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Regionale Chemotherapie maligner Tumoren

II. Hochdosierte Stickstofflostbehandlung mit temporärer Kompression der Bauchaorta und ihrer Kollateralen

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Zusammenfassung

Die temporäre Unterbrechung des Kreislaufs in der unteren Körperhälfte mit Hilfe eines pneumatischen Gürtels schützte das Knochenmark des Beckens weitgehend vor der Wirkung hoher Dosen von Stickstofflost oder Chloriminlost, wenn diese in eine Armvene injiziert wurden. Bei 16 von 40 Kranken mit anaplastischen Plattenepithelearcinomen des Nasopharynx wurde eine über Monate anhaltende Tumorregression mit entsprechender Besserung des Allgemeinbefindes erzielt. Nach spätestens 8 Monaten trat jedoch ein Rezidiv auf. Die tolerierte Dosis wurde nicht durch die Wirkung auf das Knochenmark, sondern durch Zeichen der Schädigung des Zentralnervensystems begrenzt.

Summary

Temporary mid — torso occlusion by means of a pneumatic tourniquet protected the pelvic bone marrow against the effects of high doses of nitrogen mustard and chlorimine mustard, injected into an arm vein. In 16 out of 40 patients with anaplastic carcinoma of the postnasal space regression of the tumor and corresponding improvement of the performance status, lasting for several months, were observed. Recurrence became evident latest after 8 months. The tolerated dose was limited not by bone marrow depression but by other toxic effects, presumably on the central nervous system.

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Authors and Affiliations

  1. Aus der Medizinischen Poliklinik der Universität Köln, Germany

    Herbert F. Oettgen, Peter Clifford, John L. Beecher & John H. Gillmore

  2. Der Medizinischen Klinik der Städtischen Krankenanstalt Köln-Merheim, Germany

    Herbert F. Oettgen, Peter Clifford, John L. Beecher & John H. Gillmore

  3. Dem Sloan Kettering Institute for Cancer Research, New York

    Herbert F. Oettgen, Peter Clifford, John L. Beecher & John H. Gillmore

  4. Dem King George VI. Hospital, Nairobi, Kenya

    Herbert F. Oettgen, Peter Clifford, John L. Beecher & John H. Gillmore

Authors
  1. Herbert F. Oettgen
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  2. Peter Clifford
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  3. John L. Beecher
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  4. John H. Gillmore
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Additional information

Die Untersuchungen wurden unterstützt durch die Alfred P. Sloan Foundation, die Charles F. Kettering Foundation, den Charles Merrill Trust und die American Cancer Society.

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Oettgen, H.F., Clifford, P., Beecher, J.L. et al. Regionale Chemotherapie maligner Tumoren. Klin Wochenschr 42, 218–224 (1964). https://doi.org/10.1007/BF01487946

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  • DOI: https://doi.org/10.1007/BF01487946

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