Zusammenfassung
Sieben gesunde Probanden erhielten 20 mg Furosemid i.v. vor und nach viertägiger Einnahme von 1 g Acetylsalicylsäure p.o. täglich. Die furosemid-induzierte Abnahme der Uratausscheidung wurde hierdurch aufgehoben, die natriuretische Wirkung dagegen blieb unbeeinflußt. Es wird hieraus geschlossen, daß die beiden Medikamente über getrennte Mechanismen eine gegensinnige Wirkung auf die tubuläre Reabsorption der Urate ausüben.
Summary
Furosemid (20 mg) was administered intravenously to 7 healthy volunteers, before and after 4 days of oral administration of aspirin in uricosuric dosage (1 g daily). Aspirin prevented the decrease in urinary urate excretion induced by furosemide, without interfering with its natriuretic action. This finding is suggested to be the result of the opposite and independent effects of the two drugs on tubular reabsorption of urate.
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Mountokalakis, T., Rallis, D., Mayopoulou-Symvoulidou, D. et al. Effect of combined administration of furosemide and aspirin on urinary urate excretion in man. Klin Wochenschr 57, 1299–1301 (1979). https://doi.org/10.1007/BF01492986
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DOI: https://doi.org/10.1007/BF01492986