Skip to main content
SpringerLink
Log in

Plasma catecholamines in exercise induced bronchoconstriction

Plasmakatecholamine bei belastungsinduzierter Bronchokonstriktion

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Zusammenfassung

Bei 8 Patienten mit asymptomatischem, exogen allergischem Asthma bronchiale wurden die Plasma-Nor-Adrenalin(NA)- und die Adrenalin-(A)-Spiegel in Ruhe und sofort nach Belastung bestimmt. Die Patienten hatten in Ruhe einen normalen Bronchialwiderstand und entwickelten unter Belastung eine deutliche Bronchokonstriktion (BIB), die durch eine vorangehende Alpha-Rezeptorenblockade mit Phentolamin verhindert werden konnte. Bei 7 Kontrollpersonen wurden die NA- und A-Spiegel auch nach Beta-Rezeptorenblockade mit Propranolol gemessen.

Die folgenden Ergebnisse wurden erzielt:

  1. 1.

    Die NA-Spiegel zeigten in Ruhe keine signifikanten Unterschiede zwischen den Gruppen. Nach Belastung wurde bei allen Gruppen ein Anstieg des NA beobachtet, der jedoch bei den Patienten auch nach Phentolamin und bei den Normalpersonen nach Propranolol signifikant höher ausfiel als bei der Kontrollgruppe im Leerversuch.

  2. 2.

    Die A-Spiegel zeigten in Ruhe und nach Belastung keine signifikanten Gruppenunterschiede. Die Belastung führte zu keinem signifikanten A-Anstieg, außer bei der Normalgruppe nach Propranolol.

  3. 3.

    Zwischen den NA-Spiegeln nach Belastung und dem belastungsinduzierten Anstieg des Bronchialwiderstandes bestand keine signifikante Korrelation.

Es wird angenommen, daß 1. bei Asthmatikern unter Belastung die Sympathikusaktivität gesteigert ist und 2. die Provokation der BIB durch die unter Belastung gesteigerten NA-Spiegel unwahrscheinlich ist.

Summary

Plasma nor-epinephrine (NE) and epinephrine (E) levels at rest and immediately after exercise were estimated in 8 patients with asymptomatic extrinsic allergic bronchial asthma. The patients had a normal airway resistance at rest and developed a marked bronchoconstriction (EIB) during exercise, which could be prevented by previous alpha-adrenergic blockade with phentolamine. In 7 control persons NE and E levels were measured also after beta-adrenergic blockade with propranolol.

The following results were obtained:

  1. 1.

    At rest NE levels showed no significant differences between the groups. After exercise an increase of NE was observed in all groups, but in patients, even after phentolamine, and in normals after propranolol the increase was significantly higher than in the normal group within the control test.

  2. 2.

    No significant differences between the groups were found in E levels at rest and after exercise. Exercise caused no significant increase of E levels, except in the normals after propranolol application.

  3. 3.

    No significant correlation existed between NE levels and the increase of airway resistance after exercise.

It is concluded that during exercise in asthmatics the sympathetic activity is enhanced, but the provocation of an EIB does not seem to be mediated by enhanced plasma NE levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Alston, W.C., Patel, K.R., Kerr, J.W.: Response of leukocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic bronchial asthma. Brit. Med. J.1, 90 (1974)

    PubMed  Google Scholar 

  • Beil, M., DeKock, M.A.: Role of alpha-adrenergic receptors in exercise-induced bronchoconstriction. Unpublished data.

