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ADH-Plasmaspiegel und -Verteilungsraum nach exogener Zufuhr von ADH am Menschen

Untersuchungen zum Problem der hepatischen ADH-Inaktivierung bei Gesunden und bei Lebercirrhose

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Summary

Using the European toad Bufo bufo for a biological assay the plasma level of ADH was determined in four healthy individuals and in four patients with cirrhosis of the liver after intravenous injection of 2,5–4 units of ADH. The gradient of decrease of the ADH plasma level was steep during the first 3–4 minutes following the injection, thereafter it was exponential. This shows that there is an initial diffusion of the exogenous ADH out of the blood into tissue fluid. The calculated volume of distribution was in the range of the extracellular volume. There was a more rapid and statistically significant elimination of exogenous ADH from the blood in patients with cirrhosis of the liver than in persons with intact liver function. Possible causes of these differences are discussed. A delayed inactivation of ADH by the liver and thus a prolonged duration of action of exogenous ADH in liver cirrhosis can be excluded.

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  1. Aus der. I. Medizinischen Universitätsklinik München, Germany

    G. Hör, H. Avenhaus & E. Buchborn

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  1. G. Hör
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  2. H. Avenhaus
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Mit Unterstützung der Deutschen Forschungsgemeinschaft. — FräuleinC. Henschel haben wir für ihre technische Assistenz zu danken.

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Hör, G., Avenhaus, H. & Buchborn, E. ADH-Plasmaspiegel und -Verteilungsraum nach exogener Zufuhr von ADH am Menschen. Klin Wochenschr 41, 366–371 (1963). https://doi.org/10.1007/BF01487864

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