Orientierende Untersuchungen über die Aktivierung Fremdstoffe abbauender Enzyme durch fortgesetzte Psychopharmakotherapie

Zusammenfassung

Es werden die Ergebnisse erster orientierender Untersuchungen über die Aktivität Fremdstoffe abbauender Enzyme — gemessen an der Umsatzrate von Novalgin zu Aminoantipyrin — mitgeteilt, die durch fortgesetzte Therapie mit Psychopharmaka um im Mittel etwa 100% vermehrt wird. Einige Ausnahmen von der Regel werden kurz erörtert.

Summary

The results of preliminary investigations about the activity of enzymes metabolizing drugs — especially psychopharmacological active drugs — were reported. This activity was estimated by measuring the rate of excretion of 4-Aminoantipyrin in the urine within 6 hours after intravenous injection of 1 g Novalgin®. The normal value was 53.3 ± 7.0 mg (mean ± standard deviation) for both male and female. After therapeutic doses of several psychopharmacological active drugs (tranquillizer as well as neuroleptics, thymoleptics or thymerethics respectively) administrated to patients with several nervous and mental diseases for one week or longer the excretion values increased to 107.7±34.5 mg for male patients and to 93.2±17.2 mg for female ones (with regard to sex difference:t=2.193;p<0.05). The difference of the excretion rates of 4-Aminoantipyrin before and after therapy was highly significant (p<0.001). However there were some patients with excretion values within normal range. The possible causes of this finding was discussed.