymphocytic globulin prepared from tonsil material and peripheral blood lymphocytes were shown to cause thrombocytopenia. The results of thein vitro tests are described (PAT, TEG, platelet agglutination). The kinetics of platelet sequestration were evaluated by means of Cr51 labelling. Platets were found to be sequestrated in the spleen and/or liver, respectively.

Zusammenfassung

Einige Chargen von Antilymphocytenserum (aus Tonsillen und Blutlymphocyten) zeigten sowohl in vitro (PAT-Test, TEG, Thrombocytenagglutinationstest), als auch bei klinischer Anwendung eine ausgeprägte thrombopenische Nebenwirkung. Mittels Cr51 markierter Thrombocyten wurde die Sequestrationskinetik der Thrombocyten nach ALS-Medikation untersucht. Sequestrationsort waren Milz und/oder Leber.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Heidelberg, Germany

    K. Andrassy, E. Ritz, P. Drings & B. Kommerell

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  1. K. Andrassy
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  2. E. Ritz
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  3. P. Drings
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  4. B. Kommerell
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Andrassy, K., Ritz, E., Drings, P. et al. Reversible Thrombopenie bei klinischer Anwendung von Anti-lymphocytenserum. Klin Wochenschr 49, 47–48 (1971). https://doi.org/10.1007/BF01494066

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  • DOI: https://doi.org/10.1007/BF01494066

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