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Die Reaktion von Rheumafaktoren mit humanem und tierischem γ-Globulin

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Zusammenfassung

Die Reaktion von RF aus 51 PCP-Seren mitγ-Globulinen von sieben verschiedenen Species wurde mit zwei verschiedenen rheumaserologischen Tests untersucht. Es konnte gezeigt werden, daß RF mitγ-Globulinen vieler verschiedener Species in ähnlicher Weise reagieren. Durch Hämagglutinations-Hemmungsversuche konnte nachgewiesen werden, daß es sich hierbei um eine typische immunologische Kreuzreaktion handelt, wobei das homologe Antigen der RF in jedem Falle das humaneγ-Globulin ist. Da die Kreuzreaktion mit verwandten heterologen Antigenen eine typische Antikörper-Eigenschaft ist, stehen diese Untersuchungen in Übereinstimmung mit der Auffassung, daß Rheumafaktoren Antikörper gegen humanesγ-Globulin sind.

Summary

The reaction of the rheumatoid factors contained in the sera of 51 individual patients with definite rheumatoid arthritis, withγ-globulin of seven species has been investigated. Two different serological methods were employed. Most rheumatoid factors reacted similarly with the different species'γ-globulins. Using a hemagglutination inhibition technique it could be shown that humanγ-globulin behaved as the homologous antigen, whereas the reaction with the animalγ-globulins obviously represented an immunological crossreaction. These results provide further evidence in favour of the antibody nature of the rheumatoid factors.

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  1. Aus der Medizinischen Universitäts-Poliklinik Marburg a. d. Lahn, Germany

    H. Deicher

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Mit Unterstützung der Deutschen Forschungsgemeinschaft und der Behringwerke AG, Marburg a. d. Lahn.

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Deicher, H. Die Reaktion von Rheumafaktoren mit humanem und tierischem γ-Globulin. Klin Wochenschr 42, 367–370 (1964). https://doi.org/10.1007/BF01488630

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