Zusammenfassung
Die spezifischen Determinanten derγ-Globulin-Gruppen Gm(a), Gm(b), Gm(x) und Gm(r) konnten gemeinsam auf der F-Komponente desγ ss-Globulins lokalisiert werden. Diese Befunde stehen in guter Übereinstimmung mit den formalgenetischen Kenntnissen über die Vererbung des Gm-Systems. Die Bedeutung dieser Ergebnisse für die Physiologie und Pathologie desγ-Globulin-Systems wurde ausführlich diskutiert.
Summary
The group-specific determinants of theγ-globulin groups Gm(a), Gm(b), Gm(x), and Gm(r) have been localized on the F component of normal human 7Sγ-globulins. These results are in good agreement with the available information about the inheritance of the Gm-system. The importance of the findings for the physiology and pathology of theγ-globulin system is discussed.
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Literatur
Grubb, R.: Agglutination of erythrocytes coated with “incomplete” anti-Rh by certain rheumatoid arthritic sera and some other sera. The existence of human serum groups. Acta path. microbiol. scand.39, 195 (1956).
Steinberg, A. G.: Progress in the study of genetically determined human globulin types (the Gm and Inv groups). Progr. Med. Genet.2, 1 (1962).
Fudenberg, H.: The hereditary human gamma globulin (Gm) groups: Interpretations and extensions. Progr. Allergy7, 1 (1963).
Deicher, H., G. G. Wendt, U. Theile u.G. Kirchberg: Familienuntersuchungen über die Gammaglobulingruppen Gm(a), Gm(b), Gm(x) und Gm(r). Acta genet. (Basel)13, 124 (1963).
Harboe, M., andJ. Lundevall: A new type in the Gm system. Acta path. microbiol. scand.45, 357 (1959).
Harboe, M., C. K. Osterland, andH. G. Kunkel: Geneticγ-globulin (Gm and Inv) characteristics of myeloma proteins and their localisation in the split products produces by papain. Ann. N. Y. Acad. Sci.101, 235 (1962).
Harboe, M., C. K. Osterland, andH. G. Kunkel: Localisation of two genetic factors to different areas ofγ-globulin molecules. Science136, 979 (1962).
Harboe, M., andC. K. Osterland: Genetically determined structures of immune-Globulins, in: Immunopathology, IIIrd International Symposium, herausgeg.von P. Grabar undP. A. Miescher. Basel u. Stuttgart: Benno Schwabe & Co. 1963.
Franklin, E. C., H. Fudenberg, M. Meltzer, andD. R. Stanworth: The structural basis for genetic variations of normal humanγ-globulins. Proc. nat. Acad. Sci. (Wash.)48, 914 (1962).
Deicher, H.: Lokalisation der erblichen Determinante Gm(a) auf einemγ-Globulin-Fragment. Klin. Wschr.40, 1008 (1962).
Edelman, G. M., J. F. Heremans, M.-Th. Heremans, andH. G. Kunkel: Immunological studies of humanγ-globulins. Relation of the precipitin lines of wholeγ-globulin to those of the fragments produces by papain. J. exp. Med.112, 203 (1960).
Fahey, J. L.: Heterogeneity ofγ-globulin. Adv. Immunol.2, 41 (1962).
Heremans, J.: Les globulines sériques du système gamma, leur nature et leur pathologie. Brüssel: Edit. Arscia S.A. 1960.
Franklin, E. C., andD. R. Stanworth: Antigenic relationships between immune globulins and certain related Paraproteins in man. J. exp. Med.114, 521 (1961).
Edelman, G. M., andB. Benacerraf: On structural and functional relations between antibodies and proteins of the gamma system. Proc. nat. Acad. Sci. (Wash.)48, 1035 (1962).
Deicher, H.: Klin. Wschr.42, 313 (1964).
Kunkel, H. G.: Zone electrophoresis. In: Methods of Biochemical Analysis, vol. 1, p. 141. New York: Interscience 1954.
Müller-Eberhard, H. J., andH. G. Kunkel: The Carbohydrate ofγ-globulin and myeloma proteins. J. exp. Med.104, 253 (1956).
Franklin, E. C.: Structural units of human 7 S gamma globulin. J. clin. Invest.39, 1933 (1960).
Scheidegger, J. J., Une micro-méthode de l'immuno-electrophorése. Int. Arch. Allergy7, 103 (1955).
Olins, D. E., andG. M. Edelman: The antigenic structure of the polypeptide chains of humanγ-globulin. J. exp. Med.116, 635 (1962).
Kunkel, H. G., E. C. Franklin, andH. J. Müller-Eberhard: Studies on the isolation and characterization of the “rheumatoid factors”. J. clin. Invest.38, 424 (1959).
Steinberg, A. G.: Studies on the Gm factors: Comparison of the agglutinators in serum from patients with rheumatoid arthritis and in serum from healthy donors. Arthr. and Rheum.5, 331 (1962).
Harboe, M.: Quantitative studies on the haemagglutination reaction for determination of the Gm types. Acta path. microbiol. scand.47, 199 (1959).
Ropartz, C., P. Y. Rousseau etL. Rivat: Essai d'interprétation quantitative de qualités des réactifs anti-Gm. Rev. Franc. Etudes Clin. et Biol.6, 591 (1961).
Ropartz, C., L. Rivat u.P. Y. Rousseau: Persönliche Mitteilung.
Steinberg, A. G., B. D. Giles, andR. Stauffer: A Gm-like factor present in negroes and rare or absent in whites: Its relation to Gma and Gmx. Amer. J. hum. Genet.12, 44 (1960).
Barandun, S., K. Stampfli, G. A. Spengler u.G. Riva: Die Klinik des Antikörpermangelsyndroms. Helv. med. Acta26, 163 (1953).
Rosen, F. S., S. V. Kevy, E. Merler, C. A. Janeway, andD. Gitlin: Recurrent bacterial infections and dysgammaglobulinemia: Deficiency of the 7 Sγ-globulins in the presence of elevated 19 Sγ-globulins. Pediatrics28, 182 (1961).
Fudenberg, H., J. F. Heremans, andE. C. Franklin: A hypothesis for the genetic control of synthesis of theγ-globulins. Ann. Inst. Pasteur104, 155 (1963).
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Mit Unterstützung der Deutschen Forschungsgemeinschaft und der Behringwerke AG, Marburg a. d. Lahn.
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Deicher, H. Lokalisation mehrerer Gm-Gruppen-Determinanten auf demselben γ-Globulin-Fragment. Klin Wochenschr 42, 370–374 (1964). https://doi.org/10.1007/BF01488631
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DOI: https://doi.org/10.1007/BF01488631