Summary
86Rubidium influx and Na — K-cotransport have been investigated in erythrocytes of mild essential hypertensives and normotensives devoid of familial hypertension.
For measurement of cotransport Na-loaded/K-depleted erythrocytes were used while rubidium influx (with and without ouabain) was determined under physiological conditions. Both transport systems were linear in time, the interassay variances in a range of about 10%.
The patients with essential hypertension exhibited a decreased rubidium influx compared to the normotensive controls. Ouabain-sensitive fluxes were not significantly different between the two groups, whereas ouabain-resistent rubidium influx was diminished in the group of the patients. Na — K-cotransport was also found to be decreased in essential hypertension. There was no correlation between cotransport and Rb-influx.
The results indicate changes in cation fluxes in erythrocytes of essential hypertensives, the Na — K-cotransport being rather more altered than rubidium influx. It is speculated that hypertensive persons with reduced rubidium flux rates may represent a subpopulation of essential hypertension and that their high blood pressure may be additionally influenced by exogeneous factors e.g. enhanced sodium uptake.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Ambrosioni E, Costa FV, Montebugnoli F, Tartagni F, Magnani B (1981) Increased intralymphocytic sodium content in essential hypertension: an index of impaired Na+ cellular metabolism. Clin Sci 61:181–186
Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol 232:C 165-C 173
Canali M, Borghi L, Sani E, Curti A, Montanari A, Novarini A, Barghetti A (1981) Increased erythrocyte lithiumsodium countertransport in essential hypertension: its relationship to family history hypertension. Clin Sci 61:13–15
Canessa M, Adragna N, Solomon H, Connolly T, Tosteson DC (1980) Sodium-lithium countertransport is increased in red cells of patients with essential hypertension. N Engl Med J 302:772–776
Cusi D, Barlassina C, Ferrandi M, Palazzi P, Celega E, Bianchi G (1981) Relationship between altered Na — K-cotransport and Na — Li-countertransport in the erythrocytes of “essential” hypertensive patients. Clin Sci 61:33–36
Edmondson RPS, Thomas RD, Hilton PS, Patrick J, Jones NF (1975) Abnormal leucocyte composition and sodium transport in essential hypertension. Lancet II:1003–1005
Friedman SM, Friedman CL (1976) Cell permeability, sodium transport and hypertensive process in the rat. Circ Res 29:433–441
Garay R, Adragna N, Canessa M, Tosteson DC (1981) Outward Na — K-cotransport in human erythrocytes. J Membrane Biol 62:169–174
Garay R, Elghozi J, Dagher G, Meyer P (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. N Engl J Med 302:769–771
Jones AW (1973) Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats. Circ Res 33:563–571
Kawasaki T, Delea CS, Bartter FC, Smith H (1978) The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med 64:193–198
Losse H, Wehmeyer H, Wessels F (1960) Der Wasser-und Elektrolytgehalt von Erythrozyten bei arterieller Hypertonie. Klin Wochenschr 38:393–395
Mann JFE, Gless KH, Fiehn W, Ganten D, Ritz E (1981) Cation fluxes of red blood cells in experimental hypertension. 8th Int Congress of Nephrology, Athens, HK 014
Meyer P, Garay R, Nazaret C, Dagher G, Bellet M, Broyer M, Feingold J (1981) Inheritance of abnormal erythrocyte cation transport in essential hypertension. Br Med J 282:1114–1117
Overbeck HW, Pamnani MB, Akera T, Brady TM, Haddy FJ (1976) Depressed function of a Ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs. Circ Res [Suppl II] 38:48–52
Poston L, Sewell RB, Wilkinson SP, Richardson PJ, Williams R, Clarkson EM, MacGregor GA, De Wardener HE (1981) Evidence for a circulating sodium transport inhibitor in essential hypertension. Br Med J 282:847–849
Sarkadi B, Alifimoff JK, Gunn RB, Tosteson DC (1978) Kinetics and stoichiometry of Na-dependent Li transport in human red blood cells. J Gen Physiol 72:249–265
Swarts HGP, Bonting SL, De Pont JJHHM, Schuurmans Stekhoven FMAH, Thien TA, Van't Laar A (1981) Cation fluxes and (Na+K)-activated ATPase activity in erythrocytes of patients with essential hypertension. Clin Exp Hypertension 3:831–849
Wambach G, Helber A, Bönner G, Hummerich W (1979) Natrium-Kalium-Adenosintriphosphatase-Aktivität in Erythrozytenghosts von Patienten mit essentieller Hypertonie. Klin Wochenschr 57:169–172
Wessels F, Jung-Hülsing G, Losse H (1967) Untersuchungen zur Natriumpermeabilität der Erythrozyten bei Hypertonikern und Normotonikern mit familiärer Hochdruckbelastung. Z Kreislaufforsch 56:374–380
Woods JW, Falk R, Pittmann AW, Klemmer PJ, Watson BS, Namboodiri K (1982) Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents. N Engl J Med 306:593–595
Woods KL, Beevers DG, West M (1981) Familial abnormality of erythrocyte cation transport in essential hypertension. Br Med J 282:1186–1188
Author information
Authors and Affiliations
Additional information
Mit Unterstützung des Bundesministerium für Forschung und Technologie (MMT 27)
Rights and permissions
About this article
Cite this article
Gless, K.H., Roelcke, U., Fiehn, W. et al. Kationenfluxe am Erythrozyten bei Patienten mit essentieller Hypertonie. Klin Wochenschr 61, 517–521 (1983). https://doi.org/10.1007/BF01488719
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01488719