  • Brecht, H.M., Banthien, F., Schoeppe, W.: Decrease in plasma noradrenaline levels following long-term treatment with pindolol in patients with essential hypertension. Klin. Wschr.54, 1095 (1976)

    PubMed  Google Scholar 

  • Bianco, S., Griffin, J.P., Kamburoff, P.L., Prime, F.J.: Prevention of exercise induced asthma by Indoramin. Brit. Med. J.4, 18 (1974)

    PubMed  Google Scholar 

  • Christensen, N.J., Brandsborg, O.: The relationship between plasma catecholamine concentration and pulse rate during exercise and standing. Europ. J. clin. Invest.3, 299 (1973)

    PubMed  Google Scholar 

  • DeKock, M.A.: Mechanism of bronchial obstruction in man. In: Bronchitis III. Proceedings of the third international symposium on bronchitis at Groningen 1969. Royal Van Gorcum, Assen. 1970, p. 300

  • Fleisch, J.H., Kent, K.M., Cooper, Th.: Drug receptors in smooth muscle. In: Asthma. Physiology, immunopharmacology and treatment. Academic Press, New York, p. 139, 1973

    Google Scholar 

  • Griffiths, J., Leung, F.Y., Grzybowski, S., Chan-Yeung, M.M.W.: Sequential estimations of plasma catecholamines in exercise-induced asthma. Chest62, 527 (1972)

    PubMed  Google Scholar 

  • Häggendahl, J., Hartley, L.H., Saltin, B.: Arterial norepinephrine concentration during exercise in relation to relative work levels. Scand. J. Clin. Lab. Invest.26, 336 (1970)

    Google Scholar 

  • Irving, M.H., Britton, B.I., Wood, W.G., Padgham, C., Carruthers, M.: Effects of beta-adrenergic blockade on plasma catecholamines in exercise. Nature248, 531 (1974)

    PubMed  Google Scholar 

  • Parker, C.W.: Adrenergic responsiveness in asthma. In: Asthma. Physiology, immunopharmacology and treatment. Acad. Press New York, p. 185 (1973)

    Google Scholar 

  • Patel, K.R., Kerr, J.W.: The airway-response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma. Clin. Allergy3, 439 (1973)

    PubMed  Google Scholar 

  • Planz, G., Wiethold, G., Appel, E., Böhmer, D., Palm, D., Grobecker, H.: Correlation between increased dopamine-beta-hydroxylase activity and catecholamine concentration in plasma: Determination of acute changes in sympathetic activity in man. Europ. J. clin. Pharmacol.8, 181 (1975)

    Article  Google Scholar 

  • Renzini, V., Brunori, C.A., Valori, C.: A sensitive and specific fluorometric method for the determination of noradrenaline and adrenaline in human plasma. Clin. Chim. Acta.30, 587 (1970)

    Article  PubMed  Google Scholar 

  • Simonssen, B.G., Svendmyr, N., Skoogh, B.E.: In vivo and in vitro studies on alpha receptors in human airways. Scand. J. Resp. Dis.53, 227 (1972)

    Google Scholar 

  • Szentivanyi, A.: The beta-adrenergic theory of the atopic abnormality in bronchial asthma. J. Allergy42, 203 (1968)

    Google Scholar 

  • Ulmer, W.T., Reif, E.: Die obstruktiven Erkrankungen der Atemwege. Dtsch. med. Wschr.90, 1803 (1965)

    PubMed  Google Scholar 

  • Yamaguchi, N., Champlain, J., Nadeau, R.: Correlation between the response of the heart to sympathetic stimulation and the release of endogenous catecholamines into the coronary sinus of the dog. Circulat. Res.36, 662 (1975)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Lungenfunktionsforschung Bochum in Verbindung mit der Westfälischen Wilhelms-Universität Münster i.W., Germany

    M. Beil, H. M. Brecht & B. Rasche

  2. Zentrum der Inneren Medizin, Abteilung Nephrologie, der Johann-Wolfgang-Goethe-Universität Frankfurt a.M., Germany

    M. Beil, H. M. Brecht & B. Rasche

  3. Medizinische Abteilung des Silikose-Forschungsinstitutes der Bergbau-Berufsgenossenschaft, Hunscheidtstr. 12, D-4630, Bochum, Federal Republic of Germany

    M. Beil

Authors
  1. M. Beil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. M. Brecht
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Rasche
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Beil, M., Brecht, H.M. & Rasche, B. Plasma catecholamines in exercise induced bronchoconstriction. Klin Wochenschr 55, 577–581 (1977). https://doi.org/10.1007/BF01490511

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01490511

Schlüsselwörter

Key words

Search

Navigation